Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Teemu Haikarainen"'
Publikováno v:
SLAS Discovery, Vol 28, Iss 4, Pp 180-187 (2023)
JAK2 transmits signals of several important cytokines, such as growth hormone and erythropoietin. The interest toward the therapeutic targeting of JAK2 was boosted in 2005, when the somatic JAK2 V617F mutation, responsible for the majority of myelopr
Externí odkaz:
https://doaj.org/article/1e1bca33a08c483781dffbd076c780d1
Autor:
Juha Saarikettu, Saara Lehmusvaara, Marko Pesu, Ilkka Junttila, Juha Partanen, Petra Sipilä, Matti Poutanen, Jie Yang, Teemu Haikarainen, Olli Silvennoinen
Publikováno v:
FASEB BioAdvances, Vol 5, Iss 5, Pp 183-198 (2023)
Abstract Snd1 is an evolutionarily conserved RNA‐binding protein implicated in several regulatory processes in gene expression including activation of transcription, mRNA splicing, and microRNA decay. Here, we have investigated the outcome of Snd1
Externí odkaz:
https://doaj.org/article/16f18b224da54a86aa8f9e82d02f1857
Autor:
Anniina T. Virtanen, Teemu Haikarainen, Parthasarathy Sampathkumar, Maaria Palmroth, Sanna Liukkonen, Jianping Liu, Natalia Nekhotiaeva, Stevan R. Hubbard, Olli Silvennoinen
Publikováno v:
Pharmaceuticals, Vol 16, Iss 1, p 75 (2023)
Hyperactive mutation V617F in the JAK2 regulatory pseudokinase domain (JH2) is prevalent in patients with myeloproliferative neoplasms. Here, we identified novel small molecules that target JH2 of JAK2 V617F and characterized binding via biochemical
Externí odkaz:
https://doaj.org/article/6cfdba99ff324992a07f46b8c564e944
Autor:
Teemu Haikarainen, Mariana Schlesinger, Ezeogo Obaji, Silvia H. Fernández Villamil, Lari Lehtiö
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Trypanosoma brucei is a unicellular parasite responsible for African trypanosomiasis or sleeping sickness. It contains a single PARP enzyme opposed to many higher eukaryotes, which have numerous PARPs. PARPs are responsible for a post-transl
Externí odkaz:
https://doaj.org/article/383567bfb60a4e1f9f36829cf9b4a8ca
Autor:
Teemu Haikarainen, Harikanth Venkannagari, Mohit Narwal, Ezeogo Obaji, Hao-Wei Lee, Yves Nkizinkiko, Lari Lehtiö
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65404 (2013)
Recently a novel inhibitor of Wnt signaling was discovered. The compound, WIKI4, was found to act through tankyrase inhibition and regulate β-catenin levels in many cancer cell lines and human embryonic stem cells. Here we confirm that WIKI4 is a hi
Externí odkaz:
https://doaj.org/article/d65d152848a14c07afbd50647aa37410
Autor:
Salomé C Vilchez Larrea, Teemu Haikarainen, Mohit Narwal, Mariana Schlesinger, Harikanth Venkannagari, Mirtha M Flawiá, Silvia H Fernández Villamil, Lari Lehtiö
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e46063 (2012)
Poly(ADP-ribosylation) is a post-translational covalent modification of proteins catalyzed by a family of enzymes termed poly(ADP-ribose) polymerases (PARPs). In the human genome, 17 different genes have been identified that encode members of the PAR
Externí odkaz:
https://doaj.org/article/4f1ce57c0d7f44758a1fe1246f865b22
Autor:
Anniina Virtanen, Maaria Palmroth, Sanna Liukkonen, Antti Kurttila, Teemu Haikarainen, Pia Isomäki, Olli Silvennoinen
Publikováno v:
Arthritis & Rheumatology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08b6d7bbf255f8765d91c25b103fd1eb
https://doi.org/10.1002/art.42547
https://doi.org/10.1002/art.42547
Publikováno v:
Nature chemical biology. 18(12)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::624dc6d4a71af9e4739768faa63313c5
https://pubmed.ncbi.nlm.nih.gov/36097296
https://pubmed.ncbi.nlm.nih.gov/36097296
Publikováno v:
Cancers
Cancers, Vol 13, Iss 800, p 800 (2021)
Cancers, Vol 13, Iss 800, p 800 (2021)
Simple Summary Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is a crucial cell signaling pathway that drives the development, differentiation, and function of immune cells and has an important role in blood cell f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c2715fcbfbf51c668627e3e923803585
http://europepmc.org/articles/PMC7918039
http://europepmc.org/articles/PMC7918039
Publikováno v:
Nucleic Acids Research
Human ARTD2 (or PARP2) is an ADP-ribosyltransferase, which is catalytically activated by binding to damaged DNA. ARTD2 subsequently ADP-ribosylates itself and other proteins, initiating a cascade of events leading to DNA repair. In contrast to ARTD1,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28d22ae536c110920744c70d32c6f660
https://doi.org/10.1093/nar/gky927
https://doi.org/10.1093/nar/gky927