Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Teemu D Laajala"'
Autor:
Majid Momeny, Mari Tienhaara, Mukund Sharma, Deepankar Chakroborty, Roosa Varjus, Iina Takala, Joni Merisaari, Artur Padzik, Andreas Vogt, Ilkka Paatero, Klaus Elenius, Teemu D Laajala, Kari J Kurppa, Jukka Westermarck
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 7, Pp 1603-1629 (2024)
Abstract Despite clinical benefits of tyrosine kinase inhibitors (TKIs) in cancer, most tumors can reactivate proliferation under TKI therapy. Here we present transcriptional profiling of HER2+ breast cancer cells transitioning from dormant drug tole
Externí odkaz:
https://doaj.org/article/709f9a596c0c46e4951cbcebf8781895
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 3, p e1010333 (2023)
In many real-world applications, such as those based on electronic health records, prognostic prediction of patient survival is based on heterogeneous sets of clinical laboratory measurements. To address the trade-off between the predictive accuracy
Externí odkaz:
https://doaj.org/article/95601469c59a46ffae4d1cb8885b145e
Autor:
Emrah Yatkin, Lauri Polari, Teemu D Laajala, Annika Smeds, Christer Eckerman, Bjarne Holmbom, Niina M Saarinen, Tero Aittokallio, Sari I Mäkelä
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e93764 (2014)
Prostate cancer is the most common cancer of men in the Western world, and novel approaches for prostate cancer risk reduction are needed. Plant-derived phenolic compounds attenuate prostate cancer growth in preclinical models by several mechanisms,
Externí odkaz:
https://doaj.org/article/d14b738881064640b6239fabf98a6d89
Autor:
Kalle E. Mattila, Teemu D. Laajala, Sara V. Tornberg, Tuomas P. Kilpeläinen, Paula Vainio, Otto Ettala, Peter J. Boström, Harry Nisen, Laura L. Elo, Panu M. Jaakkola
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract After surgery of localized renal cell carcinoma, over 20% of the patients will develop distant metastases. Our aim was to develop an easy-to-use prognostic model for predicting metastasis-free survival after radical or partial nephrectomy of
Externí odkaz:
https://doaj.org/article/f097036ba65447a59e243f07da006031
Autor:
Heidi M. Haikala, Johanna M. Anttila, Elsa Marques, Tiina Raatikainen, Mette Ilander, Henna Hakanen, Hanna Ala-Hongisto, Mariel Savelius, Diego Balboa, Bjoern Von Eyss, Vilja Eskelinen, Pauliina Munne, Anni I. Nieminen, Timo Otonkoski, Julia Schüler, Teemu D. Laajala, Tero Aittokallio, Harri Sihto, Johanna Mattson, Päivi Heikkilä, Marjut Leidenius, Heikki Joensuu, Satu Mustjoki, Panu Kovanen, Martin Eilers, Joel D. Leverson, Juha Klefström
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Elevated MYC levels can sensitize tumor cells to apoptosis. In this study, the authors demonstrate that AMPK activation and BCL-2/BCL-XL inhibition have a synergistic effect on apoptosis, and that together with anti PD-1 therapy they can suppress Myc
Externí odkaz:
https://doaj.org/article/d3f1f919795e44fe8702e5ba84a712b6
Autor:
Florus C. de Jong, Teemu D. Laajala, Robert F. Hoedemaeker, Kimberley R. Jordan, Angelique C. J. van der Made, Egbert R. Boevé, Deric K. E. van der Schoot, Bart Nieuwkamer, Emiel A. M. Janssen, Tokameh Mahmoudi, Joost L. Boormans, Dan Theodorescu, James C. Costello, Tahlita C. M. Zuiverloon
Publikováno v:
Science Translational Medicine, 15(697):eabn4118. American Association for the Advancement of Science
The recommended treatment for patients with high-risk non–muscle-invasive bladder cancer (HR-NMIBC) is tumor resection followed by adjuvant Bacillus Calmette-Guérin (BCG) bladder instillations. However, only 50% of patients benefit from this thera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2823e726d240ed6e5da274709fcb60cb
https://doi.org/10.1126/scitranslmed.abn4118
https://doi.org/10.1126/scitranslmed.abn4118
Autor:
Jukka Westermarck, Jeroen Pouwels, Olli Carpen, Ari Ristimäki, Denise C. Connolly, Teemu D. Laajala, Tiina Arsiola, Katja Kaipio, Caj Haglund, Ralf Butzow, Heini Lassus, Camilla Böckelman, Tove J. Grönroos, Kaisa Huhtinen, Umar Butt, Anna N. Cvrljevic
Supplementary Figure from Ovarian Cancers with Low CIP2A Tumor Expression Constitute an APR-246–Sensitive Disease Subtype
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::352a5a671124927daa8491821123b49c
https://doi.org/10.1158/1535-7163.22523778
https://doi.org/10.1158/1535-7163.22523778
Autor:
Jukka Westermarck, Jeroen Pouwels, Olli Carpen, Ari Ristimäki, Denise C. Connolly, Teemu D. Laajala, Tiina Arsiola, Katja Kaipio, Caj Haglund, Ralf Butzow, Heini Lassus, Camilla Böckelman, Tove J. Grönroos, Kaisa Huhtinen, Umar Butt, Anna N. Cvrljevic
Identification of ovarian cancer patient subpopulations with increased sensitivity to targeted therapies could offer significant clinical benefit. We report that 22% of the high-grade ovarian cancer tumors at diagnosis express CIP2A oncoprotein at lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::208942602e77502000159c1ec45d3a15
https://doi.org/10.1158/1535-7163.c.6543912.v1
https://doi.org/10.1158/1535-7163.c.6543912.v1
Autor:
Jukka Westermarck, Jeroen Pouwels, Olli Carpen, Ari Ristimäki, Denise C. Connolly, Teemu D. Laajala, Tiina Arsiola, Katja Kaipio, Caj Haglund, Ralf Butzow, Heini Lassus, Camilla Böckelman, Tove J. Grönroos, Kaisa Huhtinen, Umar Butt, Anna N. Cvrljevic
Supplementary Table from Ovarian Cancers with Low CIP2A Tumor Expression Constitute an APR-246–Sensitive Disease Subtype
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1966dc26b2af84ba180d71f6034d3590
https://doi.org/10.1158/1535-7163.22523769
https://doi.org/10.1158/1535-7163.22523769
Autor:
Jukka Westermarck, Jeroen Pouwels, Olli Carpen, Ari Ristimäki, Denise C. Connolly, Teemu D. Laajala, Tiina Arsiola, Katja Kaipio, Caj Haglund, Ralf Butzow, Heini Lassus, Camilla Böckelman, Tove J. Grönroos, Kaisa Huhtinen, Umar Butt, Anna N. Cvrljevic
Supplementary Data from Ovarian Cancers with Low CIP2A Tumor Expression Constitute an APR-246–Sensitive Disease Subtype
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b4996de6c859a3250132f93e0dd5998
https://doi.org/10.1158/1535-7163.22523976
https://doi.org/10.1158/1535-7163.22523976