Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Ted G. Graber"'
Autor:
Megan L. Pajski, Chris Byrd, Nainika Nandigama, Emily Seguin, Anna Seguin, Alyssa Fennell, Ted G. Graber
Publikováno v:
Frontiers in Aging, Vol 5 (2024)
Exercise has been shown to improve physical function, mitigate aspects of chronic disease and to potentially alter the trajectory of age-related onset of frailty and sarcopenia. Reliable and valid preclinical models are necessary to elucidate the und
Externí odkaz:
https://doaj.org/article/0ca715fe0dca4e7e9ab3def825ea0304
Autor:
Ted G. Graber, Rosario Maroto, Jill K. Thompson, Steven G. Widen, Zhaohui Man, Megan L. Pajski, Blake B. Rasmussen
Publikováno v:
Journal of Ageing and Longevity, Vol 3, Iss 2, Pp 159-178 (2023)
One inevitable consequence of aging is the gradual deterioration of physical function and exercise capacity, driven in part by the adverse effect of age on muscle tissue. We hypothesized that relationships exist between age-related differentially exp
Externí odkaz:
https://doaj.org/article/1b08a17837f44e75b8e7572f5c2f07ce
Publikováno v:
Nutrition & Metabolism, Vol 14, Iss 1, Pp 1-11 (2017)
Abstract Background Amino acid availability stimulates protein synthesis via the mTORC1 (mechanistic target of rapamycin complex 1) signaling pathway. In response to an increase in cellular amino acid availability, translocation of cytosolic mTORC1 t
Externí odkaz:
https://doaj.org/article/6ebc5d87cac84fa5bbf93e9a0f2124a8
Autor:
Rasmussen, Ted G. Graber, Rosario Maroto, Jill K. Thompson, Steven G. Widen, Zhaohui Man, Megan L. Pajski, Blake B.
Publikováno v:
Journal of Ageing and Longevity; Volume 3; Issue 2; Pages: 159-178
One inevitable consequence of aging is the gradual deterioration of physical function and exercise capacity, driven in part by the adverse effect of age on muscle tissue. We hypothesized that relationships exist between age-related differentially exp
Publikováno v:
J Gerontol A Biol Sci Med Sci
The inability of older adults to maintain independence is a consequence of sarcopenia and frailty. In order to identify the molecular mechanisms responsible for decreased physical function, it will be critical to utilize a small animal model. The mai
With age comes a gradual decline in physical function and exercise capacity, concurrent with a progressive propensity for development of sarcopenia /(age-related loss of muscle mass and strength) and frailty (inability of body to thrive and maintain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7bfea5a46b5abd05121d2f6c64d77769
https://doi.org/10.1101/2021.05.20.445050
https://doi.org/10.1101/2021.05.20.445050
Autor:
Christopher S. Fry, Stanley J. Watowich, Camille R. Brightwell, Stanton F. McHardy, Ted G. Graber, Hua Yu Leo Wang, Rosario Maroto, Harshini Neelakantan, John Papaconstantinou
Publikováno v:
Biochem Pharmacol
Aging is accompanied by progressive declines in skeletal muscle mass and strength and impaired regenerative capacity, predisposing older adults to debilitating age-related muscle deteriorations and severe morbidity. Muscle stem cells (muSCs) that pro
Publikováno v:
GeroScience. 41:165-183
Sarcopenia, the age-related loss of muscle mass and strength, contributes to frailty, functional decline, and reduced quality of life in older adults. Exercise is a recognized therapy for sarcopenia and muscle dysfunction, though not a cure. Muscle p
Autor:
Maki Wakamiya, Camille R. Brightwell, Ted G. Graber, Tatiana Moro, Blake B. Rasmussen, Christopher S. Fry, Rosario Maroto, Craig Porter, Nisha Bhattarai
Publikováno v:
Journal of Biological Chemistry. 294:4091-4102
mTORC1 regulates protein synthesis and in turn is regulated by growth factors, energy status, and amino acid availability. In kidney cell (HEK293-T) culture, the GAP activity toward RAG (GATOR1) protein complex suppresses activation of the RAG A/B–
Autor:
Ted G. Graber, Matthew Borkowski, Christopher S. Fry, Benjamin D. Brightwell, Camille R. Brightwell, Brian Noehren
Publikováno v:
J Vis Exp
Skeletal muscle plasticity in response to countless conditions and stimuli mediates concurrent functional adaptation, both negative and positive. In the clinic and the research laboratory, maximal muscular strength is widely measured longitudinally i