3D Telomere Structure Analysis to Detect Genomic Instability and Cytogenetic Evolution in Myelodysplastic Syndromes

Autor: Aline Rangel-Pozzo, Daiane Corrêa de Souza, Ana Teresa Schmid-Braz, Ana Paula de Azambuja, Thais Ferraz-Aguiar, Tamara Borgonovo, Sabine Mai

Publikováno v: Cells, Vol 8, Iss 4, p 304 (2019)

The disease course of myelodysplastic syndromes (MDS) features chromosome instability and clonal evolution, leading to the sequential acquisition of novel cytogenetic aberrations and the accumulation of these abnormalities in the bone marrow. Althoug

Externí odkaz: https://doaj.org/article/d59b3dba8155477da93b727530dd2177

Progerin impairs 3D genome organization and induces fragile telomeres by limiting the dNTP pools

Autor: Vincent Piras, Anna Kychygina, Hilda A. Pickett, Joshua A. M. Allen, Jean-Charles Cadoret, Marina Dall’Osto, Laure Crabbe

Publikováno v: Scientific Reports
Scientific Reports, 2021, 11, pp.13195. ⟨10.1038/s41598-021-92631-z⟩
Scientific Reports, Vol 11, Iss 1, Pp 1-20 (2021)
Scientific Reports, Nature Publishing Group, 2021, 11, pp.13195. ⟨10.1038/s41598-021-92631-z⟩

Chromatin organization within the nuclear volume is essential to regulate many aspects of its function and to safeguard its integrity. A key player in this spatial scattering of chromosomes is the nuclear envelope (NE). The NE tethers large chromatin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc40334c67a23b31168e828075fe85f0
https://hal.science/hal-03335051/document

3D Telomere Structure Analysis to Detect Genomic Instability and Cytogenetic Evolution in Myelodysplastic Syndromes

Autor: Daiane Corrêa de Souza, Tamara Borgonovo, Ana Paula de Azambuja, Ana Teresa Schmid-Braz, Sabine Mai, Aline Rangel-Pozzo, Thais Ferraz-Aguiar

Publikováno v: Cells
Volume 8
Issue 4
Cells, Vol 8, Iss 4, p 304 (2019)

The disease course of myelodysplastic syndromes (MDS) features chromosome instability and clonal evolution, leading to the sequential acquisition of novel cytogenetic aberrations and the accumulation of these abnormalities in the bone marrow. Althoug

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::010aed4b8e4e1d55d4826f462bab314c
http://europepmc.org/articles/PMC6526472

Identification and characterization of critical genes associated with tamoxifen resistance in breast cancer

Autor: Ge Qin, Fei Xu, Kuikui Jiang, Shusen Wang, Qianyi Lu, Ruoxi Hong, Wen Xia, Qinglian Zhai, Kai Zhang, Qiufan Zheng, Kaping Lee

Publikováno v: PeerJ

Background Tamoxifen resistance in breast cancer is an unsolved problem in clinical practice. The aim of this study was to determine the potential mechanisms of tamoxifen resistance through bioinformatics analysis. Methods Gene expression profiles of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::083227f7ebf529bb2ae801ef6c9faed2
https://pubmed.ncbi.nlm.nih.gov/33335811

Systematic identification of lincRNA‐based prognostic biomarkers by integrating lincRNA expression and copy number variation in lung adenocarcinoma

Autor: Jing Bai, Li Wang, Hongying Zhao, Yunpeng Zhang, Jing Li, Yingqi Xu, Xia Li, Yulan Deng, Chunyu Deng, Yun Xiao

Publikováno v: International Journal of Cancer. 144:1723-1734

Copy number alterations (CNAs) of lincRNAs act as one of important mechanisms in disrupting lincRNA expression which may play critical roles during tumorigenesis in lung adenocarcinoma (LUAD). The copy number alterations of lincRNAs can mark the spec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14f89dd5b077500556b149debbea07b4
https://doi.org/10.1002/ijc.31865