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Akademický článek

Dysregulation of junctional adhesion molecule‐A contributes to ethanol‐induced barrier disruption in intestinal epithelial cell monolayers

Autor: Daniel M. Chopyk, Pradeep Kumar, Reben Raeman, Yunshan Liu, Tekla Smith, Frank A. Anania

Publikováno v: Physiological Reports, Vol 5, Iss 23, Pp n/a-n/a (2017)

Abstract Alcohol consumption promotes loss of intestinal barrier function. However, mechanisms by which ethanol affects the tight junction (TJ), the cellular structure responsible for maintaining the gut epithelial barrier, are not well understood. T

Externí odkaz: https://doaj.org/article/7abd71f8b208446e9e02c407d2dcca04

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Akademický článek

Adiponectin agonist ADP355 attenuates CCl4-induced liver fibrosis in mice.

Autor: Pradeep Kumar, Tekla Smith, Khalidur Rahman, Natalie E Thorn, Frank A Anania

Publikováno v: PLoS ONE, Vol 9, Iss 10, p e110405 (2014)

Liver fibrosis is a growing global health problem characterized by excess deposition of fibrillar collagen, and activation of hepatic stellate cells (HSCs). Adiponectin is known to possess anti-fibrotic properties; however a high physiological concen

Externí odkaz: https://doaj.org/article/ce345449511d4fd09b1b4b15741856e1

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Blocking integrin α(4)β(7)-mediated CD4 T cell recruitment to the intestine and liver protects mice from western diet-induced non-alcoholic steatohepatitis

Autor: Aatur D. Singhi, Silvia Liu, Smita S. Iyer, Frank A. Anania, Yunshan Liu, Mark J. Czaja, Tekla Smith, Ravi Prakash Rai, Charles A. Parkos, Chirayu Desai, Biki Gupta, Pradeep Kumar, Asma Nusrat, Reben Raeman, Satdarshan P.S. Monga

Publikováno v: J Hepatol
Journal of hepatology, vol 73, iss 5

Background & Aims The heterodimeric integrin receptor α4β7 regulates CD4 T cell recruitment to inflamed tissues, but its role in the pathogenesis of non-alcoholic steatohepatitis (NASH) is unknown. Herein, we examined the role of α4β7-mediated re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd4ce4b89124e671541d4cc749b5ba0f
https://europepmc.org/articles/PMC7839272/

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Adiponectin inhibits hepatic stellate cell activation by targeting the PTEN/AKT pathway

Autor: Kiran Verma, Tekla Smith, Daniel M. Chopyk, Reben Raeman, Pradeep Kumar, Frank A. Anania, Yunshan Liu

Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1864:3537-3545

Adiponectin inhibits hepatic stellate cell (HSC) activation and subsequent development of liver fibrosis via multiple mechanisms. Phosphatase and tensin homolog deletion 10 (PTEN) plays a crucial role in suppression of HSC activation, but its regulat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7a44221b00d77d0ec031ceda3a68808
https://doi.org/10.1016/j.bbadis.2018.08.012

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Periostin promotes liver fibrogenesis by activating lysyl oxidase in hepatic stellate cells

Autor: Hannah Brink, Daniel M. Chopyk, Yunshan Liu, Tekla Smith, Frank A. Anania, Reben Raeman, Todd Sulchek, Pradeep Kumar

Publikováno v: Journal of Biological Chemistry. 293:12781-12792

Liver fibrosis arises from dysregulated wound healing due to persistent inflammatory hepatic injury. Periostin is a nonstructural extracellular matrix protein that promotes organ fibrosis in adults. Here, we sought to identify the molecular mechanism

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be8fbbbbbcdb56f6fcecfd11176f9345
https://doi.org/10.1074/jbc.ra117.001601

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C/EBP homologous protein modulates liraglutide-mediated attenuation of non-alcoholic steatohepatitis

Autor: Yunshan Liu, Khalidur Rahman, Frank A. Anania, Alton B. Farris, Pradeep Kumar, Natalie E. Thorn, Tekla Smith

Publikováno v: Laboratory investigation; a journal of technical methods and pathology

The CCAAT/enhancer-binding protein (C/EBP) homologous protein (CHOP), a major transcriptional regulator of endoplasmic reticulum (ER) stress-mediated apoptosis, is implicated in lipotoxicity-induced ER stress and hepatocyte apoptosis in non-alcoholic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a71409a3c6e0361843d94e845088838c
http://europepmc.org/articles/PMC4965279

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Saturated fat and cholesterol are critical to inducing murine metabolic syndrome with robust nonalcoholic steatohepatitis

Autor: Saul J. Karpen, Tekla Smith, Frank A. Anania, Jamie E. Mells, Pradeep Kumar, Ping P. Fu

Publikováno v: The Journal of Nutritional Biochemistry. 26:285-292

Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome (MetS). Up to a third of NAFLD subjects are at risk for developing nonalcoholic steatohepatitis (NASH). Many rodent models fail to replicate both MetS and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ead0d2f093afe84e1a3e497128b8514a
https://doi.org/10.1016/j.jnutbio.2014.11.002

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Dysregulation of junctional adhesion molecule-A contributes to ethanol-induced barrier disruption in intestinal epithelial cell monolayers

Autor: Yunshan Liu, Pradeep Kumar, Daniel M. Chopyk, Frank A. Anania, Tekla Smith, Reben Raeman

Publikováno v: Physiological Reports
Physiological Reports, Vol 5, Iss 23, Pp n/a-n/a (2017)

Alcohol consumption promotes loss of intestinal barrier function. However, mechanisms by which ethanol affects the tight junction (TJ), the cellular structure responsible for maintaining the gut epithelial barrier, are not well understood. Three clas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de9fcee70e47ab1dbc28357904f08573
https://pubmed.ncbi.nlm.nih.gov/29208693

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