Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Teddy Tat Chi Yang"'
Publikováno v:
FEBS Open Bio, Vol 13, Iss 7, Pp 1253-1265 (2023)
Lymphocyte activation gene‐3 (LAG‐3) is a type I transmembrane protein with structural similarities to CD4. Overexpression of LAG‐3 enables cancer cells to escape immune surveillance, while its blockade reinvigorates exhausted T cells and stren
Externí odkaz:
https://doaj.org/article/216df3dee63a4b2fa63793eda0416bbc
Developing high-affinity decoy receptors to treat multiple myeloma and diffuse large B cell lymphoma
Autor:
Yu Rebecca Miao, Kaushik Thakkar, Can Cenik, Dadi Jiang, Kazue Mizuno, Chenjun Jia, Caiyun Grace Li, Hongjuan Zhao, Anh Diep, Yu Xu, Xin Eric Zhang, Teddy Tat Chi Yang, Michaela Liedtke, Parveen Abidi, Wing-sze Leung, Albert C. Koong, Amato J. Giaccia
Publikováno v:
The Journal of experimental medicine. 219(9)
Disease relapse and treatment-induced immunotoxicity pose significant clinical challenges for patients with hematological cancers. Here, we reveal distinctive requirements for neutralizing TNF receptor ligands APRIL and BAFF and their receptor activi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fbc64f51524a6af98cc5634cdd33cbc
https://pubmed.ncbi.nlm.nih.gov/35881112
https://pubmed.ncbi.nlm.nih.gov/35881112
Autor:
Yu Rebecca Miao, Kaushik Thakker, Can Cenik, Dadi Jiang, Kazue Mizuno, Chenjun Jia, Caiyun Grace Li, Hongjuan Zhao, Anh Diep, Jimmy Yu Xu, Xin Eric Zhang, Teddy Tat Chi Yang, Michaela Liedtke, Parveen Abidi, Wing-sze Leung, Albert C. Koong, Amato J. Giaccia
B-cell maturation antigen (BCMA) expression is highly expressed on the surface of MM cells and has been used to target MM tumor cells by CAR-T, Antibody-Drug-Conjugates (ADCs) and BCMA-CD3 bispecific antibodies. However, BCMA is critical for the viab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f0a2b28ac08a35f083adc4ad45a2106
https://doi.org/10.1101/2021.05.03.442500
https://doi.org/10.1101/2021.05.03.442500
Autor:
Teddy Tat Chi Yang, Tiane Li, Yu Rebecca Miao, Bo Wei, Anh N. Diep, Haizea Alemany, Eui Jung Moon, Wei Huang, Amato J. Giaccia, Mihalis Kariolis, Yu Xu, Saravanan Nandagopal, Kaushik N. Thakkar, Yiren Xiao, Jin Qian, Erinn B. Rankin, Gerald Maxwell Cherf, Wenhua Yu
Publikováno v:
Clin Cancer Res
Purpose: Ovarian cancer represents a major clinical hurdle for immune checkpoint blockade (ICB), with reported low patient response rates. We found that the immune checkpoint ligand PD-L2 is robustly expressed in patient samples of ovarian cancers an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60c8ef058f21bc083507078bf8ce4b47
https://pubmed.ncbi.nlm.nih.gov/34011561
https://pubmed.ncbi.nlm.nih.gov/34011561
Neutralizing PD-L1 and PD-L2 Enhances the Efficacy of Immune Checkpoint Inhibitors in Ovarian Cancer
Autor:
Teddy Tat Chi Yang, Haizea Alemany, Amato J. Giaccia, Erinn B. Rankin, Saravanan Nandagopal, Eui Jung Moon, Wenhua Yu, Gerald Maxwell Cherf, Kaushik N. Thakkar, Yiren Xiao, Yu Rebecca Miao, Yu Xu, Anh N. Diep, Mihalis Kariolis, Tiane Li, Jin Qian, Bo Wei, Wei Huang
Immune checkpoint inhibitors targeting the PD-1/PD-L1 pathway have improved for a number of solid tumors. Unfortunately, ovarian cancer represents a major clinical hurdle for immune checkpoint blockade (ICB) with reported low patient response rates.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac3132f8be2e8de8c900623bafc7f0ee
https://doi.org/10.1101/2020.01.19.911941
https://doi.org/10.1101/2020.01.19.911941
Autor:
Jingxian Liu, Guiqun Wang, Liu Liu, Runjie Wu, Yi Wu, Cheng Fang, Xinhong Zhou, Jing Jiao, Ying Gu, He Zhou, Zhenhui Xie, Zhiwu Sun, Dakai Chen, Ken Dai, Dongxu Wang, Wei Tang, Teddy Tat Chi Yang
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Programmed cell death 1 (PD-1) monoclonal antibodies have been approved by regulatory agencies for the treatment of various types of cancer, and the mechanism involves the restoration of T cell functions. We report herein the X-ray crystal structure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d36b35a56de752459a3d3997a862e5fb
http://europepmc.org/articles/PMC6882818
http://europepmc.org/articles/PMC6882818