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Autor:
Sasikumar Thavalakulamgar K, Andrew T. McPhail, Ruo Xu, Lynn A. Hyde, Ted Asberom, Wen-Lian Wu, Jing Su, Duane A. Burnett, Haiqun Tang, Josien Hubert B, Tom Bara, Lili Zhang, Hongmei Li, Martin S. Domalski, Li Qiang, Zhiqiang Zhao, Mckittrick Brian A, Dmitri A. Pissarnitski, William J. Greenlee, Murali Rajagopalan, Chad Bennett, David Cole, Mcbriar Mark D, John W. Clader
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(8)
A novel series of tricyclic gamma-secretase inhibitors was designed and synthesized via a conformational analysis of literature compounds. The preliminary results have shown that compounds in this new series have much improved in vitro potency and in