Zobrazeno 1 - 10
of 119
pro vyhledávání: '"Tejvir S Khurana"'
Autor:
Natasha Jaiswal, Matthew Gavin, Emanuele Loro, Jaimarie Sostre‐Colón, Paul A. Roberson, Kahealani Uehara, Nicole Rivera‐Fuentes, Michael Neinast, Zoltan Arany, Scot R. Kimball, Tejvir S. Khurana, Paul M. Titchenell
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 13, Iss 1, Pp 495-514 (2022)
Abstract Background Skeletomuscular diseases result in significant muscle loss and decreased performance, paralleled by a loss in mitochondrial and oxidative capacity. Insulin and insulin‐like growth factor‐1 (IGF‐1) are two potent anabolic hor
Externí odkaz:
https://doaj.org/article/762fe12f3fe3495f9e5c9957980465ca
Autor:
Kasturi Sengupta, Manoj K. Mishra, Emanuele Loro, Melissa J. Spencer, April D. Pyle, Tejvir S. Khurana
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 22, Iss , Pp 500-509 (2020)
Utrophin upregulation is considered a promising therapeutic strategy for Duchenne muscular dystrophy (DMD). A number of microRNAs (miRNAs) post-transcriptionally regulate utrophin expression by binding their cognate sites in the 3′ UTR. Previously
Externí odkaz:
https://doaj.org/article/f64263e4308c409eb3a91ac6896b8e59
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Abstract Upregulation of utrophin, a dystrophin related protein, is considered a promising therapeutic approach for Duchenne muscular dystrophy (DMD). Utrophin expression is repressed at the post-transcriptional level by a set of miRNAs, among which
Externí odkaz:
https://doaj.org/article/38c53e90bb2a4eeb93602bc488113deb
Autor:
Steven Yang, Emanuele Loro, Shogo Wada, Boa Kim, Wei-Ju Tseng, Kristina Li, Tejvir S. Khurana, Zoltan Arany
Publikováno v:
Skeletal Muscle, Vol 10, Iss 1, Pp 1-8 (2020)
Abstract PGC-1 (peroxisome-proliferator-activated receptor-γ coactivator-1) alpha is a potent transcriptional coactivator that coordinates the activation of numerous metabolic processes. Exercise strongly induces PGC-1alpha expression in muscle, and
Externí odkaz:
https://doaj.org/article/bb4134d271df46789a140a70766d5d36
Autor:
Sara Bisetto, Megan C. Wright, Romana A. Nowak, Angelo C. Lepore, Tejvir S. Khurana, Emanuele Loro, Nancy J. Philp
Publikováno v:
iScience, Vol 22, Iss , Pp 507-518 (2019)
Summary: Lactate produced by muscle during high-intensity activity is an important end product of glycolysis that supports whole body metabolism. The lactate shuttle model suggested that lactate produced by glycolytic muscle fibers is utilized by oxi
Externí odkaz:
https://doaj.org/article/ce448164eafd4ade9a76cd5e99222414
Autor:
Lenka Dohnalová, Patrick Lundgren, Jamie R. E. Carty, Nitsan Goldstein, Sebastian L. Wenski, Pakjira Nanudorn, Sirinthra Thiengmag, Kuei-Pin Huang, Lev Litichevskiy, Hélène C. Descamps, Karthikeyani Chellappa, Ana Glassman, Susanne Kessler, Jihee Kim, Timothy O. Cox, Oxana Dmitrieva-Posocco, Andrea C. Wong, Erik L. Allman, Soumita Ghosh, Nitika Sharma, Kasturi Sengupta, Belinda Cornes, Nitai Dean, Gary A. Churchill, Tejvir S. Khurana, Mark A. Sellmyer, Garret A. FitzGerald, Andrew D. Patterson, Joseph A. Baur, Amber L. Alhadeff, Eric J. N. Helfrich, Maayan Levy, J. Nicholas Betley, Christoph A. Thaiss
Publikováno v:
Nature. 612:739-747
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f2b1103ca28dba767e72646a911e432
https://doi.org/10.1038/s41586-022-05525-z
https://doi.org/10.1038/s41586-022-05525-z
Autor:
Emanuele Loro, Cholsoon Jang, William J. Quinn, Joseph A. Baur, Zoltan P. Arany, Tejvir S. Khurana
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Lack of interleukin 15 receptor alpha (IL15RA) increases spontaneous activity, exercise capacity and protects from diet-induced obesity by enhancing muscle energy metabolism, suggesting a role as exercise mimetic for IL15RA antagonists. Using control
Externí odkaz:
https://doaj.org/article/310e8f9e3742415c8bd3afe06681ae9c
Autor:
Kahealani Uehara, Paul M. Titchenell, Paul A. Roberson, Nicole Rivera-Fuentes, Tejvir S. Khurana, Michael D. Neinast, Zoltan Arany, Scot R. Kimball, Jaimarie Sostre-Colón, Matthew Gavin, Natasha Jaiswal, Emanuele Loro
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 13, Iss 1, Pp 495-514 (2022)
Background Skeletomuscular diseases result in significant muscle loss and decreased performance, paralleled by a loss in mitochondrial and oxidative capacity. Insulin and insulin‐like growth factor‐1 (IGF‐1) are two potent anabolic hormones tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d440cf8c9327780391f9e44fbfeea4a
https://doi.org/10.1002/jcsm.12846
https://doi.org/10.1002/jcsm.12846
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0182676 (2017)
Duchenne muscular dystrophy (DMD) is a fatal genetic disease caused by an absence of the 427kD muscle-specific dystrophin isoform. Utrophin is the autosomal homolog of dystrophin and when overexpressed, can compensate for the absence of dystrophin an
Externí odkaz:
https://doaj.org/article/0899ddd4785644c69f6546c4fba96533
Publikováno v:
Biology Open, Vol 2, Iss 11, Pp 1245-1252 (2013)
Summary Dysferlin is a member of the evolutionarily conserved ferlin gene family. Mutations in Dysferlin lead to Limb Girdle Muscular Dystrophy 2B (LGMD2B), an inherited, progressive and incurable muscle disorder. However, the molecular mechanisms un
Externí odkaz:
https://doaj.org/article/6ef88cb4ff624a2495946a6051c6699f