Novel autoantibody targets identified in patients with autoimmune hepatitis (AIH) by PhIP-Seq reveals pathogenic insights

Autor: Klepper, Arielle, Kung, Andrew, Vazquez, Sara E., Mitchell, Anthea, Mann, Sabrina, Zorn, Kelsey, Avila-Vargas, Isaac, Kari, Swathi, Tekeste, Melawit, Castro, Javier, Lee, Briton, Duarte, Maria, Khalili, Mandana, Yang, Monica, Wolters, Paul, Price, Jennifer, Perito, Emily, Feng, Sandy, Maher, Jacquelyn J., Lai, Jennifer, Weiler-Normann, Christina, Lohse, Ansgar W, DeRisi, Joseph, Tana, Michele

Publikováno v: medRxiv

Autoimmune hepatitis (AIH) is a severe autoimmune disease, characterized by the presence of autoantibodies. However, the role of autoantibodies in the pathophysiology of AIH remains uncertain. Here, we employed Phage Immunoprecipitation-Sequencing (P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ba576869628276e1ecbe0ee831639af2
https://europepmc.org/articles/PMC10312872/

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Novel autoantibody targets identified in patients with autoimmune hepatitis (AIH) by PhIP-Seq reveals pathogenic insights.

Autor: Klepper A; Department of Medicine, University of California, San Francisco, USA.; UCSF Liver Center., Asaki J; Department of Biochemistry, University of California, San Francisco, USA.; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, USA., Kung AF; Department of Biochemistry, University of California, San Francisco, USA., Vazquez SE; Department of Dermatology, Mass General Hospital, Boston, MA., Bodansky A; Department of Pediatrics, University of California, San Francisco, USA., Mitchell A; Chan Zuckerberg Biohub; San Francisco, CA, USA., Mann SA; Department of Biochemistry, University of California, San Francisco, USA.; Chan Zuckerberg Biohub; San Francisco, CA, USA., Zorn K; Department of Biochemistry, University of California, San Francisco, USA., Avila-Vargas I; Department of Medicine, University of California, San Francisco, USA., Kari S; Department of Medicine, University of California, San Francisco, USA., Tekeste M; Department of Medicine, University of California, San Francisco, USA., Castro J; Department of Medicine, University of California, San Francisco, USA., Lee B; Department of Medicine, University of California, San Francisco, USA., Duarte M; Department of Medicine, University of California, San Francisco, USA.; UCSF Liver Center., Khalili M; Department of Medicine, University of California, San Francisco, USA.; UCSF Liver Center., Yang M; Department of Medicine, University of California, San Francisco, USA., Wolters P; Department of Medicine, University of California, San Francisco, USA., Price J; Department of Medicine, University of California, San Francisco, USA.; UCSF Liver Center., Perito E; Department of Pediatrics, University of California, San Francisco, USA.; UCSF Liver Center., Feng S; Department of Surgery, University of California, San Francisco, USA.; UCSF Liver Center., Maher JJ; Department of Medicine, University of California, San Francisco, USA.; UCSF Liver Center., Lai JC; Department of Medicine, University of California, San Francisco, USA.; UCSF Liver Center., Weiler-Normann C; Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Lohse AW; Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., DeRisi J; Department of Biochemistry, University of California, San Francisco, USA.; Chan Zuckerberg Biohub; San Francisco, CA, USA., Tana M; Department of Medicine, University of California, San Francisco, USA.; UCSF Liver Center.

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2024 Oct 29. Date of Electronic Publication: 2024 Oct 29.