Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Ted, Powers"'
Autor:
Ted Powers
Publikováno v:
Molecular biology of the cell. 33(13)
METEI (Medical Expedition to Easter Island) was a Canadian-led expedition to Easter Island in 1964 that led to the discovery of rapamycin, launching a billion-dollar drug industry and major field of biomedical research.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4e05664c6de18cb1305f04b23620e53
https://pubmed.ncbi.nlm.nih.gov/36228182
https://pubmed.ncbi.nlm.nih.gov/36228182
Publikováno v:
Cell Reports, Vol 6, Iss 3, Pp 541-552 (2014)
Reactive oxygen species (ROS) are produced during normal metabolism and can function as signaling molecules. However, ROS at elevated levels can damage cells. Here, we identify the conserved target of rapamycin complex 2 (TORC2)/Ypk1 signaling module
Externí odkaz:
https://doaj.org/article/01322d26057843de8ae7209e6c6626b9
Publikováno v:
Molecular Biology of the Cell. 33
Two TOR kinase paralogues, TOR1 and TOR2, assemble preferentially into two complexes, TORC1 and TORC2. Chimeric TOR genes were constructed as a “sensitized” system for probing the importance of quaternary interactions in TORC2. This approach shou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a4e6e65ab133a34056ec005d6d95128
https://doi.org/10.1091/mbc.e21-12-0611
https://doi.org/10.1091/mbc.e21-12-0611
Publikováno v:
Biomolecules, Vol 8, Iss 2, p 36 (2018)
TOR is a serine/threonine protein kinase that assembles into distinct TOR Complexes 1 and 2 (TORC1 or TORC2) to regulate cell growth. In mammalian cells, a single mTOR incorporates stably into mTORC1 and mTORC2. By contrast, in Saccharomyces cerevisi
Externí odkaz:
https://doaj.org/article/389247e83b2d43e9ab94c2a6c45189ca
Autor:
Ted Powers, Judith Sims-Knight
Publikováno v:
2002 Annual Conference Proceedings.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45ed98691a8d93aca434f585ced4e8ef
https://doi.org/10.18260/1-2--11101
https://doi.org/10.18260/1-2--11101
Publikováno v:
Autophagy
Macroautophagy/autophagy is a starvation and stress-induced catabolic process critical for cellular homeostasis and adaptation. Several Atg proteins are involved in the formation of the autophagosome and subsequent degradation of cytoplasmic componen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfa989e48fa828828df267e4f73f1c56
https://doi.org/10.1080/15548627.2017.1356949
https://doi.org/10.1080/15548627.2017.1356949
Publikováno v:
The Journal of Cell Biology
Rapamycin-insensitive TORC2 signaling promotes amino acid starvation–induced autophagy through inhibition of the calcium-dependent phosphatase calcineurin. Vlahakis et al. show that this regulation requires the ER calcium channel regulatory protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ca6ed5283f0572c1a288bcedd2afecd
http://europepmc.org/articles/PMC5166500
http://europepmc.org/articles/PMC5166500
Autor:
Bobbiejane Stauffer, Ted Powers
Publikováno v:
Molecular Biology of the Cell
In response to endoplasmic reticulum (ER) stress, the yeast vacuole fragments into smaller vesicles. This process is independent of known ER stress pathways but requires TORC1 and its effectors, Sch9 and Tap42/Sit4. A genome-wide visual screen reveal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad8b7b49cf9cb7922ccd5c4ee28d50f9
https://doi.org/10.1091/mbc.e15-06-0344
https://doi.org/10.1091/mbc.e15-06-0344
Autor:
Abdel Aouacheria, Ted Powers, J. Marie Hardwick, Zdena Palková, Kyle W. Cunningham, Fedor F. Severin, Libuše Váchová
Publikováno v:
Science
Science, American Association for the Advancement of Science, 2018, 360 (6395), pp.eaar6910. ⟨10.1126/science.aar6910⟩
Science, 2018, 360 (6395), pp.eaar6910. ⟨10.1126/science.aar6910⟩
Science, American Association for the Advancement of Science, 2018, 360 (6395), pp.eaar6910. ⟨10.1126/science.aar6910⟩
Science, 2018, 360 (6395), pp.eaar6910. ⟨10.1126/science.aar6910⟩
Shlezinger et al . (Reports, 8 September 2017, p. 1037) report that the common fungus Aspergillus fumigatus , a cause of aspergillosis, undergoes caspase-dependent apoptosis-like cell death triggered by lung neutrophils. However, the technologies the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2fde7e2def3b8c1b4168c8f9a3ccc62
https://doi.org/10.1126/science.aar6910
https://doi.org/10.1126/science.aar6910