Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Temilolu Idowu"'
Autor:
Partho Protim Adhikary, Temilolu Idowu, Zheng Tan, Christopher Hoang, Selina Shanta, Malti Dumbani, Leah Mappalakayil, Bhuwan Awasthi, Marcel Bermudez, January Weiner, Dieter Beule, Gerhard Wolber, Brent DG Page, Sarah Hedtrich
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 7, Pp 1630-1656 (2024)
Abstract Thymic stromal lymphopoietin (TSLP) is a key player in atopic diseases, which has sparked great interest in therapeutically targeting TSLP. Yet, no small-molecule TSLP inhibitors exist due to the challenges of disrupting the protein–protei
Externí odkaz:
https://doaj.org/article/6e1c32879ae240dfae3a2ec89df67bbc
Autor:
Ayodeji Oluwabunmi Oriola, Adetunji Joseph Aladesanmi, Thomas Oyebode Idowu, Florence O. Akinwumi, Efere Martins Obuotor, Temilolu Idowu, Adebola Omowunmi Oyedeji
Publikováno v:
Molecules, Vol 26, Iss 21, p 6528 (2021)
Globimetula braunii is a hemi-parasitic plant used in African ethnomedicine for the management of microbial infections, rheumatic pain and tumors amongst others. We report the isolation and characterization of eight compounds with their antioxidant a
Externí odkaz:
https://doaj.org/article/a63715ea4b5f478f88aaddb5b46576aa
Autor:
Makanjuola Ogunsina, Pranati Samadder, Temilolu Idowu, Mark Nachtigal, Frank Schweizer, Gilbert Arthur
Publikováno v:
Molecules, Vol 25, Iss 3, p 566 (2020)
A major impediment to successful cancer treatment is the inability of clinically available drugs to kill drug-resistant cancer cells. We recently identified metabolically stable l-glucosamine-based glycosylated antitumor ether lipids (GAELs) that wer
Externí odkaz:
https://doaj.org/article/d19affeed2994b37906d0652e9810e13
Autor:
Temilolu Idowu, Frank Schweizer
Publikováno v:
Antibiotics, Vol 6, Iss 4, p 26 (2017)
Fluoroquinolones are synthetic antibacterial agents that stabilize the ternary complex of prokaryotic topoisomerase II enzymes (gyrase and Topo IV), leading to extensive DNA fragmentation and bacteria death. Despite the similar structural folds withi
Externí odkaz:
https://doaj.org/article/0fa00d6d158a4166b629f1b1a28d1088
Autor:
Oreofe Okunnu, George G. Zhanel, Liting Bi, Frank Schweizer, Ayush Kumar, Marc Brizuela, Temilolu Idowu, Derek Ammeter, Yanelis Acebo Guerrero, Xuan Yang, Ronald Domalaon
Publikováno v:
European Journal of Medicinal Chemistry. 175:187-200
The inability to discover novel class of antibacterial agents, especially against Gram-negative bacteria (GNB), compel us to consider a broader non-conventional approach to treat infections caused by multidrug-resistant (MDR) bacteria. One such appro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67bec7562416947691a8e245cb0984d2
https://doi.org/10.1016/j.ejmech.2019.05.003
https://doi.org/10.1016/j.ejmech.2019.05.003
Publikováno v:
Antimicrob Agents Chemother
Ceftolozane-tazobactam is a potent β-lactam/β-lactamase inhibitor combination approved for the treatment of complicated intraabdominal and complicated urinary tract infections and, more recently, the treatment of hospital-acquired and ventilator-as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48e1a0a612c06d8078008bbb36510cb2
https://doi.org/10.1128/aac.02055-19
https://doi.org/10.1128/aac.02055-19
Autor:
Pranati Samadder, Makanjuola Ogunsina, Temilolu Idowu, Mark W. Nachtigal, Gilbert Arthur, Frank Schweizer
Publikováno v:
Molecules
Volume 25
Issue 3
Molecules, Vol 25, Iss 3, p 566 (2020)
Volume 25
Issue 3
Molecules, Vol 25, Iss 3, p 566 (2020)
A major impediment to successful cancer treatment is the inability of clinically available drugs to kill drug-resistant cancer cells. We recently identified metabolically stable L-glucosamine-based glycosylated antitumor ether lipids (GAELs) that wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f4d167923d2ec4832a99137c6bcfad9
Autor:
Adebola O. Oyedeji, Florence O. Akinwumi, Efere M. Obuotor, TO Idowu, A. J. Aladesanmi, Ayodeji Oluwabunmi Oriola, Temilolu Idowu
Publikováno v:
Molecules
Volume 26
Issue 21
Molecules, Vol 26, Iss 6528, p 6528 (2021)
Volume 26
Issue 21
Molecules, Vol 26, Iss 6528, p 6528 (2021)
Globimetula braunii is a hemi-parasitic plant used in African ethnomedicine for the management of microbial infections, rheumatic pain and tumors amongst others. We report the isolation and characterization of eight compounds with their antioxidant a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::148a29dda54a48c99b2b0cb480ed0eb1
https://doi.org/10.3390/molecules26216528
https://doi.org/10.3390/molecules26216528
Publikováno v:
Journal of medicinal chemistry. 62(20)
Low permeability across the outer membrane is a major reason why most antibiotics are ineffective against Gram-negative bacteria. Agents that permeabilize the outer membrane are typically toxic at their effective concentrations. Here, we report the d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71b6d02fd80d95ffdec702563685790d
https://pubmed.ncbi.nlm.nih.gov/31557020
https://pubmed.ncbi.nlm.nih.gov/31557020
Publikováno v:
The Journal of antibiotics. 72(11)
The β-lactams are the most widely used class of antibiotics due to their safety, effectiveness, and spectrum of activity. As a result of their ubiquitous usage, there has been a steady rise in β-lactam resistant Gram-negative bacteria, especially P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fbb1ccf38aad500faf4ef5423512d1c
https://pubmed.ncbi.nlm.nih.gov/31420586
https://pubmed.ncbi.nlm.nih.gov/31420586