Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Teemu P Miettinen"'
Publikováno v:
eLife, Vol 11 (2022)
Cell mass and composition change with cell cycle progression. Our previous work characterized buoyant mass dynamics in mitosis (Miettinen et al., 2019), but how dry mass and cell composition change in mitosis has remained unclear. To better understan
Externí odkaz:
https://doaj.org/article/740245627cab49fcaf3d54dc46fedddb
Autor:
Pascal D Odermatt, Teemu P Miettinen, Joël Lemière, Joon Ho Kang, Emrah Bostan, Scott R Manalis, Kerwyn Casey Huang, Fred Chang
Publikováno v:
eLife, Vol 10 (2021)
Intracellular density impacts the physical nature of the cytoplasm and can globally affect cellular processes, yet density regulation remains poorly understood. Here, using a new quantitative phase imaging method, we determined that dry-mass density
Externí odkaz:
https://doaj.org/article/805e3887740b465cacc02c0671d8b0d7
Publikováno v:
eLife, Vol 8 (2019)
The extent and dynamics of animal cell biomass accumulation during mitosis are unknown, primarily because growth has not been quantified with sufficient precision and temporal resolution. Using the suspended microchannel resonator and protein synthes
Externí odkaz:
https://doaj.org/article/92d8fb16dc4046adaef49556d3aa1756
Autor:
Benjamin R. K. Roller, Cathrine Hellerschmied, Yanqi Wu, Teemu P. Miettinen, Annika L. Gomez, Scott R. Manalis, Martin F. Polz
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT Optical density is a proxy of total biomass concentration and is commonly used for measuring the growth of bacterial cultures. However, there is a misconception that exponential optical density growth is equivalent to steady-state population
Externí odkaz:
https://doaj.org/article/e1f73d00d0004d3f84893f14f7095ebe
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Ribosome kinetics are rate-limiting for protein synthesis. Here the authors evolve diverse 16S rRNAs for enhanced protein synthesis rates and genetic code expansion efficiencies in vivo.
Externí odkaz:
https://doaj.org/article/32003b95f3524e2ca3a03d553664173a
Autor:
Joon Ho Kang, Georgios Katsikis, Zhaoqi Li, Kiera M. Sapp, Max A. Stockslager, Daniel Lim, Matthew G. Vander Heiden, Michael B. Yaffe, Scott R. Manalis, Teemu P. Miettinen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
ATP drives most cellular processes, although ATP production and consumption levels during mitosis remain unreported. Here, the authors combine metabolic measurements and modeling to quantify ATP levels and synthesis dynamics, revealing that ATP synth
Externí odkaz:
https://doaj.org/article/7d36fb2261454301970a2d8ba6a0530b
Autor:
Frances F. Diehl, Teemu P. Miettinen, Ryan Elbashir, Christopher S. Nabel, Alicia M. Darnell, Brian T. Do, Scott R. Manalis, Caroline A. Lewis, Matthew G. Vander Heiden
Publikováno v:
Nature Cell Biology. 24:1252-1264
Nucleotide metabolism supports RNA synthesis and DNA replication to enable cell growth and division. Nucleotide depletion can inhibit cell growth and proliferation, but how cells sense and respond to changes in the relative levels of individual nucle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc0baccd3e159a763694db64c5aa4700
https://doi.org/10.1038/s41556-022-00965-1
https://doi.org/10.1038/s41556-022-00965-1
Autor:
Teemu P. Miettinen, Mikael Björklund
Publikováno v:
Cell Reports, Vol 13, Iss 11, Pp 2610-2620 (2015)
Balance between cell growth and proliferation determines cell size homeostasis, but little is known about how metabolic pathways are involved in the maintenance of this balance. Here, we perform a screen with a library of clinically used drug molecul
Externí odkaz:
https://doaj.org/article/610cad1fd68148c793b123bf2d4d45ad
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications
In bacteria, ribosome kinetics are considered rate-limiting for protein synthesis and cell growth. Enhanced ribosome kinetics may augment bacterial growth and biomanufacturing through improvements to overall protein yield, but whether this can be ach
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e53ccc7c2c6e738152c4bbcad8023540
https://doaj.org/article/32003b95f3524e2ca3a03d553664173a
https://doaj.org/article/32003b95f3524e2ca3a03d553664173a
Autor:
Margarete Diaz-Cuadros, Teemu P. Miettinen, Owen S. Skinner, Dylan Sheedy, Carlos Manlio Díaz-García, Svetlana Gapon, Alexis Hubaud, Gary Yellen, Scott R. Manalis, William M. Oldham, Olivier Pourquié
Publikováno v:
Nature. 616:E4-E4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf2f0570472e965a3d71918d3d2ea8db
https://doi.org/10.1038/s41586-023-05924-w
https://doi.org/10.1038/s41586-023-05924-w