Genome-wide gene-based analyses of weight loss interventions identify a potential role for NKX6.3 in metabolism

Autor: Armand Valsesia, Qiao-Ping Wang, Nele Gheldof, Jérôme Carayol, Hélène Ruffieux, Teleri Clark, Victoria Shenton, Lisa J. Oyston, Gregory Lefebvre, Sylviane Metairon, Christian Chabert, Ondine Walter, Polina Mironova, Paulina Lau, Patrick Descombes, Nathalie Viguerie, Dominique Langin, Mary-Ellen Harper, Arne Astrup, Wim H. Saris, Robert Dent, Greg G. Neely, Jörg Hager

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)

Individuals show large variability in their capacity to lose weight and maintain this weight. Here, the authors perform GWAS in two weight loss intervention cohorts and identify two genetic loci associated with weight loss that are taken forward for

Externí odkaz: https://doaj.org/article/69e3b05bacbb4d4db475ac38f90a9bda

Developing Modern Pain Therapies

Autor: John Manion, Matthew A. Waller, Teleri Clark, Joshua N. Massingham, G. Gregory Neely

Publikováno v: Frontiers in Neuroscience, Vol 13 (2019)

Chronic pain afflicts as much as 50% of the population at any given time but our methods to address pain remain limited, ineffective and addictive. In order to develop new therapies an understanding of the mechanisms of painful sensitization is essen

Externí odkaz: https://doaj.org/article/c8bb90711e1a4b9c81834ad754357378

Genome-wide gene-based analyses of weight loss interventions identify a potential role for NKX6.3 in metabolism

Autor: Teleri Clark, Sylviane Metairon, Patrick Descombes, Nele Gheldof, Joerg Hager, Victoria Shenton, Arne Astrup, Mary-Ellen Harper, Dominique Langin, Ondine Walter, Robert Dent, Hélène Ruffieux, G. Gregory Neely, Qiao-Ping Wang, Nathalie Viguerie, Wim H. M. Saris, Jérôme Carayol, Lisa J. Oyston, Paulina Lau, Gregory Lefebvre, Armand Valsesia, Polina Mironova, Christian Chabert

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Nature Communications
Nature Communications, 10:540, 1-10. Nature Publishing Group
Valsesia, A, Wang, Q-P, Gheldof, N, Carayol, J, Ruffieux, H, Clark, T, Shenton, V, Oyston, L J, Lefebvre, G, Metairon, S, Chabert, C, Walter, O, Mironova, P, Lau, P, Descombes, P, Viguerie, N, Langin, D, Harper, M-E, Astrup, A, Saris, W H, Dent, R, Neely, G G & Hager, J 2019, ' Genome-wide gene-based analyses of weight loss interventions identify a potential role for NKX6.3 in metabolism ', Nature Communications, vol. 10, 540 . https://doi.org/10.1038/s41467-019-08492-8

Hundreds of genetic variants have been associated with Body Mass Index (BMI) through genome-wide association studies (GWAS) using observational cohorts. However, the genetic contribution to efficient weight loss in response to dietary intervention re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fbf029dd2a9714ec429156828dcacb6
https://cris.maastrichtuniversity.nl/en/publications/1efaec5b-5777-415c-8f4a-7de650830749

PGC1α Controls Sucrose Taste Sensitization in Drosophila

Autor: G. Gregory Neely, Zhiduan Su, Thang M. Khuong, David E. James, Mei-Ling Lai, William W. Ja, Scarlet J. Park, Lisa J. Oyston, Qiao-Ping Wang, Man-Tat Lau, Yong Qi Lin, Yan-Chuan Shi, Victoria Shenton, Stephen J. Simpson, Herbert Herzog, Teleri Clark

Publikováno v: Cell Reports, Vol 31, Iss 1, Pp-(2020)

Summary: Perceived palatability of food controls caloric intake. Sweet taste is the primary means of detecting the carbohydrate content of food. Surprisingly, sweet taste sensitivity is responsive to extrinsic factors like diet, and this occurs by un

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::574b91cf966b0499a13b967f04427ca4
http://www.sciencedirect.com/science/article/pii/S2211124720303582

Neuronal

Autor: Lisa J, Oyston, Yong Qi, Lin, Thang M, Khuong, Qiao-Ping, Wang, Man Tat, Lau, Teleri, Clark, G Gregory, Neely

Publikováno v: Cell Stress

Neuronal aging involves a progressive decline in cognitive abilities and loss of motor function. Mutations in human Lamin genes (LMNA, LMNB1, LMNB2) lead to a wide-range of diseases including muscular dystrophy, peripheral neuropathy and progeria. He

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f0368ed6c3ace3fcc66d8f325cca950e
https://pubmed.ncbi.nlm.nih.gov/31225490