RNase H1 promotes replication fork progression through oppositely transcribed regions of Drosophila mitochondrial DNA

Autor: Gonzalez de Cozar, Jose M., Gerards, Mike, Teeri, Eveliina, George, Jack, Dufour, Eric, Jacobs, Howard T., Joers, Priit

Publikováno v: Journal of Biological Chemistry, 294(12), 4331-4344. American Society for Biochemistry and Molecular Biology, Inc.

Mitochondrial DNA (mtDNA) replication uses a simple core machinery similar to those of bacterial viruses and plasmids, but its components are challenging to unravel. Here, we found that, as in mammals, the single Drosophila gene for RNase H1 (rnh1) h

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RNase H1 promotes replication fork progression through oppositely transcribed regions of Drosophila mitochondrial DNA.

Autor: González de Cózar JM; From the Faculty of Medicine and Health Technology and Tampere University Hospital, FI-33014 Tampere University, Finland., Gerards M; From the Faculty of Medicine and Health Technology and Tampere University Hospital, FI-33014 Tampere University, Finland., Teeri E; From the Faculty of Medicine and Health Technology and Tampere University Hospital, FI-33014 Tampere University, Finland., George J; From the Faculty of Medicine and Health Technology and Tampere University Hospital, FI-33014 Tampere University, Finland., Dufour E; From the Faculty of Medicine and Health Technology and Tampere University Hospital, FI-33014 Tampere University, Finland., Jacobs HT; From the Faculty of Medicine and Health Technology and Tampere University Hospital, FI-33014 Tampere University, Finland, howard.jacobs@tuni.fi.; Institute of Biotechnology, FI-00014 University of Helsinki, Finland, and., Jõers P; From the Faculty of Medicine and Health Technology and Tampere University Hospital, FI-33014 Tampere University, Finland.; Institute of Molecular and Cell Biology, University of Tartu, Riia 23, 51010 Tartu, Estonia.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2019 Mar 22; Vol. 294 (12), pp. 4331-4344. Date of Electronic Publication: 2019 Jan 11.