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Akademický článek

Unmasking GluN1/GluN3A excitatory glycine NMDA receptors

Autor: Teddy Grand, Sarah Abi Gerges, Mélissa David, Marco A. Diana, Pierre Paoletti

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)

Excitatory glycine GluN1/GluN3A receptors are atypical NMDARs that have been difficult to study. Here the authors identify new properties of these receptors, including potentiation by the GluN1 antagonist CGP-78608 that allows detection of functional

Externí odkaz: https://doaj.org/article/a35def0fe6364fabae0dd780be3a84b4

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Akademický článek

Higher ambient synaptic glutamate at inhibitory versus excitatory neurons differentially impacts NMDA receptor activity

Autor: Lulu Yao, Teddy Grand, Jesse E. Hanson, Pierre Paoletti, Qiang Zhou

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)

Inhibitory interneurons play important roles in brain circuits and in several neuropsychiatric disorders. Here, the authors show that excitatory synapses onto interneurons vs. excitatory neurons differ in their ambient synaptic glutamate level, a fin

Externí odkaz: https://doaj.org/article/feefe7905a1e4c1d9eb779cab0b0b4a6

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Akademický článek

Author Correction: Higher ambient synaptic glutamate at inhibitory versus excitatory neurons differentially impacts NMDA receptor activity

Autor: Lulu Yao, Teddy Grand, Jesse E. Hanson, Pierre Paoletti, Qiang Zhou

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)

The original version of this Article omitted the middle initial of the author Jesse E. Hanson. This has now been corrected in both the PDF and HTML versions of the Article.

Externí odkaz: https://doaj.org/article/1911f107c7844befa31fd140e1b5cd67

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Control of protein synthesis and memory by GluN3A-NMDA receptors through inhibition of GIT1/mTORC1 assembly

Autor: Fabrizio Gardoni, Isabel Pérez-Otaño, Sergio Niñerola, María J Conde-Dusman, John F. Wesseling, Steven J. Tavalin, Angel Barco, Óscar Elía-Zudaire, Partha N Dey, Luis G. Rabaneda, Eric R. Velasco, Teddy Grand, Raül Andero, Víctor Briz, Pierre Paoletti, Carmen García-Lira

Publikováno v: eLife, Vol 10 (2021)
eLife
Digital.CSIC. Repositorio Institucional del CSIC
instname

De novo protein synthesis is required for synapse modifications underlying stable memory encoding. Yet neurons are highly compartmentalized cells and how protein synthesis can be regulated at the synapse level is unknown. Here, we characterize neuron

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6f3c872fd640b9abe467f54d9230688
http://hdl.handle.net/10261/263921

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Control of aversion by glycine-gated GluN1/GluN3A NMDA receptors in the adult medial habenula

Autor: Stéphane Dieudonné, Charly V. Rousseau, Pierre Paoletti, Cendra Agulhon, Teddy Grand, Marco A. Diana, Yo Otsu, Eric J Schwartz, T. Bessaih, S. Abi Gerges, Brigitte L. Kieffer, Ferenc Mátyás, K. Pietrajtis, László Acsády, Emmanuel Darcq

Publikováno v: Science
Science, 2019, 366 (6462), pp.250-254. ⟨10.1126/science.aax1522⟩
Science, American Association for the Advancement of Science, 2019, 366 (6462), pp.250-254. ⟨10.1126/science.aax1522⟩

An inhibitor causes neuronal excitation Glycine is thought to be primarily an inhibitory neurotransmitter. However, it also acts as a coagonist on excitatory N -methyl-D-aspartate (NMDA) receptors. Otsu et al. examined the function of the NMDA recept

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e84330689c78715794916ae66051e05

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Akademický článek

Activation of Nod2 signaling upon norovirus infection enhances antiviral immunity and susceptibility to colitis

Autor: Ghaffar Muharram, Marion Thépaut, Pierre-Emmanuel Lobert, Teddy Grandjean, Olivier Boulard, Myriam Delacre, Emmrich Wakeford, Richard Wheeler, Lionel Franz Poulin, Ivo Gomperts Boneca, Frank Lafont, Marie-Cécile Michallet, Didier Hober, Ken Cadwell, Mathias Chamaillard

Publikováno v: Gut Microbes, Vol 15, Iss 2 (2023)

ABSTRACTOver 90% of epidemic non-bacterial gastroenteritis are caused by human noroviruses (NoVs), which persist in a substantial subset of people allowing their spread worldwide. This has led to a significant number of endemic cases and up to 70,000

Externí odkaz: https://doaj.org/article/82e1ea85018e431fa5bf296b5b136da8

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Akademický článek

The natriuretic peptide receptor agonist osteocrin disperses Pseudomonas aeruginosa biofilm

Autor: Melissande Louis, Ali Tahrioui, Courtney J. Lendon, Thomas Clamens, Jérôme Leprince, Benjamin Lefranc, Eric Kipnis, Teddy Grandjean, Emeline Bouffartigues, Magalie Barreau, Florian Defontaine, Pierre Cornelis, Marc G.J. Feuilloley, Nicholas J. Harmer, Sylvie Chevalier, Olivier Lesouhaitier

Publikováno v: Biofilm, Vol 5, Iss , Pp 100131- (2023)

Biofilms are highly tolerant to antimicrobials and host immune defense, enabling pathogens to thrive in hostile environments. The diversity of microbial biofilm infections requires alternative and complex treatment strategies. In a previous work we d

Externí odkaz: https://doaj.org/article/1b229d2ec4884c798d30e92f1eca88f4

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Author Correction: Higher ambient synaptic glutamate at inhibitory versus excitatory neurons differentially impacts NMDA receptor activity

Autor: Teddy Grand, Pierre Paoletti, Lulu Yao, Jesse E. Hanson, Qiang Zhou

Publikováno v: Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)

Selective disruption of synaptic drive to inhibitory neurons could contribute to the pathophysiology of various brain disorders. We have previously identified a GluN2A-selective positive allosteric modulator, GNE-8324, that selectively enhances N-met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d83fc07ff99e13b30bed27bee5551c37
https://doi.org/10.1038/s41467-018-07441-1

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An inter‐dimer allosteric switch controls NMDA receptor activity

Autor: Pierre Paoletti, Lonnie P. Wollmuth, David Stroebel, Antoine Taly, Kelvin Chan, Jean-Baptiste Esmenjaud, Mélissa David, Teddy Grand

Publikováno v: The EMBO Journal
EMBO Journal
EMBO Journal, 2018, 38 (2), pp.e99894. ⟨10.15252/embj.201899894⟩
EMBO Journal, EMBO Press, 2018, 38 (2), pp.e99894. ⟨10.15252/embj.201899894⟩

International audience; NMDA receptors (NMDARs) are glutamate-gated ion channels that are key mediators of excitatory neurotransmission and synaptic plasticity throughout the central nervous system. They form massive heterotetrameric complexes endowe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9db5d49c8d839a7508a73b138ac8e918
https://doi.org/10.15252/embj.201899894

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