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An analysis of RNA quality metrics in human brain tissue.

Autor: Tian J; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY, USA., Lam TG; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY, USA., Ross SK; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY, USA., Ciener B; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY, USA., Leskinen S; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY, USA., Sivakumar S; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY, USA., Bennett DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, II, USA., Menon V; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY, USA.; Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA., McKhann GM; Department of Neurosurgery, Columbia University Irving Medical Center, New York, NY, USA., Runnels A; New York Genome Center, New York, NY, USA., Teich AF; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY, USA.; Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Oct 17. Date of Electronic Publication: 2024 Oct 17.

A cross-disease resource of living human microglia identifies disease-enriched subsets and tool compounds recapitulating microglial states.

Autor: Tuddenham JF; Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA.; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA.; Medical Scientist Training Program, Columbia University Irving Medical Center, New York, NY, USA., Taga M; Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY, USA., Haage V; Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA., Marshe VS; Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA., Roostaei T; Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA., White C; Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA., Lee AJ; Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA., Fujita M; Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA., Khairallah A; Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA., Zhang Y; Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA., Green G; Edmond & Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel., Hyman B; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Frosch M; Neuropathology Service, C.S. Kubik Laboratory for Neuropathology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA., Hopp S; Department of Pharmacology, UT Health San Antonio, San Antonio, TX, USA.; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, UT Health San Antonio, San Antonio, TX, USA., Beach TG; Banner Sun Health Research Institute, Sun City, AZ, USA., Serrano GE; Banner Sun Health Research Institute, Sun City, AZ, USA., Corboy J; Department of Neurology, University of Colorado, and Rocky Mountain Multiple Sclerosis Center at the University of Colorado, Aurora, CO, USA., Habib N; Edmond & Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel., Klein HU; Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY, USA., Soni RK; Proteomics and Macromolecular Crystallography Shared Resource, Herbert Irving Comprehensive Cancer Center, New York, NY, USA., Teich AF; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY, USA.; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.; Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA., Hickman RA; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Alcalay RN; Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA.; Movement Disorders Division, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel., Shneider N; Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA.; Eleanor and Lou Gehrig ALS Center, Columbia University Medical Center, New York, NY, USA., Schneider J; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA., Sims PA; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA.; Department of Biochemistry and Molecular Biophysics, Columbia University Irving Medical Center, New York, NY, USA., Bennett DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA., Olah M; Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA., Menon V; Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA., De Jager PL; Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA. pld2115@cumc.columbia.edu.

Publikováno v: Nature neuroscience [Nat Neurosci] 2024 Oct 15. Date of Electronic Publication: 2024 Oct 15.

Alzheimer's disease CSF biomarkers correlate with early pathology and alterations in neuronal and glial gene expression.

Autor: Ropri AS; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York, USA.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, New York, USA., Lam TG; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York, USA.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, New York, USA., Kalia V; Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York, USA., Buchanan HM; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York, USA.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, New York, USA., Bartosch AMW; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York, USA.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, New York, USA., Youth EHH; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York, USA.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, New York, USA., Xiao H; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York, USA.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, New York, USA., Ross SK; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York, USA.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, New York, USA., Jain A; Quantitative Proteomics and Metabolomics Center, Department of Biological Sciences, Columbia University, New York, New York, USA., Chakrabarty JK; Quantitative Proteomics and Metabolomics Center, Department of Biological Sciences, Columbia University, New York, New York, USA., Kang MS; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, New York, USA.; Department of Neurology, Columbia University Irving Medical Center, New York, New York, USA., Boyett D; Department of Neurosurgery, Columbia University Irving Medical Center, New York, New York, USA., Spinazzi EF; Department of Neurosurgery, Columbia University Irving Medical Center, New York, New York, USA., Iodice G; Ankyra Therapeutics, Cambridge, Massachusetts, USA., McGovern RA; Department of Neurosurgery, University of Minnesota, Minneapolis, Minnesota, USA., Honig LS; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, New York, USA.; Department of Neurology, Columbia University Irving Medical Center, New York, New York, USA., Brown LM; Quantitative Proteomics and Metabolomics Center, Department of Biological Sciences, Columbia University, New York, New York, USA., Miller GW; Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York, USA., McKhann GM; Department of Neurosurgery, Columbia University Irving Medical Center, New York, New York, USA., Teich AF; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York, USA.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, New York, USA.; Department of Neurology, Columbia University Irving Medical Center, New York, New York, USA.

Publikováno v: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2024 Oct; Vol. 20 (10), pp. 7090-7103. Date of Electronic Publication: 2024 Aug 27.

ABCA7-dependent induction of neuropeptide Y is required for synaptic resilience in Alzheimer's disease through BDNF/NGFR signaling.

Autor: Tayran H; The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, Columbia University, New York, NY 10032, USA; Department of Neurology, Columbia University Irving Medical Center, Columbia University, New York, NY 10032, USA., Yilmaz E; The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, Columbia University, New York, NY 10032, USA; Department of Neurology, Columbia University Irving Medical Center, Columbia University, New York, NY 10032, USA., Bhattarai P; The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, Columbia University, New York, NY 10032, USA; Department of Neurology, Columbia University Irving Medical Center, Columbia University, New York, NY 10032, USA., Min Y; Department of Neuroscience, Mayo Clinic Florida, Jacksonville, FL 32224, USA., Wang X; Department of Quantitative Health Sciences, Mayo Clinic Florida, Jacksonville, FL 32224, USA., Ma Y; Department of Neurology, Columbia University Irving Medical Center, Columbia University, New York, NY 10032, USA., Wang N; Department of Neuroscience, Mayo Clinic Florida, Jacksonville, FL 32224, USA., Jeong I; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway., Nelson N; The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, Columbia University, New York, NY 10032, USA; Department of Neurology, Columbia University Irving Medical Center, Columbia University, New York, NY 10032, USA., Kassara N; The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, Columbia University, New York, NY 10032, USA., Cosacak MI; German Center for Neurodegenerative Diseases (DZNE), Tatzberg 41, 01307 Dresden, Germany., Dogru RM; The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, Columbia University, New York, NY 10032, USA., Reyes-Dumeyer D; The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, Columbia University, New York, NY 10032, USA; Department of Neurology, Columbia University Irving Medical Center, Columbia University, New York, NY 10032, USA; The Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University Irving Medical Center, Columbia University, 630 West 168th Street, New York, NY 10032, USA., Stenersen JM; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway., Reddy JS; Department of Neuroscience, Mayo Clinic Florida, Jacksonville, FL 32224, USA., Qiao M; The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, Columbia University, New York, NY 10032, USA; Department of Neurology, Columbia University Irving Medical Center, Columbia University, New York, NY 10032, USA; The Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University Irving Medical Center, Columbia University, 630 West 168th Street, New York, NY 10032, USA., Flaherty D; The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, Columbia University, New York, NY 10032, USA; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, Columbia University, New York, NY 10032, USA., Gunasekaran TI; The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, Columbia University, New York, NY 10032, USA; Department of Neurology, Columbia University Irving Medical Center, Columbia University, New York, NY 10032, USA; The Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University Irving Medical Center, Columbia University, 630 West 168th Street, New York, NY 10032, USA., Yang Z; The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, Columbia University, New York, NY 10032, USA; Department of Neurology, Columbia University Irving Medical Center, Columbia University, New York, NY 10032, USA; The Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University Irving Medical Center, Columbia University, 630 West 168th Street, New York, NY 10032, USA., Jurisch-Yaksi N; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway., Teich AF; The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, Columbia University, New York, NY 10032, USA; Department of Neurology, Columbia University Irving Medical Center, Columbia University, New York, NY 10032, USA; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, Columbia University, New York, NY 10032, USA., Kanekiyo T; Department of Neuroscience, Mayo Clinic Florida, Jacksonville, FL 32224, USA; Center for Regenerative Biotherapeutics, Mayo Clinic, Jacksonville, FL 32224, USA., Tosto G; The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, Columbia University, New York, NY 10032, USA; Department of Neurology, Columbia University Irving Medical Center, Columbia University, New York, NY 10032, USA; The Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University Irving Medical Center, Columbia University, 630 West 168th Street, New York, NY 10032, USA., Vardarajan BN; The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, Columbia University, New York, NY 10032, USA; Department of Neurology, Columbia University Irving Medical Center, Columbia University, New York, NY 10032, USA; The Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University Irving Medical Center, Columbia University, 630 West 168th Street, New York, NY 10032, USA., İş Ö; Department of Neuroscience, Mayo Clinic Florida, Jacksonville, FL 32224, USA., Ertekin-Taner N; Department of Neuroscience, Mayo Clinic Florida, Jacksonville, FL 32224, USA; Department of Neurology, Mayo Clinic Florida, Jacksonville, FL 32224, USA., Mayeux R; The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, Columbia University, New York, NY 10032, USA; Department of Neurology, Columbia University Irving Medical Center, Columbia University, New York, NY 10032, USA; The Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University Irving Medical Center, Columbia University, 630 West 168th Street, New York, NY 10032, USA; Department of Psychiatry, College of Physicians and Surgeons, Columbia University Irving Medical Center, Columbia University, 1051 Riverside Drive, New York, NY 10032, USA; Department of Epidemiology, Mailman School of Public Health, Columbia University Irving Medical Center, Columbia University, 722 W. 168th St., New York, NY 10032, USA., Kizil C; The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, Columbia University, New York, NY 10032, USA; Department of Neurology, Columbia University Irving Medical Center, Columbia University, New York, NY 10032, USA; The Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University Irving Medical Center, Columbia University, 630 West 168th Street, New York, NY 10032, USA. Electronic address: ck2893@cumc.columbia.edu.

Publikováno v: Cell genomics [Cell Genom] 2024 Sep 11; Vol. 4 (9), pp. 100642. Date of Electronic Publication: 2024 Aug 30.