Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Tejas M. Gupte"'
Autor:
Kelly J. Culhane, Tejas M. Gupte, Indrani Madhugiri, Chetan J. Gadgil, Sivaraj Sivaramakrishnan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
Experimentally validated kinetic simulations uncover transient enhancement of GPCR ternary complex formation by allokairic effectors.
Externí odkaz:
https://doaj.org/article/4c100b14cacb4d8580a81188724aed25
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Recent reports suggest the spatial and temporal coupling of receptor-effector interactions, with the potential to diversify downstream responses. Here authors demonstrate the temporal coupling of cognate and non-cognate G protein interactions through
Externí odkaz:
https://doaj.org/article/09a540a2a875492bb09d5e57994f67b2
Autor:
Tejas M Gupte
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0126829 (2015)
During the cell cycle, mitochondria undergo regulated changes in morphology. Two particularly interesting events are first, mitochondrial hyperfusion during the G(1)-S transition and second, fragmentation during entry into mitosis. The mitochondria r
Externí odkaz:
https://doaj.org/article/3fc16bc6c5c4439dba4b732dab09ae54
Autor:
Kelly J. Culhane, Tejas M. Gupte, Indrani Madhugiri, Chetan J. Gadgil, Sivaraj Sivaramakrishnan
Publikováno v:
Nature communications. 13(1)
Established models of ternary complex formation between hormone, G protein coupled receptor (GPCR), and G protein assume that all interactions occur under equilibrium conditions. However, recent studies have established that the lifetimes of these in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d370b240e3f5b1cfe38101ecb4188ab
https://pubmed.ncbi.nlm.nih.gov/35260563
https://pubmed.ncbi.nlm.nih.gov/35260563
Autor:
Tejas M. Gupte, Shayla Paulekas, Fredrik Sadler, Nagarajan Vaidehi, Matthew Dysthe, Keehun Kim, Sivaraj Sivaramakrishnan, Michael Ritt
Publikováno v:
Proc Natl Acad Sci U S A
Classical pharmacological models have incorporated an "intrinsic efficacy" parameter to capture system-independent effects of G protein-coupled receptor (GPCR) ligands. However, the nonlinear serial amplification of downstream signaling limits quanti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e94e0538ea26c4212daa7e0edd9b4b5
https://europepmc.org/articles/PMC7980469/
https://europepmc.org/articles/PMC7980469/
Publikováno v:
Methods Enzymol
Linkers in Biomacromolecules ISBN: 9780128208182
Linkers in Biomacromolecules ISBN: 9780128208182
ER/K α-helices are a subset of single alpha helical (SAH) domains, which exhibit unusual stability as isolated protein secondary structures. They adopt an elongated structural conformation, while regulating the frequency of interactions between prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::377a6078f3979681f02afdeaa8c82651
https://europepmc.org/articles/PMC8009693/
https://europepmc.org/articles/PMC8009693/
Publikováno v:
Pharmacology Research & Perspectives
Pharmacology Research & Perspectives, Vol 8, Iss 6, Pp n/a-n/a (2020)
Pharmacology Research & Perspectives, Vol 8, Iss 6, Pp n/a-n/a (2020)
While allosteric modulation of GPCR signaling has gained prominence to address the need for receptor specificity, efforts have mainly focused on allosteric sites adjacent to the orthosteric ligand‐binding pocket and lipophilic molecules that target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f640cd68e0e52b1b2bf85c25ea177cbc
https://pubmed.ncbi.nlm.nih.gov/33124765
https://pubmed.ncbi.nlm.nih.gov/33124765
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Despite the crowded nature of the cellular milieu, ligand–GPCR–G protein interactions are traditionally viewed as spatially and temporally isolated events. In contrast, recent reports suggest the spatial and temporal coupling of receptor–effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdb77e10d1a561b18e1e55b5b653e4ed
http://europepmc.org/articles/PMC6811539
http://europepmc.org/articles/PMC6811539
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 114(14)
Although individual G-protein–coupled receptors (GPCRs) are known to activate one or more G proteins, the GPCR–G-protein interaction is viewed as a bimolecular event involving the formation of a ternary ligand–GPCR–G-protein complex. Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0acfe0dc287fed645093a69db590460a
https://pubmed.ncbi.nlm.nih.gov/28325873
https://pubmed.ncbi.nlm.nih.gov/28325873
Publikováno v:
Biophysical Journal. 112:238a
Cargo transport by motor proteins organizes the cell interior. Although structure and mechanics of individual motors has been extensively studied, the regulation of motility by the cargo interface remains poorly understood. Cargo-mediated regulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86f212fb34597430afe32245f11dc086
https://doi.org/10.1016/j.bpj.2016.11.1305
https://doi.org/10.1016/j.bpj.2016.11.1305