Comprehensive characterization of 536 patient-derived xenograft models prioritizes candidatesfor targeted treatment

Autor: Li Chen, Jacqueline Mudd, Michael Ittmann, Carol J. Bult, Amanda R. Kirane, Jelena Randjelovic, Stephen Scott, Yige Wu, Li Ding, Vashisht G. Yennu-Nanda, Jing Wang, Christopher D. Lanier, Maihi Fujita, Emilio Cortes-Sanchez, Sienna Rocha, Susan G. Hilsenbeck, Kian-Huat Lim, Fernanda Martins Rodrigues, Jill Rubinstein, Nicholas Mitsiades, Haiyin Lin, Jayamanna Wickramasinghe, Andrew Butterfield, Bryan E. Welm, Alana L. Welm, Jose P. Zevallos, Jason Held, Nicole B. Coggins, Song Cao, Yuanxin Xi, Brenda C. Timmons, Paul Lott, David Menter, Shunqiang Li, Tina Primeau, Fei Yang, Andrea Wang-Gillam, Ramaswamy Govindan, Dali Li, Brandi Davis-Dusenbery, Sara Seepo, Michael C. Wendl, Jeffrey Grover, Brian S. White, Clifford G. Tepper, Peter N. Robinson, Michael A. Davies, Zhengtao Chu, Michael W. Lloyd, Hua Sun, Xiaoshan Zhang, Tamara Stankovic, Dylan Fingerman, Anuj Srivastava, Luis G. Carvajal-Carmona, Don L. Gibbons, Lijun Yao, Rebecca Aft, Hongyong Zhang, Ismail Meraz, John DiGiovanna, Scott Kopetz, Ling Zhao, Guadalupe Polanco-Echeverry, Feng Chen, Jeremy Hoog, Matthew A. Wyczalkowski, George Xu, John D. Minna, Yi Xu, Julie Belmar, Xiaowei Xu, Luc Girard, Dennis A. Dean, Tijana Borovski, Chong-xian Pan, Cynthia X. Ma, Alexa Morales Arana, Yize Li, Turcin Saridogan, Steven B. Neuhauser, Sandra Scherer, Vicki Chin, Rose Tipton, David R. Gandara, Sherri R. Davies, Argun Akcakanat, Rajesh Patidar, Julie K. Schwarz, Soner Koc, Gao Boning, Michael Kim, Bryce P. Kirby, Yvonne A. Evrard, Hyunsil Park, Christian Frech, Chia-Kuei Mo, Ran Zhang, Brian A. Van Tine, Jonathan W. Reiss, Min Xiao, Xing Yi Woo, Tiffany Le, Ana Estrada, Xiaofeng Zheng, Jeffrey A. Moscow, Mourad Majidi, Nadezhda V. Terekhanova, Katherine Fuh, Erkan Yuca, Timothy A. Yap, Jianhua Zhang, Matthew J. Ellis, Shannon Westin, James H. Doroshow, Vito W. Rebecca, Moon S. Chen, Coya Tapia, Reyka G Jayasinghe, Jack A. Roth, Jithesh Augustine, Ryan C. Fields, Michae T. Tetzlaff, Michael T. Lewis, Kurt W. Evans, Ralph W. deVere White, Brian J. Sanderson, May Cho, Jeffrey H. Chuang, Tiffany Wallace, Ryan Jeon, Ted Toal, Matthew H. Bailey, Bert W. O'Malley, Katherine L. Nathanson, Qin Liu, Benjamin J. Raphael, Jingqin Luo, Salma Kaochar, Huiqin Chen, Rajasekharan Somasundaram, Daniel Cui Zhou, John F. DiPersio, Andrew V. Kossenkov, Bingliang Fang, Vanessa Jensen, Simone Zaccaria, Alexey Sorokin, Ai-Hong Ma, Sidharth V. Puram, Min Jin Ha, Meenhard Herlyn, R. Jay Mashl, Kelly Gale, Bingbing Dai, Lacey E. Dobrolecki, Chieh-Hsiang Yang, Funda Meric-Bernstam

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Nature Communications

Development of candidate cancer treatments is a resource-intensive process, with the research community continuing to investigate options beyond static genomic characterization. Toward this goal, we have established the genomic landscapes of 536 pati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6a532801486680203051ed293ca8f82
https://doaj.org/article/e6286532f9bc487a87943a142621d7a3

Abstract 2274: Identification of predisposition and progression gastric cancer biomarkers in Latinos

Autor: Ana Patricia Estrada-Florez, Paul Lott, Ted Toal, Nicole Halmai, Elizabeth Quino, Alma Poceros-Coba, Alix Guevara, Fabian Castro, Jhon Suarez, John Mcpherson, Rasika Venkatesh, Hongyong Zhang, Apri Vang, Guadalupe Polanco, Joana Guerra, Graciela Molina, Carol Parra, Adriana Della Valle, Esteban Castelao, Manuel Teixeira, Mabel Bohorquez, Javier Torres, Alejandro Carvajal Corvalan, Luis G. Carvajal-Carmona

Publikováno v: Cancer Research. 82:2274-2274

Gastric cancer (GC) disproportionally affects people of Latino ancestry and represent a leading cause of incidence and mortality disparities in this minority populations. When compared to Non-Latino Whites, Latinos are ~2-fold more likely to be diagn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::44cceeb6560e12abbb5f6553f18fc359
https://doi.org/10.1158/1538-7445.am2022-2274

Translational regulation contributes to the elevated CO2 response in two Solanum species

Autor: Daniel E. Runcie, Ted Toal, Kaisa Kajala, Joel Rodriguez-Medina, Samuel Rusoff, Sharon B. Gray, Siobhan M. Brady

Publikováno v: The Plant journal : for cell and molecular biology, vol 102, iss 2
The Plant Journal
Plant Journal, 102(2), 383. Blackwell Publishing Ltd

Summary Understanding the impact of elevated CO2 (eCO2) in global agriculture is important given climate change projections. Breeding climate‐resilient crops depends on genetic variation within naturally varying populations. The effect of genetic v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::953bd06f7af787e6769d05a87f954498
https://escholarship.org/uc/item/3880v69d

Regulation of Root Angle and Gravitropism

Autor: Rohan V. Patel, Donald Gibson, Allison Gaudinier, Wolfgang Busch, Nicholas J. Provart, Nathan D. Miller, Kaisa Kajala, Edgar P. Spalding, Daniel J. Kliebenstein, Siobhan M. Brady, Bessie L. Splitt, Miguel de Lucas, Mily Ron, Logan S. Johnson, Ted Toal, Radka Slovak

Publikováno v: G3 (Bethesda, Md.), vol 8, iss 12
G3: Genes, Genomes, Genetics, Vol 8, Iss 12, Pp 3841-3855 (2018)
G3: Genes|Genomes|Genetics
G3: Genes, Genomes, Genetics, 8(12), 3841. Genetics Society of America

Regulation of plant root angle is critical for obtaining nutrients and water and is an important trait for plant breeding. A plant’s final, long-term root angle is the net result of a complex series of decisions made by a root tip in response to ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc3e07a4de2d1324221d2fdde8b59743
https://escholarship.org/uc/item/8241p8sq

Abstract PR15: Intratumoral heterogeneity in Latino gastric adenocarcinomas

Autor: Amanda Kirane, Ted Toal, Luis G. Carvajal Carmona, Mabel Bohorquez, Javier Torres, Magdalena Echeverry, Shiro Urayama, Guadalupe María Polanco Echeverry, Ruta Sahasrabudhe

Publikováno v: Cancer Epidemiology, Biomarkers & Prevention. 29:PR15-PR15

The goal of this study was to examine gastric (stomach) cancer mutational intratumoral heterogeneity (ITH) in Latinos using multiregion sequencing (MSEQ). Gastric cancer is the 2nd leading cause of cancer-related death worldwide. It is diagnosed in 2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3746c203d527550e92a1e92ed3491afa
https://doi.org/10.1158/1538-7755.disp19-pr15