Zobrazeno 1 - 10
of 227
pro vyhledávání: '"Telomerase reverse transcriptase (TERT)"'
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Immunosenescence impacts both the innate and adaptive immune systems, predominantly affecting certain immune cell types. A notable manifestation of immunosenescence is the diminished efficacy of adaptive immunity. The excessive senescence of immune c
Externí odkaz:
https://doaj.org/article/ec485cf3bb8346a68aceb3a0c9577e4f
Autor:
Michiko Matsuse, Norisato Mitsutake
Publikováno v:
Endocrine Journal, Vol 70, Iss 11, Pp 1035-1049 (2023)
TERT promoter mutations (TERT-p mutations) have been found in many types of cancer and have emerged to play critical roles in tumor progression. The mutations upregulate TERT transcription, and TERT not only elongates telomeres and confers unlimited
Externí odkaz:
https://doaj.org/article/3d1d60a7c28941d19f207257e6d5fdbd
Prognostic value and immune landscapes of TERT promoter methylation in triple negative breast cancer
Autor:
Fei Lin, Jiajia Huang, Wancui Zhu, Tongchao Jiang, Jia Guo, Wen Xia, Miao Chen, Ling Guo, Wuguo Deng, Huanxin Lin
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundTreatment options for patients with triple-negative breast cancer (TNBC) remain limited to mainstay therapies owing to a lack of efficacious therapeutic targets. Accordingly, there is an urgent need to discover and identify novel molecular
Externí odkaz:
https://doaj.org/article/c26b6962b53343aa8f16f7d12d40316a
Autor:
Alexandra Primak, Natalia Kalinina, Mariya Skryabina, Vladimir Usachev, Vadim Chechekhin, Maksim Vigovskiy, Elizaveta Chechekhina, Nikita Voloshin, Konstantin Kulebyakin, Maria Kulebyakina, Olga Grigorieva, Pyotr Tyurin-Kuzmin, Nataliya Basalova, Anastasia Efimenko, Stalik Dzhauari, Yulia Antropova, Ivan Plyushchii, Zhanna Akopyan, Veronika Sysoeva, Vsevolod Tkachuk, Maxim Karagyaur
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 4, p 2421 (2024)
Multipotent mesenchymal stromal cells (MSCs) integrate hormone and neuromediator signaling to coordinate tissue homeostasis, tissue renewal and regeneration. To facilitate the investigation of MSC biology, stable immortalized cell lines are created (
Externí odkaz:
https://doaj.org/article/67d9e65d80e24d7f98f26b324aa8d673
Akademický článek
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Autor:
Tsung-Jang Yeh, Chi-Wen Luo, Jeng-Shiun Du, Chien-Tzu Huang, Min-Hung Wang, Tzer-Ming Chuang, Yuh-Ching Gau, Shih-Feng Cho, Yi-Chang Liu, Hui-Hua Hsiao, Li-Tzong Chen, Mei-Ren Pan, Hui-Ching Wang, Sin-Hua Moi
Publikováno v:
Biomedicines, Vol 11, Iss 3, p 691 (2023)
Head and neck cancers (HNCs) are among the ten leading malignancies worldwide. Despite significant progress in all therapeutic modalities, predictive biomarkers, and targeted therapies for HNCs are limited and the survival rate is unsatisfactory. The
Externí odkaz:
https://doaj.org/article/4ed27ffb8415412c8bc1882fbbe58848
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 1825 (2023)
Telomerase reverse transcriptase (TERT) plays a key role in the maintenance of telomere DNA length. The rs10069690 single nucleotide variant, located in intron 4 of TERT, was found to be associated with telomere length and the risk of estrogen recept
Externí odkaz:
https://doaj.org/article/99d2345cc9a845cd8685ca8402ddbd04
Autor:
Gh. Rasool Bhat, Amrita Bhat, Sonali Verma, Itty Sethi, Ruchi Shah, Varun Sharma, Khursheed A. Dar, Deepak Abrol, Subiya Kaneez, Sandeep Kaul, Ramesh Ganju, Rakesh Kumar
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-8 (2019)
Abstract Background Telomere genetics has recently been emerged as an important field in molecular oncology. Various genome-wide association studies in different population groups have revealed that polymorphisms in Telomere maintenance gene (TERT) g
Externí odkaz:
https://doaj.org/article/2a8430d296664832b40167989cefbd89
Autor:
Yanxiu Li, Iokfai Cheang, Zhongwen Zhang, Wenming Yao, Yanli Zhou, Haifeng Zhang, Yun Liu, Xiangrong Zuo, Xinli Li, Quan Cao
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
BackgroundTelomere length and telomerase are associated in development of cardiovascular diseases. Study aims to investigate the associations of TERC and TERT gene polymorphism and leukocyte telomere length (LTL) in the prognosis of acute heart failu
Externí odkaz:
https://doaj.org/article/8e794b6af68a4348a7d49a979c6ddc98
Autor:
Marta Dratwa, Barbara Wysoczanska, Wioletta Brankiewicz, Martyna Stachowicz-Suhs, Joanna Wietrzyk, Rafał Matkowski, Marcin Ekiert, Jolanta Szelachowska, Adam Maciejczyk, Mariusz Szajewski, Maciej Baginski, Katarzyna Bogunia-Kubik
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 9, p 5164 (2022)
The molecular mechanisms of telomerase reverse transcriptase (TERT) upregulation in breast cancer (BC) are complex. We compared genetic variability within TERT and telomere length with the clinical data of patients with BC. Additionally, we assessed
Externí odkaz:
https://doaj.org/article/07bb022c63fe46f2b8d2af97677270c3