Brain Targeting Nanomedicines: Pitfalls and Promise

Autor: Kakinen A, Jiang Y, Davis TP, Teesalu T, Saarma M

Publikováno v: International Journal of Nanomedicine, Vol Volume 19, Pp 4857-4875 (2024)

Aleksandr Kakinen,1,2 Yuhao Jiang,2 Thomas Paul Davis,2 Tambet Teesalu,3,4 Mart Saarma1 1Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland; 2Australian Institute for Bioengineering and Nanotechnology, University of Queensl

Externí odkaz: https://doaj.org/article/f9e5395d26be48b996bd77b06e1eb371

A Cyclic Peptide Targets Glioblastoma by Binding to Aberrantly Exposed SNAP25.

Autor: Arias AG; Medical Physics Department, Gerencia de Área Aplicaciones Nucleares a la Salud (GAANS)Centro Atómico Bariloche, Avenida Bustillo 9500, San Carlos de Bariloche R8402AGP, Argentina., Tovar-Martinez L; Institute for Advanced Chemistry of Catalonia, IQAC-CSIC, Jordi Girona 18-26, Barcelona 08034, Spain.; Doctorate in Biotechnology, Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona, Avda. Diagonal 643, 08028 Barcelona, Spain., Asciutto EK; School of Science and Technology, National University of San Martin (UNSAM) and CONICET, Campus Migueletes, 25 de Mayo y Francia, San Martín 1650, Argentina., Mann A; Aivocode, Biolabs San Diego, 9276 Scranton Rd., San Diego, California 92121, United States., Põšnograjeva K; Laboratory of Precision and Nanomedicine, Institute of Biomedicine and Translational Medicine, University of Tartu, Ravila 14b, Tartu 50411, Estonia., Gracia LS; Laboratory of Precision and Nanomedicine, Institute of Biomedicine and Translational Medicine, University of Tartu, Ravila 14b, Tartu 50411, Estonia., Royo M; Institute for Advanced Chemistry of Catalonia, IQAC-CSIC, Jordi Girona 18-26, Barcelona 08034, Spain.; Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine, CIBER-BBN, Jordi Girona 18-26, 08034 Barcelona, Spain., Haugas M; Laboratory of Precision and Nanomedicine, Institute of Biomedicine and Translational Medicine, University of Tartu, Ravila 14b, Tartu 50411, Estonia., Teesalu T; Laboratory of Precision and Nanomedicine, Institute of Biomedicine and Translational Medicine, University of Tartu, Ravila 14b, Tartu 50411, Estonia., Smulski C; Medical Physics Department, Gerencia de Área Aplicaciones Nucleares a la Salud (GAANS)Centro Atómico Bariloche, Avenida Bustillo 9500, San Carlos de Bariloche R8402AGP, Argentina., Ruoslahti E; Sanford Burnham Prebys Medical Discovery Institute, 10901 N. Torrey Pines Rd, La Jolla, California 92037, United States., Scodeller P; Laboratory of Precision and Nanomedicine, Institute of Biomedicine and Translational Medicine, University of Tartu, Ravila 14b, Tartu 50411, Estonia.; Institute for Advanced Chemistry of Catalonia, IQAC-CSIC, Jordi Girona 18-26, Barcelona 08034, Spain.

Publikováno v: Molecular pharmaceutics [Mol Pharm] 2024 Nov 22. Date of Electronic Publication: 2024 Nov 22.

PL3 CendR peptide shows specific uptake in cultured Y79 retinoblastoma cells with nucleolar accumulation.

Autor: Korhonen S; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Yliopistonranta 1 C, Kuopio 70210, Finland. Electronic address: sonja.korhonen@uef.fi., Bosch S; Institute of Biomedicine, University of Eastern Finland, Yliopistonranta 8, Kuopio 70211, Finland., Erkinheimo A; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Yliopistonranta 1 C, Kuopio 70210, Finland., Lajunen T; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Yliopistonranta 1 C, Kuopio 70210, Finland; Drug Research Program, Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, Viikinkaari 5 E, Helsinki FI-00790, Finland., Rilla K; Institute of Biomedicine, University of Eastern Finland, Yliopistonranta 8, Kuopio 70211, Finland., Teesalu T; Laboratory of Precision and Nanomedicine, Institute of Biomedicine and Translational Medicine, University of Tartu, Ravila 14b, Tartu 50411, Estonia; Materials Research Laboratory, University of California Santa Barbara, Santa Barbara 93106, USA., Subrizi A; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Yliopistonranta 1 C, Kuopio 70210, Finland., Ruponen M; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Yliopistonranta 1 C, Kuopio 70210, Finland., Urtti A; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Yliopistonranta 1 C, Kuopio 70210, Finland; Drug Research Program, Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, Viikinkaari 5 E, Helsinki FI-00790, Finland., Reinisalo M; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Yliopistonranta 1 C, Kuopio 70210, Finland.

Publikováno v: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences [Eur J Pharm Sci] 2024 Oct 01; Vol. 201, pp. 106866. Date of Electronic Publication: 2024 Jul 25.

Mechanisms and Barriers in Nanomedicine: Progress in the Field and Future Directions.

Autor: Anchordoquy T; Department of Pharmaceutical Sciences, The Skaggs School of Pharmacy and Pharmaceutical Sciences, the University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045, United States., Artzi N; Brigham and Woman's Hospital, Department of Medicine, Division of Engineering in Medicine, Harvard Medical School, Boston, Massachusetts 02215, United States.; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02215, United States.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts 02215, United States., Balyasnikova IV; Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University; Northwestern Medicine Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, United States., Barenholz Y; Membrane and Liposome Research Lab, IMRIC, Hebrew University Hadassah Medical School, Jerusalem 9112102, Israel., La-Beck NM; Department of Immunotherapeutics and Biotechnology, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Abilene, Texas 79601, United States., Brenner JS; Departments of Medicine and Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States., Chan WCW; Institute of Biomedical Engineering, University of Toronto, Rosebrugh Building, 164 College Street, Toronto, Ontario M5S 3G9, Canada.; Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada., Decuzzi P; Laboratory of Nanotechnology for Precision Medicine, Italian Institute of Technology, 16163 Genova, Italy., Exner AA; Departments of Radiology and Biomedical Engineering, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, United States., Gabizon A; The Helmsley Cancer Center, Shaare Zedek Medical Center and The Hebrew University of Jerusalem-Faculty of Medicine, Jerusalem, 9103102, Israel., Godin B; Department of Nanomedicine, Houston Methodist Research Institute, Houston, Texas 77030, United States.; Department of Obstetrics and Gynecology, Houston Methodist Hospital, Houston, Texas 77030, United States.; Department of Obstetrics and Gynecology, Weill Cornell Medicine College (WCMC), New York, New York 10065, United States.; Department of Biomedical Engineering, Texas A&M, College Station, Texas 7784,3 United States., Lai SK; Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina 27599, United States., Lammers T; Department of Nanomedicine and Theranostics, Institute for Experimental Molecular Imaging, Center for Biohybrid Medical Systems, University Hospital RWTH Aachen, 52074 Aachen, Germany., Mitchell MJ; Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.; Penn Institute for RNA Innovation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States., Moghimi SM; School of Pharmacy, Newcastle University, Newcastle upon Tyne NE1 7RU, U.K.; Translational and Clinical Research Institute, Faculty of Health and Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, U.K.; Colorado Center for Nanomedicine and Nanosafety, University of Colorado Anschutz Medical Center, Aurora, Colorado 80045, United States., Muzykantov VR; Department of Systems Pharmacology and Translational Therapeutics, The Perelman School of Medicine, The University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States., Peer D; Laboratory of Precision Nanomedicine, Shmunis School of Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, 69978, Israel.; Department of Materials Sciences and Engineering, Iby and Aladar Fleischman Faculty of Engineering, Tel Aviv University, Tel Aviv, 69978, Israel.; Center for Nanoscience and Nanotechnology, Tel Aviv University, Tel Aviv, 69978, Israel.; Cancer Biology Research Center, Tel Aviv University, Tel Aviv, 69978, Israel., Nguyen J; Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina 27599, United States., Popovtzer R; Faculty of Engineering and the Institute of Nanotechnology & Advanced Materials, Bar-Ilan University, 5290002 Ramat Gan, Israel., Ricco M; Department of Pharmaceutical Sciences, The Skaggs School of Pharmacy and Pharmaceutical Sciences, the University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045, United States., Serkova NJ; Department of Radiology, University of Colorado Cancer Center, Anschutz Medical Campus, Aurora, Colorado 80045, United States., Singh R; Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27101, United States.; Atrium Health Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, North Carolina 27101, United States., Schroeder A; Department of Chemical Engineering, Technion, Israel Institute of Technology, Haifa 32000, Israel., Schwendeman AA; Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48108; Biointerfaces Institute, University of Michigan, Ann Arbor, Michigan 48108, United States., Straehla JP; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts 02115 United States.; Koch Institute for Integrative Cancer Research at MIT, Cambridge Massachusetts 02139 United States., Teesalu T; Laboratory of Precision and Nanomedicine, Institute of Biomedicine and Translational Medicine, University of Tartu, 50411 Tartu, Estonia., Tilden S; Department of Pharmaceutical Sciences, The Skaggs School of Pharmacy and Pharmaceutical Sciences, the University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045, United States., Simberg D; Department of Pharmaceutical Sciences, The Skaggs School of Pharmacy and Pharmaceutical Sciences, the University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045, United States.

Publikováno v: ACS nano [ACS Nano] 2024 Jun 04; Vol. 18 (22), pp. 13983-13999. Date of Electronic Publication: 2024 May 20.

New Tools for Streamlined In Vivo Homing Peptide Identification.

Autor: Põšnograjeva K; Laboratory of Precision and Nanomedicine, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia., Pleiko K; Laboratory of Precision and Nanomedicine, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.; Faculty of Medicine, University of Latvia, Riga, Latvia., Haugas M; Laboratory of Precision and Nanomedicine, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia., Teesalu T; Laboratory of Precision and Nanomedicine, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia. tambet.teesalu@ut.ee.; Cancer Research Center, Sanford-Burnham-Prebys Medical Discovery Institute, La Jolla, CA, USA. tambet.teesalu@ut.ee.; Center for Nanomedicine and Department of Cell, Molecular and Developmental Biology, University of California, Santa Barbara, CA, USA. tambet.teesalu@ut.ee.

Publikováno v: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2022; Vol. 2383, pp. 385-412.