Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Tekla Hornakova"'
Autor:
Tekla Hornakova, Lorraine Springuel, Julien Devreux, Alexandra Dusa, Stefan N. Constantinescu, Laurent Knoops, Jean-Christophe Renauld
Publikováno v:
Haematologica, Vol 96, Iss 6 (2011)
Background Activating mutations in JAK1 and JAK2 have been described in patients with various hematologic malignancies including acute lymphoblastic leukemia and myeloproliferative neoplasms, leading to clinical trials with JAK inhibitors. While ther
Externí odkaz:
https://doaj.org/article/5ba0a9445fbf44b6b9ef38aca7b163c8
Autor:
Tekla Hornakova, Kristyna Polaskova, Tina Catela Ivkovic, Leos Kren, Sona Adamcova, Ondrej Slaby, Hana Nosková, Karol Pál, Jaroslav Sterba, Peter Múdry, Tomas Merta, Marta Jezova, Michal Kyr
Publikováno v:
Cancers
Cancers, Vol 12, Iss 1, p 230 (2020)
Volume 12
Issue 1
Cancers, Vol 12, Iss 1, p 230 (2020)
Volume 12
Issue 1
Background: Tumor mutational burden (TMB) is an emerging genomic biomarker in cancer that has been associated with improved response to immune checkpoint inhibitors (ICIs) in adult cancers. It was described that variability in TMB assessment is intro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10948863c8c9a851a00e5a8b5f5fe02b
https://doi.org/10.3390/cancers12010230
https://doi.org/10.3390/cancers12010230
Autor:
O. Ragac, M. Bubanova, Tekla Hornakova, Francisco Miguel Lopez Cardoso, D. Petrovajova, M. Tomkova
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 138
The human Dialyzed Leukocyte Extract (DLE) is a heterogeneous mix of oligopeptides of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::344c8f4228aebe7f6bde4de3140d3add
https://pubmed.ncbi.nlm.nih.gov/28189890
https://pubmed.ncbi.nlm.nih.gov/28189890
Autor:
Julien Devreux, Stefan N. Constantinescu, Lorraine Springuel, Tekla Hornakova, Alexandra Dusa, Jean-Christophe Renauld, Laurent Knoops
Publikováno v:
Haematologica : the hematology journal, Vol. 96, no. 6, p. 845-853 (2011)
BACKGROUND: Activating mutations in JAK1 and JAK2 have been described in patients with various hematologic malignancies including acute lymphoblastic leukemia and myeloproliferative neoplasms, leading to clinical trials with JAK inhibitors. While the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6a2d47471be86359d6c4f655be9c5a1
https://doi.org/10.3324/haematol.2010.036350
https://doi.org/10.3324/haematol.2010.036350
Autor:
Stefan N. Constantinescu, Andrea Camera, Robin Foà, Marco Tartaglia, Hélène Cavé, Laurent Knoops, Simone Martinelli, Lorenzo Stella, Francesca Paoloni, Valentina Petrangeli, Valentina Fodale, Simona Tavolaro, Angela Battistini, Cristina Ariola, Giovanni Cazzaniga, Emmanuelle Clappier, Alessandra Fragale, Sabina Chiaretti, Marco Vignetti, Andrea Biondi, Jean-Christophe Renauld, Assunta Tornesello, Bruce D. Gelb, Giovanni Pizzolo, Massimo Sanchez, Monica Messina, Tekla Hornakova, Elisabetta Flex
Publikováno v:
The Journal of Experimental Medicine
The Journal of Experimental Medicine, Vol. 205, no. 4, p. 751-8 (2008)
The Journal of Experimental Medicine, Vol. 205, no. 4, p. 751-8 (2008)
Aberrant signal transduction contributes substantially to leukemogenesis. The Janus kinase 1 (JAK1) gene encodes a cytoplasmic tyrosine kinase that noncovalently associates with a variety of cytokine receptors and plays a nonredundant role in lymphoi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c30bb32405700fe9f55d3fc0982ba402
https://doi.org/10.1084/jem.20072182
https://doi.org/10.1084/jem.20072182
Autor:
Yohan Royer, Laurent Knoops, Tekla Hornakova, Stefan N. Constantinescu, Jean-Christophe Renauld
Publikováno v:
Oncogene. 27:1511-1519
Constitutive activation of the JAK-STAT pathway is frequent in cancer and contributes to oncogenesis. Here, we took advantage of the Ba/F3 cell line, a murine proB cell line dependent on IL-3 for growth, to analyse mechanisms of constitutive STAT act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8c1e4bc57812e61e40394537d01a9d0
https://doi.org/10.1038/sj.onc.1210800
https://doi.org/10.1038/sj.onc.1210800
Autor:
Jean-Christophe Renauld, Elisabetta Flex, Sandrine Degryse, Jan Cools, Laurent Knoops, Tekla Hornakova, Marco Tartaglia, Elisabeth Losdyck, Stefan N. Constantinescu, Olga Gielen, Lorraine Springuel
Publikováno v:
Journal of Biological Chemistry, Vol. 290, no. 48, p. 29022-29034 (2015)
JAK1 and JAK3 are recurrently mutated in acute lymphoblastic leukemia. These tyrosine kinases associate with heterodimeric cytokine receptors such as IL-7 receptor or IL-9 receptor, in which JAK1 is appended to the specific chain, and JAK3 is appende
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1deb3d95fd0dfca2ff6d4dc508b94953
https://hdl.handle.net/2078.1/166226
https://hdl.handle.net/2078.1/166226
Autor:
Stefan N. Constantinescu, Fanny Lambert, Emilie Leroy, Tekla Hornakova, Marco Tartaglia, Jean-Christophe Renauld, Elisabeth Losdyck, Lorraine Springuel, Elisabetta Flex, Laurent Knoops
Publikováno v:
Blood, Vol. 124, no. 26, p. 3924-3931 (2014)
The acquisition of growth signal self-sufficiency is 1 of the hallmarks of cancer. We previously reported that the murine interleukin-9-dependent TS1 cell line gives rise to growth factor-independent clones with constitutive activation of the Janus k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b7b0933515f13970bafa823c05f4edf
https://hdl.handle.net/2078.1/155937
https://hdl.handle.net/2078.1/155937
Autor:
Torsten Haferlach, Stefan N. Constantinescu, Jan Cools, Laurent Knoops, Maria Kleppe, Marco Tartaglia, Robin Foà, Jules P.P. Meijerink, Vahid Asnafi, François Sigaux, Tekla Hornakova, Jean Soulier, Nicole Mentens, Elizabeth Macintyre, Peter Vandenberghe
Publikováno v:
Blood
Blood, American Society of Hematology, 2011, 117, pp.7090-7098
Blood, 117(28), 709-7098. American Society of Hematology
Blood, American Society of Hematology, 2011, 117, pp.7090-7098
Blood, 117(28), 709-7098. American Society of Hematology
We have recently reported inactivation of the tyrosine phosphatase PTPN2 (also known as TC-PTP) through deletion of the entire gene locus in ∼ 6% of T-cell acute lymphoblastic leukemia (T-ALL) cases. T-ALL is an aggressive disease of the thymocytes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78f89770c2dbd2328d2c02d4700c52a2
Autor:
Judith Staerk, Laurent Knoops, Elisabetta Flex, Yohan Royer, Tekla Hornakova, Stefan N. Constantinescu, Marco Tartaglia, Jean-Christophe Renauld
Publikováno v:
The Journal of biological chemistry. 284(11)
Activating mutations in JAK1 have been reported in acute lymphoblastic leukemias, but little is known about the mechanisms involved in their constitutive activation. Here, we studied the ability of JAK1 V658F and A634D to activate the Janus kinase (J
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33bd1976120a4b727e7a725e1116a906
https://pubmed.ncbi.nlm.nih.gov/19139102
https://pubmed.ncbi.nlm.nih.gov/19139102