Zobrazeno 1 - 10
of 171
pro vyhledávání: '"Telomeric-Repeat Binding Factor"'
Publikováno v:
Acta Biochimica et Biophysica Sinica, Vol 56, Pp 607-620 (2024)
Myocardial damage is a critical complication and a significant contributor to mortality in sepsis. MicroRNAs (miRNAs) have emerged as key players in sepsis pathogenesis. In this study, we explore the effect and mechanisms of miR-29b-1-5p on sepsis-in
Externí odkaz:
https://doaj.org/article/571140f486d04f64ba8a73188abfa089
Autor:
Matheus Fabiao de Lima, Monique Oliveira Freitas, Mohammad K. Hamedani, Aline Rangel-Pozzo, Xu-Dong Zhu, Sabine Mai
Publikováno v:
Biomedicines, Vol 10, Iss 9, p 2299 (2022)
Telomere maintenance is key during cancer development. Malignant cells can either use telomerase or an alternative lengthening of telomere (ALT) pathway to maintain their telomere length. In Hodgkin’s Lymphoma (HL), the presence of telomerase activ
Externí odkaz:
https://doaj.org/article/f1824ce6d4724785ad3b70cf0cd83d72
Autor:
Taj Mohammad, Shama Khan, Mohamed F. Alajmi, Insan Habib, Afzal Hussain, Tabish Rehman, Farah Anjum, Md. Imtaiyaz Hassan
Publikováno v:
Journal of Biomolecular Structure and Dynamics. 40:9053-9066
Telomeric repeat binding factor 1 (TRF1) is one of the major components of the shelterin complex. It directly binds to the telomere and controls its function by regulating the telomerase acting on it. Several variations are reported in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52b2b1809457d2a01676b56b57bdc707
https://doi.org/10.1080/07391102.2021.1922313
https://doi.org/10.1080/07391102.2021.1922313
Publikováno v:
Asia Pacific Journal of Molecular Biology and Biotechnology. :98-106
Acute lymphoblastic leukemia (ALL) is the most frequent cancer among children. Regardless of the advances in disease treatments, approximately 10-20 % of childhood ALL (cALL) have an incidence of relapse. Therefore, identification of additional progn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9dfee34e51a2355e538a350567d270b8
https://doi.org/10.35118/apjmbb.2021.029.2.10
https://doi.org/10.35118/apjmbb.2021.029.2.10
Publikováno v:
Biochemical and Biophysical Research Communications. 559:252-258
Telomeric repeat binding factor a (Terfa) derived from zebrafish is a homologous protein with human telomeric repeat binding factor 2 (TRF2). Terfa is known as a senescence-associated biomarker in various research through the zebrafish animal model.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9f9a18fd965d29828efdee9ea51fc7f
https://doi.org/10.1016/j.bbrc.2021.04.057
https://doi.org/10.1016/j.bbrc.2021.04.057
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 2, Pp 309-321 (2021)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
Cullin-RING ligases (CRLs) recognize and interact with substrates for ubiquitination and degradation, and can be targeted for disease treatment when the abnormal expression of substrates involves pathologic processes. Phosphorylation, either of subst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f27b7f488f3a53677836e1b8e5b2722d
https://doi.org/10.1016/j.apsb.2020.09.007
https://doi.org/10.1016/j.apsb.2020.09.007
Publikováno v:
Biological Research, Vol 42, Iss 2, Pp 217-222 (2009)
Several studies revealed a similar down-regulation of telomeric repeat binding factor 1 (TRF1) in tumors. We have previously reported the TRFl expression levels were down-regulation in non-small cell lung cancer (NSCLC). The regulation of TRFl locali
Externí odkaz:
https://doaj.org/article/1717f243467d48eeb5290de3328b24b7
Longevity is determined by diverse signaling pathways including telomere protection and homeostasis master regulators like FOXO3a. We previously showed that the telomeric repeat binding factor 2 (TRF2) expression decreases with age in human skeletal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b05f67cdd592f8b06a97a85fd8468ec5
https://doi.org/10.1101/2021.08.04.454762
https://doi.org/10.1101/2021.08.04.454762
Akademický článek
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Autor:
Asha S. Multani, Mustafa Ozen, Satya Narayad, Virendra Kumar, Joya Chandra, David J. McConkey, Robert A. Newman, Sen Pathak
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 2, Iss 4, Pp 339-345 (2000)
Chromosomal abnormalities involving telomeric associations (TAs) often precede replicative senescence and abnormal chromosome configurations. We report here that telomere cleavage following exposure to proapoptotic agents is an early event in apoptos
Externí odkaz:
https://doaj.org/article/08c6aef8688043ccb6029954b648c5e1