Zobrazeno 1 - 10
of 378
pro vyhledávání: '"Telomerase inhibition"'
Limitations of radiosensitization by direct telomerase inhibition to treat high-risk medulloblastoma
Autor:
Satarupa Sengupta, Shiva Senthil Kumar, Kathryn Bondra, Matthew Sobo, Xiaokui Mo, Rachid Drissi
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Medulloblastoma (MB) is the most common malignant pediatric brain tumor. Previous studies have elucidated the genomic landscape of MB leading to the recognition of four core molecular subgroups (WNT, SHH, group 3 and group 4) with distinct clinical o
Externí odkaz:
https://doaj.org/article/f6997fbab70b46dfbd4aaa9619efc25a
Publikováno v:
Molecules, Vol 28, Iss 17, p 6318 (2023)
Since the occurrence of tumours is closely associated with the telomerase function and oncogene expression, the structure of such enzymes and genes are being recognized as targets for new anticancer drugs. The efficacy of several ligands in telomeras
Externí odkaz:
https://doaj.org/article/683c0364f53c4e4d9d20de602ea52544
Autor:
Eltayeb E. M. Eid, Salah Abdalrazak Alshehade, Amer A. Almaiman, Sareh Kamran, Vannajan Sanghiran Lee, Mohammed Abdullah Alshawsh
Publikováno v:
Biomedicines, Vol 11, Iss 7, p 1891 (2023)
Leukemia, a condition characterized by the abnormal proliferation of blood cells, poses significant challenges in cancer treatment. Thymoquinone (TQ), a bioactive compound derived from black seed, has demonstrated anticancer properties, including tel
Externí odkaz:
https://doaj.org/article/9d9d8485fb6343eab7dd1f4f02507f34
Akademický článek
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Autor:
Saadiya Zia, Komal Tehreem, Sidra Batool, Mehreen Ishfaq, Shaher Bano Mirza, Shahrukh Khan, Majed N. Almashjary, Mohannad S. Hazzazi, Husam Qanash, Ahmad Shaikh, Roua S. Baty, Ibrahim Jafri, Nouf H. Alsubhi, Ghadeer I. Alrefaei, Rokayya Sami, Ramla Shahid
Publikováno v:
Biomedicines, Vol 10, Iss 11, p 2985 (2022)
The epithelial cell adhesion molecule (EpCAM) is considered an essential proliferation signature in cancer. In the current research study, qPCR induced expression of EpCAM was noted in acute lymphoblastic leukemia (ALL) cases. Costunolide, a sesquite
Externí odkaz:
https://doaj.org/article/50cd784e1af0431489a8957bfdccaf70
Autor:
Borges, Gustavo
Les extrémités des chromosomes eucaryotes ressemblent à une cassure double brin et, en tant que telles, peuvent conduire à l'activation indésirable de la réponse aux dommages de l'ADN. Les télomères sont une structure ribonucléoprotéique qu
Autor:
Chiaki Fujiwara, Yukiko Muramatsu, Megumi Nishii, Kazuhiro Tokunaka, Hidetoshi Tahara, Masaru Ueno, Takao Yamori, Yoshikazu Sugimoto, Hiroyuki Seimiya
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Abstract Telomere maintenance by telomerase activity supports the infinite growth of cancer cells. MST-312, a synthetic telomerase inhibitor, gradually shortens telomeres at non-acute lethal doses and eventually induces senescence and apoptosis of te
Externí odkaz:
https://doaj.org/article/bcff0d57a37a40e7bac59241a17f8c5f
Autor:
Alshawsh, Eltayeb E. M. Eid, Salah Abdalrazak Alshehade, Amer A. Almaiman, Sareh Kamran, Vannajan Sanghiran Lee, Mohammed Abdullah
Publikováno v:
Biomedicines; Volume 11; Issue 7; Pages: 1891
Leukemia, a condition characterized by the abnormal proliferation of blood cells, poses significant challenges in cancer treatment. Thymoquinone (TQ), a bioactive compound derived from black seed, has demonstrated anticancer properties, including tel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::d72b246d0f5f9e1e87c2cd53d05f23d4
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
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Autor:
Loukiani Savva, Savvas N. Georgiades
Publikováno v:
Molecules, Vol 26, Iss 4, p 841 (2021)
G-quadruplexes, a family of tetraplex helical nucleic acid topologies, have emerged in recent years as novel targets, with untapped potential for anticancer research. Their potential stems from the fact that G-quadruplexes occur in functionally-impor
Externí odkaz:
https://doaj.org/article/53a0808db715432e82e755ea0da3655e