Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Tejas R Karhadkar"'
Publikováno v:
PLoS ONE, Vol 16, Iss 1, p e0245924 (2021)
SARS-CoV-2 is a single stranded RNA (ssRNA) virus and contains GU-rich sequences distributed abundantly in the genome. In COVID-19, the infection and immune hyperactivation causes accumulation of inflammatory immune cells, blood clots, and protein ag
Externí odkaz:
https://doaj.org/article/681ddbd13e6046fd83e61726fb66fc83
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0244762 (2020)
Non-alcoholic fatty liver disease (NAFLD) is associated with obesity and type 2 diabetes and is characterized by the accumulation of fat in the liver (steatosis). NAFLD can transition into non-alcoholic steatohepatitis (NASH), with liver cell injury,
Externí odkaz:
https://doaj.org/article/81cb22177e3c4508a70e3c580c204ed5
Publikováno v:
Respiratory Research, Vol 23, Iss 1, Pp 1-12 (2022)
Abstract Background Sialic acid is often the distal sugar on glycoconjugates, and sialidases are enzymes that remove this sugar. In fibrotic lesions in human and mouse lungs, there is extensive desialylation of glycoconjugates, and upregulation of si
Externí odkaz:
https://doaj.org/article/daede1f497744dc4b867b7f035d23b31
Publikováno v:
Am J Pathol
High-fat diet (HFD)–induced inflammation and steatosis of adipose tissue and liver are associated with a variety of serious health risks. Sialic acids are found as the distal terminal sugar on glycoproteins, which are removed by sialidases (neurami
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 376:106-117
The active form of transforming growth factor-β1 (TGF-β1) plays a key role in potentiating fibrosis. TGF-β1 is sequestered in an inactive state by a latency-associated glycopeptide (LAP). Sialidases (also called neuraminidases (NEU)) cleave termin
Autor:
Alexandra J. Trott, Ben J. Greenwell, Tejas R. Karhadkar, Natali N. Guerrero-Vargas, Carolina Escobar, Ruud M. Buijs, Jerome S. Menet
Publikováno v:
BMC Biology. 20
Background Many epidemiological studies revealed that shift work is associated with an increased risk of a number of pathologies, including cardiovascular diseases. An experimental model of shift work in rats has additionally been shown to recapitula
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 318:L165-L179
Pulmonary fibrosis involves the formation of inappropriate scar tissue in the lungs, but what drives fibrosis is unclear. Sialidases (also called neuraminidases) cleave terminal sialic acids from glycoconjugates. In humans and mice, pulmonary fibrosi
Publikováno v:
Am J Pathol
High-fat diet (HFD)-induced inflammation is associated with a variety of health risks. The systemic pentraxin serum amyloid P (SAP) inhibits inflammation. SAP activates the high-affinity IgG receptor Fcγ receptor I (FcγRI; CD64) and the lectin rece
Publikováno v:
International Journal of Molecular Sciences. 24:239
Fibrosing diseases are a major medical problem, and are associated with more deaths per year than cancer in the US. Sialidases are enzymes that remove the sugar sialic acid from glycoconjugates. In this review, we describe efforts to inhibit fibrosis
Autor:
Alexandra J. Trott, Ruud M. Buijs, Natalí N. Guerrero-Vargas, Jerome S. Menet, Tejas R. Karhadkar, Ben J. Greenwell, Carolina Escobar
Many epidemiological studies revealed that shift work is associated with increased risk of cardiovascular diseases. However, the underlying mechanisms remain poorly understood. An experimental model of shift work in rats has been shown to recapitulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e755549320cd0edeaa9aa984ebb677d
https://doi.org/10.1101/2021.05.13.444001
https://doi.org/10.1101/2021.05.13.444001