Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Teiko Komatsu"'
Publikováno v:
Drug Metabolism and Pharmacokinetics. 11:463-480
In order to clarify the metabolic fate of MCI-186 in rats, blood and plasma levels, distribution, metabolism and excretion were investigated after a single intravenous administration of 14C-MCI-186 to male and female rats. 1) After intravenous admini
Publikováno v:
Drug Metabolism and Pharmacokinetics. 11:481-491
During and after a single or repeated intravenous administration of 14C-MCI-186 (2 mg/kg/day) for 7, 14 and 21 days to male rats, blood and plasma levels, distribution, metabolism, excretion and accumulation of MCI-186 were investigated. 1) Tissue le
Publikováno v:
Drug Metabolism and Pharmacokinetics. 11:492-498
Publikováno v:
Drug Metabolism and Pharmacokinetics. 11:499-504
Autor:
Yasuhiro Morinaka, Kazutoshi Watanabe, Yasuo Takamatsu, Teiko Komatsu, Masaki Shinoda, Hiroshi Nakai, Seiu Iida
Publikováno v:
Drug Metabolism and Pharmacokinetics. 11:451-462
In order to clalify the species difference in metabolism of MCI-186, the identification of metabolites, urinary excretion rates of unchanged MCI-186 and its metabolites, and in vitro metabolism were investigated in rats, dogs and human. 1. Main metab
Publikováno v:
Pharmacology Biochemistry and Behavior. 51:935-939
The effects of MCI-225 on amnesia, the cerebral glucose metabolism, and choline acetyltransferase (ChAT) activity in basal forebrain (BF)-lesioned rats were studied in comparison with those of tacrine. Bilateral BF lesions with ibotenic acid impaired
Publikováno v:
Drug Metabolism and Pharmacokinetics. 6:377-398
The absorption, metabolism and excretion of MCI-9042 were investigated in male and female dogs after oral (20mg/kg) or intravenous (1 mg/kg) administration of 14C-MCI-9042.1. After oral administration of 14C-MCI-9042 to male and female dogs, both the
Publikováno v:
Drug Metabolism and Pharmacokinetics. 6:415-423
Publikováno v:
Drug Metabolism and Pharmacokinetics. 6:353-375
Publikováno v:
Drug Metabolism and Pharmacokinetics. 6:399-414
The absorption, distribution, metabolism, excretion and accumulation of MCI-9042 were investigated after repeated oral administration of 14C-MCI-9042 (20mg/kg/day) to male rats for 21 days. The effect of MCI-9042 on the hepatic drug-metabolizing enzy