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Fruticuline A, a chemically-defined diterpene, exerts antineoplastic effects in vitro and in vivo by multiple mechanisms.

Autor: Corso CR; Department of Pharmacology, Biological Sciences Sector, Federal University of Parana - UFPR, PO Box 19031, Curitiba, PR, 81531-980, Brazil.; Faculdades Pequeno Príncipe, Instituto de Pesquisa Pelé Pequeno Príncipe, Curitiba, PR, Brazil., Stipp MC; Department of Pharmacology, Biological Sciences Sector, Federal University of Parana - UFPR, PO Box 19031, Curitiba, PR, 81531-980, Brazil., Radulski DR; Department of Pharmacology, Biological Sciences Sector, Federal University of Parana - UFPR, PO Box 19031, Curitiba, PR, 81531-980, Brazil., Mariott M; Postgraduate Program in Pharmaceutical Sciences, University Vale of Itajaí, Itajaí, SC, Brazil., da Silva LM; Postgraduate Program in Pharmaceutical Sciences, University Vale of Itajaí, Itajaí, SC, Brazil., de Souza Ramos EA; Pathology Department, Federal University of Parana, Curitiba, PR, Brazil., Klassen G; Pathology Department, Federal University of Parana, Curitiba, PR, Brazil., Queiroz Telles JE; Medical Pathology Department, Federal University of Parana, Curitiba, PR, Brazil., Oliveira CS; Chemistry Department, Federal University of Parana, Curitiba, PR, Brazil., Stefanello MÉA; Chemistry Department, Federal University of Parana, Curitiba, PR, Brazil., Verhoeven AJ; Academic Medical Center, Tytgat Institute for Liver and Intestinal Research, Amsterdam, The Netherlands., Oude Elferink RPJ; Academic Medical Center, Tytgat Institute for Liver and Intestinal Research, Amsterdam, The Netherlands., Acco A; Department of Pharmacology, Biological Sciences Sector, Federal University of Parana - UFPR, PO Box 19031, Curitiba, PR, 81531-980, Brazil. aleacco@ufpr.br.

Publikováno v: Scientific reports [Sci Rep] 2020 Oct 05; Vol. 10 (1), pp. 16477. Date of Electronic Publication: 2020 Oct 05.

Maternal and fetal outcome of pregnancy in Swiss mice infected with Plasmodium berghei ANKA ^GFP .

Autor: Boareto AC; Department of Pharmacology, Federal University of Paraná, Centro Politécnico, PO Box 19031, Curitiba, PR, 81531-980, Brazil. Electronic address: boaretoana@gmail.com., Gomes C; Department of Pharmacology, Federal University of Paraná, Centro Politécnico, PO Box 19031, Curitiba, PR, 81531-980, Brazil., Centeno Müller J; Department of Pharmacology, Federal University of Paraná, Centro Politécnico, PO Box 19031, Curitiba, PR, 81531-980, Brazil., da Silva JG; Department of Pharmacology, Federal University of Paraná, Centro Politécnico, PO Box 19031, Curitiba, PR, 81531-980, Brazil; Department of Chemistry and Biology, Federal University of Technology - Paraná, Cidade Industrial, Curitiba, PR, 81020-430, Brazil., Vergara F; Department of Pharmacology, Federal University of Paraná, Centro Politécnico, PO Box 19031, Curitiba, PR, 81531-980, Brazil., Salum N; Department of Pharmacology, Federal University of Paraná, Centro Politécnico, PO Box 19031, Curitiba, PR, 81531-980, Brazil., Maristany Sargaço R; Department of Pharmacology, Federal University of Paraná, Centro Politécnico, PO Box 19031, Curitiba, PR, 81531-980, Brazil., de Carvalho RR; Laboratory of Environmental Toxicology, National School of Public Health, Oswaldo Cruz Foundation, Manguinhos, Rio de Janeiro, RJ, 21041-210, Brazil., Queiroz Telles JE; Department of Medical Pathology, Federal University of Paraná, Curitiba, PR, 80060-000, Brazil., Marinho CRF; Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, Butantã, São Paulo, SP, 03178-200, Brazil., Paumgartten FJR; Laboratory of Environmental Toxicology, National School of Public Health, Oswaldo Cruz Foundation, Manguinhos, Rio de Janeiro, RJ, 21041-210, Brazil., Dalsenter PR; Department of Pharmacology, Federal University of Paraná, Centro Politécnico, PO Box 19031, Curitiba, PR, 81531-980, Brazil.

Publikováno v: Reproductive toxicology (Elmsford, N.Y.) [Reprod Toxicol] 2019 Oct; Vol. 89, pp. 107-114. Date of Electronic Publication: 2019 Jul 13.

Necroptosis mediates the antineoplastic effects of the soluble fraction of polysaccharide from red wine in Walker-256 tumor-bearing rats.

Autor: Stipp MC; Department of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil., Bezerra IL; Department of Biochemistry and Molecular Biology, Federal University of Paraná, Curitiba, PR, Brazil., Corso CR; Department of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil., Dos Reis Livero FA; Department of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil., Lomba LA; Department of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil., Caillot AR; Department of Biochemistry and Molecular Biology, Federal University of Paraná, Curitiba, PR, Brazil., Zampronio AR; Department of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil., Queiroz-Telles JE; Department of Medical Pathology, Federal University of Paraná, Curitiba, PR, Brazil., Klassen G; Department of Basic Pathology, Federal University of Paraná, Curitiba, PR, Brazil., Ramos EA; Department of Basic Pathology, Federal University of Paraná, Curitiba, PR, Brazil., Sassaki GL; Department of Biochemistry and Molecular Biology, Federal University of Paraná, Curitiba, PR, Brazil., Acco A; Department of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil. Electronic address: aleacco@ufpr.br.

Publikováno v: Carbohydrate polymers [Carbohydr Polym] 2017 Mar 15; Vol. 160, pp. 123-133. Date of Electronic Publication: 2016 Dec 21.

Hydroethanolic extract of Baccharis trimera ameliorates alcoholic fatty liver disease in mice.

Autor: Lívero FA; Department of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil., Martins GG; Department of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil., Queiroz Telles JE; Department of Medical Pathology, Federal University of Paraná, Curitiba, PR, Brazil., Beltrame OC; Department of Veterinary Medicine, Federal University of Paraná, Curitiba, PR, Brazil., Petris Biscaia SM; Department of Cell Biology, Federal University of Paraná, Curitiba, PR, Brazil., Cavicchiolo Franco CR; Department of Cell Biology, Federal University of Paraná, Curitiba, PR, Brazil., Oude Elferink RP; Tytgat Institute for Liver and Intestinal Research, University of Amsterdam, Amsterdam, The Netherlands., Acco A; Department of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil. Electronic address: aleacco@ufpr.br.

Publikováno v: Chemico-biological interactions [Chem Biol Interact] 2016 Dec 25; Vol. 260, pp. 22-32. Date of Electronic Publication: 2016 Oct 15.