Zobrazeno 1 - 10
of 1 595
pro vyhledávání: '"Telomerase RNA component"'
Publikováno v:
Molecular Medicine, Vol 29, Iss 1, Pp 1-10 (2023)
Abstract The telomerase RNA component (TERC) gene plays an important role in telomerase-dependent extension and maintenance of the telomeres. In the event of TERC haploinsufficiency, telomere length is often affected; this, in turn, can result in the
Externí odkaz:
https://doaj.org/article/128b3885f075411c8a3c5042722c26e4
Autor:
Yanxiu Li, Iokfai Cheang, Zhongwen Zhang, Wenming Yao, Yanli Zhou, Haifeng Zhang, Yun Liu, Xiangrong Zuo, Xinli Li, Quan Cao
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
BackgroundTelomere length and telomerase are associated in development of cardiovascular diseases. Study aims to investigate the associations of TERC and TERT gene polymorphism and leukocyte telomere length (LTL) in the prognosis of acute heart failu
Externí odkaz:
https://doaj.org/article/8e794b6af68a4348a7d49a979c6ddc98
Publikováno v:
Indian Journal of Dental Research, Vol 28, Iss 5, Pp 574-584 (2017)
Background: The distinguishing feature of cancer cells is their ability to proliferate indefinitely, which is in contrast to the restricted cell multiplication potential for somatic cells. A better understanding of this contrasting behavior was provi
Externí odkaz:
https://doaj.org/article/c888a45590c647b3862efc42280f9bf1
Autor:
Kexiong Zhang, Lihui Wang, Xiaojing Hong, Hao Chen, Yao Shi, Yingying Liu, Jun Liu, Jun-Ping Liu
Publikováno v:
Cells, Vol 10, Iss 11, p 2892 (2021)
Pulmonary premature ageing and fibrogenesis as in idiopathic pulmonary fibrosis (IPF) occur with the DNA damage response in lungs deficient of telomerase. The molecular mechanism mediating pulmonary alveolar cell fates remains to be investigated. The
Externí odkaz:
https://doaj.org/article/3e301ecbf0ea4147a29a613f97fe8786
Autor:
Isabel Córdova-Oriz, Guillermo De Alba, Alberto Pacheco, Alba M. Polonio, Laura Jiménez-Tormo, Elisa Varela, Lucía Chico-Sordo, Marta Medrano, Juan A. Garcia-Velasco, Carlos Balmori
Publikováno v:
REPRODUCTIVE BIOMEDICINE
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
How do age and normo- or oligoasthenozoospermia affect telomere length dynamics in spermatozoa and blood?Sperm and blood samples were collected from a cohort of 37 men aged 25 and under and 40 men aged 40 and over, with either normozoospermia (NZ) or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ac2926b551b68f0f76d18947e5b137f
https://doi.org/10.1016/j.rbmo.2021.10.010
https://doi.org/10.1016/j.rbmo.2021.10.010
Autor:
Isaac Oluwole Adediji, O A Olaniyan, T F Jegede, O J Idowu, Paul Adepoju, Ayodele Ademola Adelakun, Adeolu Sunday Oluremi
Publikováno v:
Journal of Immunoassay and Immunochemistry. 43:299-307
Hepatitis B viral infection could be complicated by hepatocellular degeneration, liver cirrhosis, and cancer. A total of 87 participants - 29 each of symptomatic and asymptomatic hepatitis B positive, and hepatitis B negative individuals (controls) -
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58bc9d47636a873d9175db85786223f0
https://doi.org/10.1080/15321819.2021.2004162
https://doi.org/10.1080/15321819.2021.2004162
Publikováno v:
Nucleic Acid Therapeutics. 31:341-350
Imetelstat (GRN163L) is a potent and specific telomerase inhibitor currently in clinical development for the treatment of hematological malignancies such as myelofibrosis and myelodysplastic syndrome. It is a 13-mer N3'-P5' thio-phosphoramidate oligo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac87bf25b1a074506880d7bb9417fdd0
https://doi.org/10.1089/nat.2020.0918
https://doi.org/10.1089/nat.2020.0918
Autor:
Ekta Khattar, Kavita Gala
Publikováno v:
Cancer Letters. 502:120-132
Long non-coding RNAs (lncRNAs) are known to regulate various biological processes including cancer. Cancer cells possess limitless replicative potential which is attained by telomere length maintenance while normal somatic cells have a limited lifesp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5fc2e6a6bc734be53de72883d10b1c3
https://doi.org/10.1016/j.canlet.2020.12.036
https://doi.org/10.1016/j.canlet.2020.12.036
Autor:
Xiaojing Hong, Hao Chen, Kexiong Zhang, Yao Shi, Jun-Ping Liu, Yingying Liu, Jun Liu, Lihui Wang
Publikováno v:
Cells, Vol 10, Iss 2892, p 2892 (2021)
Cells
Volume 10
Issue 11
Cells
Volume 10
Issue 11
Pulmonary premature ageing and fibrogenesis as in idiopathic pulmonary fibrosis (IPF) occur with the DNA damage response in lungs deficient of telomerase. The molecular mechanism mediating pulmonary alveolar cell fates remains to be investigated. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cb294711851301eb402c974c6e3f937
https://www.mdpi.com/2073-4409/10/11/2892
https://www.mdpi.com/2073-4409/10/11/2892
Autor:
Hao Chen, Kexiong Zhang, Jun Liu, Jun-Ping Liu, Yingying Liu, Lihui Wang, Xiaojing Hong, Yao Shi
Publikováno v:
Clinical and Experimental Pharmacology and Physiology. 48:651-659
Pulmonary senescence and fibrosis occur with deoxyribonucleic acid (DNA) damage response in the lungs deficient of telomerase. The molecular mechanism mediating pulmonary alveolar cell fates remains to be investigated. The present study shows that pu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12ed3eceafb8664a96860e4fe05dae81
https://doi.org/10.1111/1440-1681.13472
https://doi.org/10.1111/1440-1681.13472