Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Teemu Kivioja"'
Autor:
Kimmo Palin, Esa Pitkänen, Mikko Turunen, Biswajyoti Sahu, Päivi Pihlajamaa, Teemu Kivioja, Eevi Kaasinen, Niko Välimäki, Ulrika A. Hänninen, Tatiana Cajuso, Mervi Aavikko, Sari Tuupanen, Outi Kilpivaara, Linda van den Berg, Johanna Kondelin, Tomas Tanskanen, Riku Katainen, Marta Grau, Heli Rauanheimo, Roosa-Maria Plaketti, Aurora Taira, Päivi Sulo, Tuomo Hartonen, Kashyap Dave, Bernhard Schmierer, Sandeep Botla, Maria Sokolova, Anna Vähärautio, Kornelia Gladysz, Halit Ongen, Emmanouil Dermitzakis, Jesper Bertram Bramsen, Torben Falck Ørntoft, Claus Lindbjerg Andersen, Ari Ristimäki, Anna Lepistö, Laura Renkonen-Sinisalo, Jukka-Pekka Mecklin, Jussi Taipale, Lauri A. Aaltonen
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
In this study the authors examine the allelic imbalance (AI) landscape of colorectal cancer, reporting loss of TP53 as a driver of AI. They use CRISPR-Cas9 screens to identify 79 genes (within AI regions) regulating cell growth and identify a network
Externí odkaz:
https://doaj.org/article/0d1e862be9834942b8b1513c12b2e466
Autor:
Bernhard Schmierer, Sandeep K Botla, Jilin Zhang, Mikko Turunen, Teemu Kivioja, Jussi Taipale
Publikováno v:
Molecular Systems Biology, Vol 13, Iss 10, Pp 1-8 (2017)
Abstract Loss‐of‐function screening by CRISPR/Cas9 gene knockout with pooled, lentiviral guide libraries is a widely applicable method for systematic identification of genes contributing to diverse cellular phenotypes. Here, Random Sequence Label
Externí odkaz:
https://doaj.org/article/d1222f52f55b4103af3876b617c9edcf
Autor:
Mikko Turunen, Jason M. Spaeth, Salla Keskitalo, Min Ju Park, Teemu Kivioja, Alison D. Clark, Netta Mäkinen, Fangjian Gao, Kimmo Palin, Helka Nurkkala, Anna Vähärautio, Mervi Aavikko, Kati Kämpjärvi, Pia Vahteristo, Chongwoo A. Kim, Lauri A. Aaltonen, Markku Varjosalo, Jussi Taipale, Thomas G. Boyer
Publikováno v:
Cell Reports, Vol 7, Iss 3, Pp 654-660 (2014)
Somatic mutations in exon 2 of the RNA polymerase II transcriptional Mediator subunit MED12 occur at very high frequency (∼70%) in uterine leiomyomas. However, the influence of these mutations on Mediator function and the molecular basis for their
Externí odkaz:
https://doaj.org/article/59206a3393054e17a8c174a02fdf6b30
Autor:
Kazuhiro R Nitta, Arttu Jolma, Yimeng Yin, Ekaterina Morgunova, Teemu Kivioja, Junaid Akhtar, Korneel Hens, Jarkko Toivonen, Bart Deplancke, Eileen E M Furlong, Jussi Taipale
Publikováno v:
eLife, Vol 4 (2015)
Divergent morphology of species has largely been ascribed to genetic differences in the tissue-specific expression of proteins, which could be achieved by divergence in cis-regulatory elements or by altering the binding specificity of transcription f
Externí odkaz:
https://doaj.org/article/11fa20f60f5d445aa2130f64f79fb476
Autor:
Lauri A. Aaltonen, Jussi Taipale, Auli Karhu, Rainer Lehtonen, Diego Arango, Torben Orntoft, Heikki Järvinen, Jukka-Pekka Mecklin, Kyösti Nuorva, Sampsa Hautaniemi, Kari Nousiainen, Juha Saharinen, Virpi Launonen, Teemu Kivioja, Heli J. Lehtonen, Iina Niittymäki, Mia Biström, Sari Tuupanen, Mikko Turunen, Heli Sammalkorpi, Mikael Björklund, Pia Alhopuro
Supplementary Figures S1-S3 and Supplementary Tables S1-S3.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9b56a8a1ee8a99e34fff4bda299fe61
https://doi.org/10.1158/1541-7786.22518903.v1
https://doi.org/10.1158/1541-7786.22518903.v1
Autor:
Lauri A. Aaltonen, Jussi Taipale, Auli Karhu, Rainer Lehtonen, Diego Arango, Torben Orntoft, Heikki Järvinen, Jukka-Pekka Mecklin, Kyösti Nuorva, Sampsa Hautaniemi, Kari Nousiainen, Juha Saharinen, Virpi Launonen, Teemu Kivioja, Heli J. Lehtonen, Iina Niittymäki, Mia Biström, Sari Tuupanen, Mikko Turunen, Heli Sammalkorpi, Mikael Björklund, Pia Alhopuro
The circadian clock regulates daily variations in physiologic processes. CLOCK acts as a regulator in the circadian apparatus controlling the expression of other clock genes, including PER1. Clock genes have been implicated in cancer-related function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d5081e44f1390e7f3dd29c5b69e3068
https://doi.org/10.1158/1541-7786.c.6542175
https://doi.org/10.1158/1541-7786.c.6542175
Autor:
Otto Kauko, Mikko Turunen, Päivi Pihlajamaa, Antti Häkkinen, Rayner M. L. Queiroz, Mirva Pääkkönen, Sami Ventelä, Massimiliano Gaetani, Susanna Lundström, Antonio Murgia, Biswajyoti Sahu, Johannes Routila, Heikki Irjala, Julian L. Griffin, Kathryn S. Lilley, Teemu Kivioja, Sampsa Hautaniemi, Jussi Taipale
Mutations in hundreds of genes have been associated with formation of human cancer, with different oncogenic lesions prevalent in different cancer types. Yet, the malignant phenotype is simple, characterized by unrestricted growth of cells that invad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b40c7a52db36e705563718efdc482eb
https://doi.org/10.1101/2022.09.27.509636
https://doi.org/10.1101/2022.09.27.509636
The transcription factor Myc drives cell growth across animal phyla and is activated in most forms of human cancer. However, it is unclear which Myc target genes need to be regulated to induce growth and whether multiple targets act additively or if
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8367262816409e5acfec0899153b5e6e
http://hdl.handle.net/10138/352197
http://hdl.handle.net/10138/352197
Autor:
Biswajyoti Sahu, Tuomo Hartonen, Päivi Pihlajamaa, Bei Wei, Kashyap Dave, Fangjie Zhu, Eevi Kaasinen, Katja Lidschreiber, Michael Lidschreiber, Carsten O. Daub, Patrick Cramer, Teemu Kivioja, Jussi Taipale
Publikováno v:
Nature Genetics
Funder: Sigrid Juséliuksen Säätiö (Sigrid Jusélius Foundation); doi: https://doi.org/10.13039/501100006306
Funder: Jane ja Aatos Erkon Säätiö (Jane and Aatos Erkko Foundation); doi: https://doi.org/10.13039/501100004012
Funder: Syö
Funder: Jane ja Aatos Erkon Säätiö (Jane and Aatos Erkko Foundation); doi: https://doi.org/10.13039/501100004012
Funder: Syö
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a921b9355f20739b39b8d1b6f0a9a6f
MYC is an oncogenic transcription factor that controls major pathways promoting cell growth and proliferation. MYC has been implicated in the regulation of large number of genes, but the exact target genes responsible for its proliferative effects ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d93f722ea130ff4ce00b6ca0640093c8
https://doi.org/10.1101/2021.09.17.460746
https://doi.org/10.1101/2021.09.17.460746