Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Teikichi Ikura"'
Autor:
Hikari Tanaka, Kanoh Kondo, Kyota Fujita, Hidenori Homma, Kazuhiko Tagawa, Xiaocen Jin, Meihua Jin, Yuki Yoshioka, Sumire Takayama, Hitomi Masuda, Rie Tokuyama, Yukoh Nakazaki, Takashi Saito, Takaomi Saido, Shigeo Murayama, Teikichi Ikura, Nobutoshi Ito, Yu Yamamori, Kentaro Tomii, Marco E. Bianchi, Hitoshi Okazawa
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-23 (2021)
Tanaka et al use phosphoproteome analysis of post-mortem Alzheimer’s Disease (AD) brains and identified abnormal phosphorylation of Ku70, which leads to DNA damage and transcriptional repression-induced atypical cell death. In a mouse model of AD,
Externí odkaz:
https://doaj.org/article/fd80c0c5e83d4543afa38997ad8b886c
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Protein crystals are generally fragile and sensitive to subtle changes such as pH, ionic strength, and/or temperature in their crystallization mother liquor. Here, using T4 phage lysozyme as a model protein, the three-dimensional rigidification of pr
Externí odkaz:
https://doaj.org/article/3bea86c3731d41ef9f32ada0c29561fa
Publikováno v:
Biophysics and Physicobiology, Vol 16 (2019)
Pin1 is a peptidyl-prolyl isomerase (PPIase) which catalyzes cis/trans isomerization of pS/pT-P bond. Its activity is related to various cellular functions including suppression of Alzheimer’s disease. A cysteine residue C113 is known to be importa
Externí odkaz:
https://doaj.org/article/3d6afd0ebb884ab7acd24a4c67ce5ad1
Autor:
Isao Kii, Yuto Sumida, Toshiyasu Goto, Rie Sonamoto, Yukiko Okuno, Suguru Yoshida, Tomoe Kato-Sumida, Yuka Koike, Minako Abe, Yosuke Nonaka, Teikichi Ikura, Nobutoshi Ito, Hiroshi Shibuya, Takamitsu Hosoya, Masatoshi Hagiwara
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Kinase inhibitors are important drugs and usually target the ATP binding pocket of kinases. Here, Kii et al.report a completely new type of kinase inhibitor that specifically targets the protein folding intermediate state, but not the mature form, of
Externí odkaz:
https://doaj.org/article/cc58fcf33b4145468837fef116260032
Autor:
Hiroyuki Masuno, Teikichi Ikura, Daisuke Morizono, Isamu Orita, Sachiko Yamada, Masato Shimizu, Nobutoshi Ito
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 8, Pp 2206-2213 (2013)
The secondary bile acid lithocholic acid (LCA) and its derivatives act as selective modulators of the vitamin D receptor (VDR), although their structures fundamentally differ from that of the natural hormone 1α,25-dihydroxyvitamin D3 [1,25(OH)2D3)].
Externí odkaz:
https://doaj.org/article/1b4f265830f348b5abd8c0698dd12d27
Autor:
Kunitake Higo, Teikichi Ikura, Masayuki Oda, Hisayuki Morii, Jun Takahashi, Ryo Abe, Nobutoshi Ito
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e74482 (2013)
Src homology 2 (SH2) domains play a critical role in cellular signal transduction. They bind to peptides containing phosphotyrosine (pY) with various specificities that depend on the flanking amino-acid residues. The SH2 domain of growth-factor recep
Externí odkaz:
https://doaj.org/article/80d8e7e84a41461aa9a0f8041fbc5118
Publikováno v:
The Protein Journal. 41:71-78
Protein structures fluctuate in solution; therefore, proteins have multiple stable structures that are slightly different from each other. In this study, we determined the crystal structure of hen egg lysozyme refolded after denaturation at acidic pH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73ab2ef2984ef43609fe54ae34638b78
https://doi.org/10.1007/s10930-021-10036-3
https://doi.org/10.1007/s10930-021-10036-3
Autor:
Su Liu, Kanoh Kondo, Hidenori Homma, Yuki Yoshioka, Kyota Fujita, Hikari Tanaka, Nobutoshi Ito, Kazuhiko Tagawa, Yong Huang, Ryosuke Kawasaki, Sumire Takayama, Shin-ichi Tate, Hitoshi Okazawa, Teikichi Ikura
Publikováno v:
ACS Chemical Neuroscience. 12:3015-3027
Tau aggregation is a central hallmark of tauopathies such as frontotemporal lobar degeneration and progressive supranuclear palsy as well as of Alzheimer's disease, and it has been a target for therapeutic development. Herein, we unexpectedly found t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50b5a91480742602be27aa390c4b69e2
https://doi.org/10.1021/acschemneuro.1c00164
https://doi.org/10.1021/acschemneuro.1c00164
Autor:
Hisashi Okumura, Teikichi Ikura, Takuya Mizukami, Kosuke Maki, Kunio Ihara, Saho Segawa, Satoru G. Itoh, Heinrich Roder, Shunta Furuzawa
Publikováno v:
Proc Natl Acad Sci U S A
Protein conformational changes associated with ligand binding, especially those involving intrinsically disordered proteins, are mediated by tightly coupled intra- and intermolecular events. Such reactions are often discussed in terms of two limiting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e383a4d4f996375abf72b3868698772c
https://doi.org/10.1073/pnas.1914349117
https://doi.org/10.1073/pnas.1914349117
Autor:
Hitomi Masuda, Teikichi Ikura, Kanoh Kondo, Meihua Jin, Yuki Yoshioka, Hitoshi Okazawa, Yu Yamamori, Shigeo Murayama, Kyota Fujita, Marco E. Bianchi, Sumire Takayama, Yukoh Nakazaki, Rie Tokuyama, Xiaocen Jin, Hidenori Homma, Hikari Tanaka, Kentaro Tomii, Nobutoshi Ito, Kazuhiko Tagawa, Takaomi C. Saido, Takashi Saito
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-23 (2021)
Communications Biology
Communications Biology
DNA damage is increased in Alzheimer’s disease (AD), while the underlying mechanisms are unknown. Here, we employ comprehensive phosphoproteome analysis, and identify abnormal phosphorylation of 70 kDa subunit of Ku antigen (Ku70) at Ser77/78, whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38384ebec7a2fabd5ceda2a7654d1cc5
https://doi.org/10.1038/s42003-021-02671-4
https://doi.org/10.1038/s42003-021-02671-4