Výsledky vyhledávání - "Teisuke, Takahashi"

Akademický článek

Effects of a lysophosphatidic acid receptor 1 antagonist on hypertensive renal injury in Dahl-Iwai salt-sensitive rats

Autor: Takumi Naruse, Hidenori Otake, Teisuke Takahashi

Publikováno v: Journal of Pharmacological Sciences, Vol 149, Iss 4, Pp 179-188 (2022)

Lysophosphatidic acid (LPA) is a biologically active lysophospholipid, and acts on six types of LPA receptors (LPA1-LPA6). LPA-LPA1 signaling has been suggested as a therapeutic target for inflammatory and fibrotic disorders, including renal fibrosis

Externí odkaz: https://doaj.org/article/48e922e160fa435f824451bb9dde2a55

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Discovery of Novel Pyrazolylpyridine Derivatives for 20-Hydroxyeicosatetraenoic Acid Synthase Inhibitors with Selective CYP4A11/4F2 Inhibition

Autor: Madoka Kawamura, Yohei Kobashi, Hiroaki Tanaka, Ayako Bohno-Mikami, Makoto Hamada, Yuji Ito, Takashi Hirata, Hiroki Ohara, Naoki Kojima, Hiroko Koretsune, Emi Gunji, Takuya Fukunaga, Shoko Inatani, Yoshitaka Hasegawa, Akinori Suzuki, Teisuke Takahashi, Hiroyuki Kakinuma

Publikováno v: Journal of Medicinal Chemistry. 65:14599-14613

20-Hydroxyeicosatetraenoic acid (20-HETE) is one of the major oxidized arachidonic acid (AA) metabolites produced by cytochrome P450 (CYP) 4A11 and CYP4F2 isozymes in the human liver and kidney. Numerous studies have suggested the involvement of 20-H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d86e880078af477f959a903c5a9ea20
https://doi.org/10.1021/acs.jmedchem.2c01089

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Akademický článek

In vitro characterization of luseogliflozin, a potent and competitive sodium glucose co-transporter 2 inhibitor: Inhibition kinetics and binding studies

Autor: Saeko Uchida, Akiko Mitani, Emi Gunji, Teisuke Takahashi, Koji Yamamoto

Publikováno v: Journal of Pharmacological Sciences, Vol 128, Iss 1, Pp 54-57 (2015)

In this study, we evaluated an inhibition model of luseogliflozin on sodium glucose co-transporter 2 (SGLT2). We also analyzed the binding kinetics of the drug to SGLT2 protein using [3H]-luseogliflozin. Luseogliflozin competitively inhibited human S

Externí odkaz: https://doaj.org/article/ea9b9314ba744633ae9a41d20382ac46

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Lead identification of novel tetrahydroimidazo[1,2-a]pyridine-5-carboxylic acid derivative as a potent heparanase-1 inhibitor

Autor: Yudai, Imai, Daisuke, Wakasugi, Ryo, Suzuki, Sota, Kato, Mami, Sugisaki, Masashi, Mima, Hiroh, Miyagawa, Mayumi, Endo, Natsuko, Fujimoto, Takuya, Fukunaga, Sayaka, Kato, Shoichi, Kuroda, Teisuke, Takahashi, Hiroyuki, Kakinuma

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 79:129050

Heparanase-1 (HPSE1) is an endo-β-d-glucuronidase that cleaves heparan sulfate proteoglycans into short-chain heparan sulfates (HS). The inhibition of HPSE1 has therapeutic potential for proteinuric diseases such as nephrotic syndrome because increa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1989640235cab9d4f57fea5d757fd63
https://doi.org/10.1016/j.bmcl.2022.129050

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DMOG, a Prolyl Hydroxylase Inhibitor, Increases Hemoglobin Levels without Exacerbating Hypertension and Renal Injury in Salt-Sensitive Hypertensive Rats

Autor: Teisuke Takahashi, Richard J. Roman, Sota Kato, Noriyuki Miyata

Publikováno v: J Pharmacol Exp Ther

Prolyl hydroxylase (PHD) inhibitors are being developed as alternatives to recombinant human erythropoietin (rHuEPO) for the treatment of anemia in patients with chronic kidney disease (CKD). However, the effects of PHD inhibitors and rHuEPO on blood

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1698f49f6256a2a8f699eae70fcbb868
https://doi.org/10.1124/jpet.119.262782

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TP0463518 (TS-143) Ameliorates Peptidoglycan-Polysaccharide Induced Anemia of Inflammation in Rats

Autor: Koji Yamamoto, Saeko Uchida, Sota Kato, Teisuke Takahashi

Publikováno v: Biologicalpharmaceutical bulletin. 44(11)

TP0463518 (TS-143) is a competitive prolyl hydroxylase 1/2/3 pan-inhibitor, and has been shown to specifically stabilize hypoxia-inducible factor-2 alpha in the liver to increase erythropoietin production. While TP0463518 has been shown to improve re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::187878d5fc51c8558a6f77e1a966a00d
https://pubmed.ncbi.nlm.nih.gov/34719642

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Design, synthesis and biological evaluation of novel 1H-pyrazole-4-carbonyl-4,5,6,7-tetrahydrobenzo [b]thiophene derivatives as gut-selective NaPi2b inhibitors

Autor: Yasunobu Ushiki, Kenichi Kawabe, Kumiko Yamamoto-Okada, Fumito Uneuchi, Yuta Asanuma, Chitose Yamaguchi, Hiroshi Ohta, Tsuyoshi Shibata, Tomohiro Abe, Lisa Okumura-Kitajima, Yuki Kosai, Mayumi Endo, Katsumasa Otake, Eiji Munetomo, Teisuke Takahashi, Hiroyuki Kakinuma

Publikováno v: Bioorganicmedicinal chemistry letters. 59

Intestinal sodium-dependent phosphate transport protein 2b (SLC34A2, NaPi2b) inhibitors are expected to be potential new candidates for anti-hyperphosphatemia drugs. However, a risk of on-target side effects based on the inhibition of NaPi2b in the l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60a0b1288f54af8bcf75b3a07f0e21c4
https://pubmed.ncbi.nlm.nih.gov/35066140

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Design, synthesis and biological evaluation of novel indole derivatives as gut-selective NaPi2b inhibitors

Autor: Yasunobu, Ushiki, Kenichi, Kawabe, Kumiko, Yamamoto-Okada, Fumito, Uneuchi, Yuta, Asanuma, Chitose, Yamaguchi, Hiroshi, Ohta, Tsuyoshi, Shibata, Tomohiro, Abe, Lisa, Okumura-Kitajima, Yuki, Kosai, Mayumi, Endo, Katsumasa, Otake, Eiji, Munetomo, Teisuke, Takahashi, Hiroyuki, Kakinuma

Publikováno v: Bioorganic & Medicinal Chemistry. 66:116783

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feb4cd0896c30a607f0687d651be2291
https://doi.org/10.1016/j.bmc.2022.116783

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Design, synthesis and biological evaluation of novel pyridine derivatives as gut-selective NaPi2b inhibitors

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 65:128700

We previously reported thiophene derivatives as gut-selective (minimally systemic) and potent sodium-dependent phosphate transport protein 2b (SLC34A2, NaPi2b) inhibitors. However, these derivatives did not suppress phosphate absorption form the inte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::042ae16f3d6bd5911bf0834ec8fa3dd9
https://doi.org/10.1016/j.bmcl.2022.128700

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