Zobrazeno 1 - 7 of 7 pro vyhledávání: '"Ted Petley"'
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Monoclonal antibodies targeting ST2L Domain 1 or Domain 3 differentially modulate IL-33-induced cytokine release by human mast cell and basophilic cell lines
Autor: Robert A. Lamb, Yawei Li, Ramachandra Reddy, Brian Jones, Eilyn R. Lacy, Angela Filer, Jin Lu, Catherine Healy, Changbao Liu, Karen E. Duffy, Ted Petley, Sheng-Jiun Wu, Natalie Fursov
Publikováno v: Molecular immunology. 75
The cell-surface receptor ST2L triggers cytokine release by immune cells upon exposure to its ligand IL-33. To study the effect of ST2L-dependent signaling in different cell types, we generated antagonist antibodies that bind different receptor domai
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ee1f6831b509492255249ceba4d8773
https://pubmed.ncbi.nlm.nih.gov/27294560
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4
Novel antagonist antibody to TLR3 blocks poly(I:C)-induced inflammation in vivo and in vitro
Autor: Karen E. Duffy, Rachel A Bunting, Lena Alexopoulou, Karen A Smalley, Heena Beck, Richard A. Flavell, Ted Petley, Xuesong Liu, Jamie Fisher, Lani San Mateo, Christine K. Ward, Roberta J. Lamb, Holly Raymond
Publikováno v: Cellular Immunology. 267:9-16
Toll-like receptor 3 (TLR3) binds and signals in response to dsRNA and poly(I:C), a synthetic double stranded RNA analog. Activation of TLR3 triggers innate responses that may play a protective or detrimental role in viral infections or in immune-med
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f599a64692671013578181b4d4ebeed
https://doi.org/10.1016/j.cellimm.2010.10.008
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5
Therapeutic dosing with anti-interleukin-13 monoclonal antibody inhibits asthma progression in mice
Autor: Li Li, Eva Emmell, Ted Petley, Gaoyun Yang, Peter J. Bugelski, Jill Giles-Komar, Don E. Griswold, Mani Lakshminarayanan, Amy Volk, Patricia Rafferty, Anuk Das
Publikováno v: The Journal of pharmacology and experimental therapeutics. 313(1)
In vivo models have demonstrated that interleukin-13 (IL-13) plays an important role in asthma; however, few studies have evaluated the effect of inhibition of IL-13 on established and persistent disease. In the present study, we have investigated th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f577137d354093cf7baa454527b9761b
https://pubmed.ncbi.nlm.nih.gov/15644434
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6
Effects of interferon-a and interferon-b on development of antigen-specific B cells and hybridoma generation (38.28)
Autor: Sandra Santulli-Marotto, Ted Petley, Jamie Fisher, Jennifer Pitcher, Michael Rycyzyn, Jill Giles-Komar
Publikováno v: The Journal of Immunology. 182:38.28-38.28
The ratio of Interferon-α (IFN-α) and Interferon-β (IFN-β) produced during an immune response can significantly impact the outcome. We find that administration of IFN-α and IFN-β during immunization can alter the fate of antigen-specific B cell
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d1754131142ae0a053fc73f585990a29
https://doi.org/10.4049/jimmunol.182.supp.38.28
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7
Generation of a protective T cell response following viral infection of the CNS is independent of either IL-12 or IL-23 (B141)
Autor: Katherine Held, William Glass, Yevgeniya Orlovsky, Kimberly Shamberger, Ted Petley, Patrick Branigan, Mark Cunningham, Jacqueline Benson, Thomas Lane
Publikováno v: The Journal of Immunology. 178:LB29-LB29
The functional role of IL-12 and IL-23 in generating effector T cells following viral infection of the central nervous system (CNS) was determined. Instillation of mouse hepatitis virus (MHV) into the CNS of C57BL/6 mice results in an acute encephali
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0497ee3daf735417e2886924a760509c
https://doi.org/10.4049/jimmunol.178.supp.b141
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