Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Ted William Harris"'
Autor:
Gloria S. Forkuo, James M. Cook, Gene T. Yocum, Revathi Kodali, Leggy A. Arnold, Rajwana Jahan, Michael Rajesh Stephen, Margaret L. Guthrie, Douglas A. Steeber, Charles W. Emala, Douglas C. Stafford, Olivia B. Yu, Guanguan Li, Nicolas M Zahn, Ted William Harris, Janet L. Fisher, Amanda N. Nieman, M S Rashid Roni
Publikováno v:
Molecular Pharmaceutics. 15:1766-1777
We describe lead compound MIDD0301 for the oral treatment of asthma based on previously developed positive allosteric α(5)β(3)γ(2) selective GABA(A) receptor (GABA(A)R) ligands. MIDD0301 relaxed airway smooth muscle at single micromolar concentrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b93345b08045b2b3af1122f8fda4a35
https://doi.org/10.1021/acs.molpharmaceut.7b01013
https://doi.org/10.1021/acs.molpharmaceut.7b01013
Autor:
Michael M. Poe, James M. Cook, Douglas C. Stafford, Leggy A. Arnold, Amanda N. Nieman, Nicolas M Zahn, Michael Rajesh Stephen, Ted William Harris, Guanguan Li, Revathi Kodali, Gene T. Yocum, Rajwana Jahan, Charles W. Emala, Benjamin D. Hartzler, Olivia B. Yu, Margaret L. Guthrie, Nina Y. Yuan, Douglas A. Steeber, Gloria S. Forkuo
Publikováno v:
Molecular Pharmaceutics. 14:2088-2098
We describe pharmacokinetic and pharmacodynamic properties of two novel oral drug candidates for asthma. Phenolic α4β3γ2 GABAAR selective compound 1 and acidic α5β3γ2 selective GABAAR positive allosteric modulator compound 2 relaxed airway smoo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5755a9d9e97f0233975c5000c7783d33
https://doi.org/10.1021/acs.molpharmaceut.7b00183
https://doi.org/10.1021/acs.molpharmaceut.7b00183