Výsledky vyhledávání - "Ted Bambakidis"

Early Treatment With a Single Dose of Mesenchymal Stem Cell Derived Extracellular Vesicles Modulates the Brain Transcriptome to Create Neuroprotective Changes in a Porcine Model of Traumatic Brain Injury and Hemorrhagic Shock

Autor: Ted Bambakidis, Benjamin Buller, Aaron M. Williams, Simone E. Dekker, Zachary Pickell, Umar F. Bhatti, Ben E. Biesterveld, Yongqing Li, Baoling Liu, Hasan B. Alam

Publikováno v: Shock. 57:281-290

BACKGROUND Cell-based therapies using mesenchymal stem cell derived extracellular vesicles (EVs) improve neurologic outcomes in animal models of traumatic brain injury (TBI), stroke, and hemorrhage. Using a porcine 7-day survival model of TBI and hem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2e4cd2b6765c5316ba654a9c8267f45
https://doi.org/10.1097/shk.0000000000001889

Zobrazit plný text záznamu

Modulation of Brain Transcriptome by Combined Histone Deacetylase Inhibition and Plasma Treatment Following Traumatic Brain Injury and Hemorrhagic Shock

Autor: Hasan B. Alam, Rebecca Tagett, Simone E. Dekker, Ted Bambakidis, Aaron M. Williams, Craig N. Johnson, Martin Sillesen, Ben E. Biesterveld, Yongqing Li, Baoling Liu

Publikováno v: Shock. 55:110-120

Introduction We previously showed that the addition of valproic acid (VPA), a histone deacetylase inhibitor, to fresh frozen plasma (FFP) resuscitation attenuates brain lesion size and swelling following traumatic brain injury (TBI) and hemorrhagic s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9c6ece9c0397149c3f7d1ab97e1ebc9
https://doi.org/10.1097/shk.0000000000001605

Zobrazit plný text záznamu

Unraveling the Cytoprotective Effects of Valproic Acid: A Transcriptomics Meta-Analysis of Transfusion Strategies for Hemorrhagic Shock and Traumatic Brain Injury

Autor: Simone E. Dekker, Hasan B. Alam, Yongqing Li, Baoling Liu, Martin Sillesen, Ted Bambakidis

Publikováno v: Blood. 138:3245-3245

Introduction: Traumatic brain injury (TBI) results in widespread impairment of hemostasis, fibrinolysis, coagulation, endothelial function, and immune function. While damage control resuscitation (DCR) is a well-established treatment strategy for lif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::59e806e20a793c7e16ef2371b3ae1ba7
https://doi.org/10.1182/blood-2021-151075

Zobrazit plný text záznamu

Early Transfusion with Mesenchymal Stem Cell Derived Extracellular Vesicles: A New Transfusion Strategy for Life-Threatening Hemorrhage and Traumatic Brain Injury

Autor: Simone E. Dekker, Umar F. Bhatti, Aaron M. Williams, Yongqing Li, Zachary Pickell, Benjamin Buller, Hasan B. Alam, Ted Bambakidis, Ben E. Biesterveld

Publikováno v: Blood. 138:1071-1071

Background: Life-threatening hemorrhage and traumatic brain injury (TBI) have a significantly increasing global burden and remain leading causes of preventable deaths. Effective interventions may protect the brain against ongoing damage and improve t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::94b97a7ea36362e696f3c0718429ccba
https://doi.org/10.1182/blood-2021-150850

Zobrazit plný text záznamu

Valproic acid modulates platelet and coagulation function ex vivo

Autor: Patryk Piascik, Ted Bambakidis, Ihab Halaweish, Yongqing Li, Patrick E. Georgoff, Vahagn C. Nikolian, Simone E. Dekker, Martin Sillesen, Hasan B. Alam, Baoling Liu

Publikováno v: Blood Coagulation & Fibrinolysis. 28:479-484

Trauma-induced coagulopathy is associated with adverse patient outcome. Animal models demonstrate that histone deacetylase inhibitors, such as valproic acid (VPA), improve survival following injury. While in-vivo data suggest that improved survival m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3f4d1c317e941af7e67054a4889e4d5
https://doi.org/10.1097/mbc.0000000000000626

Zobrazit plný text záznamu

Different resuscitation strategies and novel pharmacologic treatment with valproic acid in traumatic brain injury

Autor: Martin Sillesen, Simone E. Dekker, Patrick Schober, Ted Bambakidis, Hasan B. Alam, Vahagn C. Nikolian

Publikováno v: Journal of Neuroscience Research, 96, 711-719. Wiley-Liss Inc.
Dekker, S E, Nikolian, V C, Sillesen, M, Bambakidis, T, Schober, P & Alam, H B 2018, ' Different resuscitation strategies and novel pharmacologic treatment with valproic acid in traumatic brain injury ', Journal of Neuroscience Research, vol. 96, pp. 711-719 . https://doi.org/10.1002/jnr.24125

Traumatic brain injury (TBI) is a leading cause of death in young adults, and effective treatment strategies have the potential to save many lives. TBI results in coagulopathy, endothelial dysfunction, inflammation, cell death, and impaired epigeneti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bff634525c771c96897d0e60db459aff
https://doi.org/10.1002/jnr.24125

Zobrazit plný text záznamu

Early resuscitation with lyophilized plasma provides equal neuroprotection compared with fresh frozen plasma in a large animal survival model of traumatic brain injury and hemorrhagic shock

Autor: Patryk Piascik, Lisa Buckley, Hasan B. Alam, Ihab Halaweish, Patrick E. Georgoff, Ashok Srinivasan, Ted Bambakidis, Vahagn C. Nikolian, Peter J. Bruhn, Baoling Liu, Yongqing Li

Publikováno v: Journal of Trauma and Acute Care Surgery. 81:1080-1087

BACKGROUND Combined traumatic brain injury (TBI) and hemorrhagic shock (HS) is highly lethal. In previous models of combined TBI + HS, we showed that early resuscitation with fresh frozen plasma (FFP) improves neurologic outcomes. Delivering FFP, how

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b3ac53df6650f159c69ff299f21eca0
https://doi.org/10.1097/ta.0000000000001204

Zobrazit plný text záznamu

Resuscitation with Valproic Acid Alters Inflammatory Genes in a Porcine Model of Combined Traumatic Brain Injury and Hemorrhagic Shock

Autor: Yongqing Li, Guang Jin, Baoling Liu, Simone E. Dekker, Helga E. de Vries, Craig N. Johnson, Martin Sillesen, Hasan B. Alam, Ted Bambakidis

Publikováno v: Bambakidis, T, Dekker, S E, Sillesen, M, Liu, B, Johnson, C N, Jin, G, de Vries, H E, Li, Y & Alam, H B 2016, ' Resuscitation with Valproic Acid Alters Inflammatory Genes in a Porcine Model of Combined Traumatic Brain Injury and Hemorrhagic Shock ', Journal of Neurotrauma, vol. 33, no. 16, pp. 1514-1521 . https://doi.org/10.1089/neu.2015.4163
Journal of Neurotrauma, 33(16), 1514-1521. Mary Ann Liebert Inc.

Traumatic brain injury and hemorrhagic shock (TBI+HS) elicit a complex inflammatory response that contributes to secondary brain injury. There is currently no proven pharmacologic treatment for TBI+HS, but modulation of the epigenome has been shown t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::262c6271d20aded191a7c4b203b59124
https://doi.org/10.1089/neu.2015.4163

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání