Zobrazeno 1 - 10
of 154
pro vyhledávání: '"Ted H, Hansen"'
Autor:
Xiuli Zhang, S. Peter Goedegebuure, Michael Y. Chen, Rashmi Mishra, Felicia Zhang, Yik Yeung Yu, Kartik Singhal, Lijin Li, Feng Gao, Nancy B. Myers, Tammi Vickery, Jasreet Hundal, Michael D. McLellan, Mark A. Sturmoski, Samuel W. Kim, Ina Chen, Jesse T. Davidson, Narendra V. Sankpal, Stephanie Myles, Rama Suresh, Cynthia X. Ma, Ademuyiwa Foluso, Andrea Wang-Gillam, Sherri Davies, Ian S. Hagemann, Elaine R. Mardis, Obi Griffith, Malachi Griffith, Christopher A. Miller, Ted H. Hansen, Timothy P. Fleming, Robert D. Schreiber, William E. Gillanders
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-17 (2024)
Abstract Background Neoantigen vaccines can induce or enhance highly specific antitumor immune responses with minimal risk of autoimmunity. We have developed a neoantigen DNA vaccine platform capable of efficiently presenting both HLA class I and II
Externí odkaz:
https://doaj.org/article/361f87535f3347da8e2cfda87d75ab59
Autor:
Lijin Li, Xiuli Zhang, Xiaoli Wang, Samuel W. Kim, John M. Herndon, Michelle K. Becker-Hapak, Beatriz M. Carreno, Nancy B. Myers, Mark A. Sturmoski, Michael D. McLellan, Christopher A. Miller, Tanner M. Johanns, Benjamin R. Tan, Gavin P. Dunn, Timothy P. Fleming, Ted H. Hansen, S. Peter Goedegebuure, William E. Gillanders
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-13 (2021)
Abstract Background Preclinical studies and early clinical trials have shown that targeting cancer neoantigens is a promising approach towards the development of personalized cancer immunotherapies. DNA vaccines can be rapidly and efficiently manufac
Externí odkaz:
https://doaj.org/article/031af79ff43e4bff85ce49e20a87cccb
Autor:
Xiaoli Wang, Sytse J Piersma, Christopher A Nelson, Ya-Nan Dai, Ted Christensen, Eric Lazear, Liping Yang, Marjolein Sluijter, Thorbald van Hall, Ted H Hansen, Wayne M Yokoyama, Daved H Fremont
Publikováno v:
eLife, Vol 7 (2018)
A recurrent theme in viral immune evasion is the sabotage of MHC-I antigen presentation, which brings virus the concomitant issue of ‘missing-self’ recognition by NK cells that use inhibitory receptors to detect surface MHC-I proteins. Here, we r
Externí odkaz:
https://doaj.org/article/c9672d426e5e45eca7a97f1415a0cf7e
Autor:
Stephanie Myles, Michael Y. Chen, Malachi Griffith, Andrea Wang-Gillam, Feng Gao, Sherri R. Davies, Elaine R. Mardis, S. Peter Goedegebuure, Samuel W. Kim, Ian S. Hagemann, Lijin Li, Timothy P. Fleming, Ademuyiwa Foluso, Tammi L. Vickery, Narendra V. Sankpal, Mark A. Sturmoski, Jesse T. Davidson, Nancy B. Myers, Christopher A. Miller, Michael D. McLellan, Ina Chen, Jasreet Hundal, William E. Gillanders, Robert D. Schreiber, Ted H. Hansen, Cynthia X. Ma, Rama Suresh, Xiuli Zhang
PURPOSECancer neoantigens are important targets of cancer immunotherapy. Neoantigen vaccines have the potential to induce or enhance highly specific antitumor immune responses with minimal risk of autoimmunity. We have developed a neoantigen DNA vacc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b784ed165f1ac0b7715faff30393939
https://doi.org/10.1101/2021.11.19.21266466
https://doi.org/10.1101/2021.11.19.21266466
Autor:
Mary H Young, Lance U'Ren, Shouxiong Huang, Thierry Mallevaey, James Scott-Browne, Frances Crawford, Olivier Lantz, Ted H Hansen, John Kappler, Philippa Marrack, Laurent Gapin
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e53789 (2013)
Mucosal-associated invariant T cells are a unique population of T cells that express a semi-invariant αβ TCR and are restricted by the MHC class I-related molecule MR1. MAIT cells recognize uncharacterized ligand(s) presented by MR1 through the cog
Externí odkaz:
https://doaj.org/article/ffbe0134aa6c4b8e9d6313e04ba00c8b
Publikováno v:
PLoS Biology, Vol 10, Iss 11, p e1001432 (2012)
One of the hallmarks of viral immune evasion is the capacity to disrupt major histocompatibility complex class I (MHCI) antigen presentation to evade T-cell detection. Cowpox virus encoded protein CPXV203 blocks MHCI surface expression by exploiting
Externí odkaz:
https://doaj.org/article/ad8a7504273d4acea0b6087276bf849c
Autor:
Marielle C Gold, Stefania Cerri, Susan Smyk-Pearson, Meghan E Cansler, Todd M Vogt, Jacob Delepine, Ervina Winata, Gwendolyn M Swarbrick, Wei-Jen Chua, Yik Y L Yu, Olivier Lantz, Matthew S Cook, Megan D Null, David B Jacoby, Melanie J Harriff, Deborah A Lewinsohn, Ted H Hansen, David M Lewinsohn
Publikováno v:
PLoS Biology, Vol 8, Iss 6, p e1000407 (2010)
Control of infection with Mycobacterium tuberculosis (Mtb) requires Th1-type immunity, of which CD8+ T cells play a unique role. High frequency Mtb-reactive CD8+ T cells are present in both Mtb-infected and uninfected humans. We show by limiting dilu
Externí odkaz:
https://doaj.org/article/d438072d9b3a4f378beabc48f892f372
Autor:
Savas D. Soysal, Xiuli Zhang, Mark A. Sturmoski, Michael D. McLellan, John M. Herndon, Ian S. Hagemann, Nancy B. Myers, Samuel Kim, Shunqiang Li, Tina Primeau, Peter S. Goedegebuure, Lijin Li, Allegra A. Petti, Elaine R. Mardis, Ted H. Hansen, William E. Gillanders, Jasreet Hundal, Christopher A. Miller, Timothy P. Fleming, Tammi L. Vickery, Jeremy Hoog, Matthew J. Ellis
Publikováno v:
Cancer Immunology Research. 5:516-523
Next-generation sequencing technologies have provided insights into the biology and mutational landscape of cancer. Here, we evaluate the relevance of cancer neoantigens in human breast cancers. Using patient-derived xenografts from three patients wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c200d8ba39a4474c1d9462b84ac6d7fc
https://doi.org/10.1158/2326-6066.cir-16-0264
https://doi.org/10.1158/2326-6066.cir-16-0264
Autor:
Timothy P. Fleming, Michelle Becker-Hapak, Lijin Li, Beatriz M. Carreno, Tanner M. Johanns, Ted H. Hansen, John M. Herndon, S. Peter Goedegebuure, Michael D. McLellan, Xiuli Zhang, Christopher A. Miller, Benjamin R. Tan, Samuel W. Kim, Gavin P. Dunn, Xiaoli Wang, Mark A. Sturmoski, Nancy B. Myers, William E. Gillanders
Publikováno v:
Genome Medicine
Genome Medicine, Vol 13, Iss 1, Pp 1-13 (2021)
Genome Medicine, Vol 13, Iss 1, Pp 1-13 (2021)
BackgroundPreclinical studies and early clinical trials have shown that targeting cancer neoantigens is a promising approach towards the development of personalized cancer immunotherapies. DNA vaccines can be rapidly and efficiently manufactured and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3be19b575e57baa4b6809f2e0989c033
https://pubmed.ncbi.nlm.nih.gov/33879241
https://pubmed.ncbi.nlm.nih.gov/33879241
Autor:
Saghar Kaabinejadian, William H. Hildebrand, Aaron D. Martin, Jon A. Weidanz, Curtis McMurtrey, Fredda Schafer, Sojung Kim, Ted H. Hansen, Wilfried Bardet, Rinki Jain, Jason L. Davenport, Michael S. Diamond
Publikováno v:
The Journal of Immunology. 196:4263-4273
Class I Human Leukocyte Antigens (HLA) mark infected cells for immune targeting by presenting pathogen encoded peptides on the cell surface. Characterization of viral peptides unique to infected cells is important for understanding CD8+ T cell respon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a72f73bc29788c6937db7b6bf7d6b218
https://doi.org/10.4049/jimmunol.1501821
https://doi.org/10.4049/jimmunol.1501821