A genome-wide immunodetection screen in S. cerevisiae uncovers novel genes involved in lysosomal vacuole function and morphology.

Autor: Florante Ricarte, Rosa Menjivar, Surya Chhun, Tattika Soreta, Lisa Oliveira, Teli Hsueh, Maribeth Serranilla, Editte Gharakhanian

Publikováno v: PLoS ONE, Vol 6, Iss 8, p e23696 (2011)

Vacuoles of yeast Saccharomyces cerevisiae are functionally analogous to mammalian lysosomes. Both are cellular organelles responsible for macromolecular degradation, ion/pH homeostasis, and stress survival. We hypothesized that undefined gene functi

Externí odkaz: https://doaj.org/article/1a26373c8b454fbaad8445c16a829c28

Yeast ENV9 encodes a conserved lipid droplet (LD) short-chain dehydrogenase involved in LD morphology

Autor: Ikha M. Siddiqah, Stephanie M. Cocca, Teli Hsueh, Vanessa Cervantes, Editte Gharakhanian, Surya P. Manandhar

Lipid droplets (LDs) have emerged as dynamic and interactive organelles with important roles in lipid metabolism and membrane biogenesis. Here, we report that Saccharomyces cerevisiae Env9 is a novel conserved oxidoreductase involved in LD morphology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::414f4b04cc90e89b9f7225c5f4d62271
https://europepmc.org/articles/PMC5802364/

Differential sensitivity of melanoma cell lines with BRAFV600E mutation to the specific Raf inhibitor PLX4032

Autor: Narsis Attar, Jonathan E. Zuckerman, Qi Wang, Richard C. Koya, Erika von Euw, Teli Hsueh, Ramin Nazarian, Antoni Ribas, Jonas Nørskov Søndergaard, Laura E. MacConaill, Bartosz Chmielowski, Hooman Sazegar, Paul S. Mischel, Stephen Mok, Begoña Comin-Anduix, Jordi Barretina, Deliang Guo, Roger S. Lo, Sarah M. Kehoe

Publikováno v: Journal of Translational Medicine, Vol 8, Iss 1, p 39 (2010)
Søndergaard, Jonas N; Nazarian, Ramin; Wang, Qi; Guo, Deliang; Hsueh, Teli; Mok, Stephen; et al.(2010). Differential sensitivity of melanoma cell lines with BRAFV600E mutation to the specific raf inhibitor PLX4032. Journal of Translational Medicine, 8(1), 39. doi: http://dx.doi.org/10.1186/1479-5876-8-39. Retrieved from: http://www.escholarship.org/uc/item/04v2t4wb
Journal of Translational Medicine
Søndergaard, J N, Nazarian, R, Wang, Q, Guo, D, Hsueh, T, Mok, S, Sazegar, H, Macconail, L E, Barretina, J G, Kehoe, S M, Attar, N, von Euw, E, Zuckerman, J E, Chmielowski, B, Comin-Anduix, B, Koya, R C, Mischel, P S, Lo, R S & Ribas, A J 2010, ' Differential sensitivity of melanoma cell lines with BRAFV600E mutation to the specific raf inhibitor PLX4032 ', Journal of Translational Medicine, vol. 8 . https://doi.org/10.1186/1479-5876-8-39

Blocking oncogenic signaling induced by the BRAF V600E mutation is a promising approach for melanoma treatment. We tested the anti-tumor effects of a specific inhibitor of Raf protein kinases, PLX4032/RG7204, in melanoma cell lines. PLX4032 decreased

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::840f683e3ac48c95eac77e41bb9ed71b
http://www.translational-medicine.com/content/8/1/39

Antitumor Activity of Rapamycin in a Phase I Trial for Patients with Recurrent PTEN-Deficient Glioblastoma.

Autor: Cloughesy, Tim F., Yoshimoto, Koji, Phioanh Nghiemphu, Brown, Kevin, Dang, Julie, Shaojun Zhu, Teli Hsueh, Yinan Chen, Wei Wang, Youngkin, David, Liau, Linda, Martin, Neil, Becker, Don, Bergsneider, Marvin, Lai, Albert, Green, Richard, Oglesby, Tom, Koleto, Michael, Trent, Jeff, Horvath, Steve

Publikováno v: PLoS Medicine; Jan2008, Vol. 5 Issue 1, pe8, 13p, 1 Diagram, 2 Charts, 3 Graphs