Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Telih Boyiri"'
Autor:
Yuan-Wan Sun, Telih Boyiri, Michael Khmelnitsky, Joseph B. Guttenplan, Shantu Amin, Jacek Krzeminski, Karam El-Bayoumy
Publikováno v:
Chemical Research in Toxicology. 22:1992-1997
The environmental pollutant 6-nitrochrysene (6-NC) is a powerful mammary carcinogen and mutagen in rats. Our previous studies have shown that 6-NC is metabolized to trans-1,2-dihydroxy-1,2-dihydro-6-nitrochrysene (1,2-DHD-6-NC) in rats and in several
Autor:
Kun Ming Chen, Joseph B. Guttenplan, Thomas E. Spratt, Zonglin Zhao, James D. Bortner, Joel L. Schwartz, John P. Richie, Arunangshu Das, Telih Boyiri, Peter G. Sacks, Karam El-Bayoumy, Jyh Ming Lin, Ana Calcagnotto, Shantu Amin
Publikováno v:
Biochemical and Biophysical Research Communications. 383:151-155
Tobacco smoking is an important cause of human oral squamous cell carcinoma (SCC). Tobacco smoke contains multiple carcinogens include polycyclic aromatic hydrocarbons typified by benzo[a]pyrene (B[a]P). Surgery is the conventional treatment approach
Autor:
Shantu Amin, William T. Padgett, Telih Boyiri, Arun Sharma, Jyh Ming Lin, Karam El-Bayoumy, Guy R. Lambert, Stephen Nesnow, Leon C. King, Jacek Krzeminski
Publikováno v:
Chemical Research in Toxicology. 17:1591-1599
The environmental pollutant 6-nitrochrysene (6-NC) is a potent carcinogen in several animal models including the rat mammary gland. 6-NC can be activated to intermediates that can damage DNA by simple nitroreduction, ring oxidation, or a combination
Autor:
Telih Boyiri, Wieslawa Kosinska, Karam El-Bayoumy, Dhimant Desai, Brian Pittman, Jyh Ming Lin, Joseph B. Guttenplan, Shantu Amin, Michael Khmelnitsky
Publikováno v:
Carcinogenesis. 25:637-643
We determined the mutant fractions (MF) and mutational specificities in the cII gene in histologically confirmed normal, non-involved and tumor mammary tissues of female transgenic (Big Blue F344 x Sprague-Dawley)F1 rats treated with the environmenta
Autor:
Karam El-Bayoumy, Daniel W. Nixon, Shantu Amin, Dhimant Desai, Telih Boyiri, Joanna M. Leszczynska
Publikováno v:
International Journal of Cancer. 100:395-400
The environmental pollutant 6-nitrochrysene (6-NC) is a potent mammary carcinogen in the rat. To determine if the results obtained in 6-NC-treated rodents can be applicable to humans, we examined its metabolic activation in primary cultures of human
Autor:
Matthew Bologna, Brian Pittman, Dietrich Hoffmann, Gerhard Leder, Neil Trushin, Shobha Akerkar, Karam El-Bayoumy, Telih Boyiri, Hans G. Beger, Doris Henne-Bruns, A. John Cunningham, Stephen Colosimo, Bogdan Prokopczyk, Dhimant Desai, Marco Ramadani, Shantu Amin
Publikováno v:
Chemical Research in Toxicology. 15:677-685
Cancer of the pancreas is the fourth leading cause of cancer mortality in the USA with an estimated 28 900 deaths in 2001. Several factors have been implicated in the etiology of this disease. However, at present, only cigarette smoking has been posi
Autor:
Ceaser Aliaga, Jacek Krzeminski, Telih Boyiri, Timothy K. Cooper, Yuan-Wan Sun, Kun Ming Chen, Arthur Berg, Zhong Lin Zhao, Shantu Amin, Wieslawa Kosinska, Joseph B. Guttenplan, Karam El-Bayoumy
Publikováno v:
Chemical research in toxicology. 26(4)
The mechanisms that can account for the remarkable mammary carcinogenicity of the environmental pollutant 6-nitrochrysene (6-NC) in the rat remain elusive. In our previous studies, we identified several 6-NC-derived DNA adducts in the rat mammary gla
Autor:
Martin K. Safo, Telih Boyiri, Richmond Danso-Danquah, Claude Poyart, Jean Kister, Donald J. Abraham
Publikováno v:
Biochemistry. 34:15021-15036
Four new series of monoaldehyde bisacids and bisaldehyde bisacids with varying chain lengths have been synthesized and evaluated as allosteric effectors of hemoglobin. Molecular modeling, oxygen equilibrium, and crystallographic studies were combined
Autor:
Claude Poyart, Donald J. Abraham, Richmond Danso-Danquah, Telih Boyiri, Jean Kister, Martin K. Safo
Publikováno v:
Biochemistry. 34:15006-15020
Monoaldehyde allosteric effectors of hemoglobin were designed, using molecular modeling software (GRID), to form a Schiff base adduct with the Val 1 alpha N-terminal nitrogens and interact via a salt bridge with Arg 141 alpha of the opposite subunit.
Publikováno v:
International Journal of Oncology. 35
Epidemiological and preclinical studies suggest that environmental factors, hormonal responses and lifestyle, including diet and physical inactivity, are likely contributors to the initiation and progression of prostate cancer in humans. Although the