Výsledky vyhledávání - "Tejas S. Khire"

Brain endothelial tricellular junctions as novel sites for T cell diapedesis across the blood–brain barrier

Autor: Britta Engelhardt, Guillaume Witz, Jörg Piontek, Isabelle Gruber, Derya Sönmez, Adolfo Odriozola Quesada, Masuo Kondoh, Tejas S. Khire, Tobias Hildbrand, Sasha Soldati, Urban Deutsch, Fabio Bösch, Benoît Zuber, Mariana Castro Dias, James L. McGrath

Publikováno v: Castro Dias, Mariana; Odriozola Quesada, Adolfo; Soldati, Sasha; Bösch, Fabio; Gruber, Isabelle; Hildbrand, Tobias; Sönmez, Derya; Khire, Tejas; Witz, Guillaume; McGrath, James L.; Piontek, Jörg; Kondoh, Masuo; Deutsch, Urban; Zuber, Benoît; Engelhardt, Britta (2021). Brain endothelial tricellular junctions as novel sites for T cell diapedesis across the blood–brain barrier. Journal of cell science, 134(8) Company of Biologists Limited 10.1242/jcs.253880
Journal of Cell Science
article-version (VoR) Version of Record

The migration of activated T cells across the blood–brain barrier (BBB) is a critical step in central nervous system (CNS) immune surveillance and inflammation. Whereas T cell diapedesis across the intact BBB seems to occur preferentially through t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c56b8d76eeb4d02aa5fae7c3692ab4c

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Ultrathin Silicon Membranes for in Situ Optical Analysis of Nanoparticle Translocation across a Human Blood-Brain Barrier Model

Autor: Tejas S. Khire, Yan Yan, Emma Luke, Dale Glavin, Diána Hudecz, James L. McGrath, Morten Nielsen, Kenneth A. Dawson, Henry H. Chung, Laurent Adumeau

Publikováno v: Hudecz, D, Khire, T, Chung, H L, Adumeau, L, Glavin, D, Luke, E, Nielsen, M S, Dawson, K A, McGrath, J L & Yan, Y 2020, ' Ultrathin Silicon Membranes for in Situ Optical Analysis of Nanoparticle Translocation across a Human Blood-Brain Barrier Model ', ACS Nano, vol. 14, no. 1, pp. 1111-1122 . https://doi.org/10.1021/acsnano.9b08870

Here we present a blood-brain barrier (BBB) model that enables high-resolution imaging of nanoparticle (NP) interactions with endothelial cells and the capture of rare NP translocation events. The enabling technology is an ultrathin silicon nitride (

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A predictive model of nanoparticle capture on ultrathin nanoporous membranes

Autor: Kilean Lucas, Mehdi Dehghani, Thomas R. Gaborski, Tejas S. Khire, James L. McGrath, Jonathan Flax, Richard E. Waugh

Publikováno v: Journal of Membrane Science. 633:119357

Beyond their use as separation tools, nanoporous membranes can be used for the capture and analysis of biological nanoparticles such as virus or small extracellular vesicles (sEVs). While the challenges of imaging sub-optical particles can be address

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c65a5dfc88a14a63019be3a619b34615
https://doi.org/10.1016/j.memsci.2021.119357

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Microvascular Mimetics for the Study of Leukocyte-Endothelial Interactions

Autor: James L. McGrath, Alec T. Salminen, Raquel E Ajalik, Angela Glading, Molly C McCloskey, Thomas R. Gaborski, Kilean Lucas, Henry H. Chung, Richard E. Waugh, Harsha Swamy, Tejas S. Khire

Publikováno v: Cell Mol Bioeng

INTRODUCTION: The pathophysiological increase in microvascular permeability plays a well-known role in the onset and progression of diseases like sepsis and atherosclerosis. However, how interactions between neutrophils and the endothelium alter vess

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1aa740821c26edc450b3cae5e3b9d37
https://pubmed.ncbi.nlm.nih.gov/32175026

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Investigating Leukocyte Luminal Dynamics, Diapedesis, and Abluminal Crawling with Optically Transparent Nanoporous Membranes

Autor: James L. McGrath, Thomas R. Gaborski, Tejas S. Khire, Alec T. Salminen, Richard E. Waugh

Publikováno v: D32. ACUTE LUNG INJURY AND ARDS: CLINICAL AND MECHANISTIC STUDIES.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1adc844a1a56218d8641ddcb43624f69
https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a6143

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A silicon nanomembrane platform for the visualization of immune cell trafficking across the human blood–brain barrier under flow

Autor: Fabien Gosselet, Adrien Mossu, Hideaki Nishihara, Britta Engelhardt, Tejas S. Khire, James L. McGrath, Maria Rosito, Federica Sallusto, Henry H. Chung, Lucie Dehouck, Isabelle Gruber, Emma Luke

Publikováno v: Journal of Cerebral Blood Flow and Metabolism
Journal of Cerebral Blood Flow and Metabolism, Nature Publishing Group, 2018, 39 (3), pp.395-410. ⟨10.1177/0271678X18820584⟩
Mossu, Adrien; Rosito, Maria; Khire, Tejas; Li Chung, Hung; Nishihara, Hideaki; Gruber, Isabelle; Luke, Emma; Dehouck, Lucie; Sallusto, Federica; Gosselet, Fabien; McGrath, James L; Engelhardt, Britta (2019). A silicon nanomembrane platform for the visualization of immune cell trafficking across the human blood-brain barrier under flow. Journal of cerebral blood flow and metabolism, 39(3), pp. 395-410. Sage 10.1177/0271678X18820584

International audience; Here we report on the development of a breakthrough microfluidic human in vitro cerebrovascular barrier (CVB) model featuring stem cell-derived brain-like endothelial cells (BLECs) and nanoporous silicon nitride (NPN) membrane

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0168ce40f91711c21f5be97add5249d1
http://hdl.handle.net/11573/1608996

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Finite element modeling to analyze TEER values across silicon nanomembranes

Autor: Maria E. Gracheva, Barrett J. Nehilla, Tejas S. Khire, James L. McGrath, Jirachai Getpreecharsawas, Richard E. Waugh

Publikováno v: Biomedical microdevices. 20(1)

Silicon nanomembranes are ultrathin, highly permeable, optically transparent and biocompatible substrates for the construction of barrier tissue models. Trans-epithelial/endothelial electrical resistance (TEER) is often used as a non-invasive, sensit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::799adf5566b98c63fcc8520b06771191
https://pubmed.ncbi.nlm.nih.gov/29305767

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