Zobrazeno 1 - 10
of 145
pro vyhledávání: '"Ted, Hackstadt"'
Publikováno v:
mBio, Vol 15, Iss 4 (2024)
ABSTRACTWe compared the growth characteristics of a virulent Rickettsia rickettsii strain (Sheila Smith) to an attenuated R. rickettsii stain (Iowa) and a non-pathogenic species (R. montanensis) in primary human dermal microvascular endothelial cells
Externí odkaz:
https://doaj.org/article/b8eab6ba58994574803e6b7baf3d91ad
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract The obligate intracellular bacterium, Chlamydia trachomatis, replicates within a parasitophorous vacuole termed an inclusion. During development, host proteins critical for regulating intracellular calcium (Ca2+) homeostasis interact with th
Externí odkaz:
https://doaj.org/article/945834735a464ec9b75c169079380bc9
Publikováno v:
mSphere, Vol 7, Iss 6 (2022)
ABSTRACT Mitochondria are critical cellular organelles that perform a wide variety of functions, including energy production and immune regulation. To perform these functions, mitochondria contain approximately 1,500 proteins, the majority of which a
Externí odkaz:
https://doaj.org/article/fdd2486840ce47888ed82035e9c1c2c8
Publikováno v:
mBio, Vol 13, Iss 2 (2022)
ABSTRACT The etiological agent of Rocky Mountain spotted fever, Rickettsia rickettsii, is an obligately intracellular pathogen that induces the polymerization of actin filaments to propel the bacterium through the cytoplasm and spread to new host cel
Externí odkaz:
https://doaj.org/article/82eed098b0d647768d326acafa0a7fe3
Publikováno v:
PLoS Pathogens, Vol 16, Iss 5, p e1008582 (2020)
Fragmentation of the Golgi apparatus is observed during a number of physiological processes including mitosis and apoptosis, but also occurs in pathological states such as neurodegenerative diseases and some infectious diseases. Here we show that hig
Externí odkaz:
https://doaj.org/article/f56d4fed26a146beabaffc390d479439
Autor:
Ted Hackstadt, Abhilash I. Chiramel, Forrest H. Hoyt, Brandi N. Williamson, Cheryl A. Dooley, Paul A. Beare, Emmie de Wit, Sonja M. Best, Elizabeth R. Fischer
Publikováno v:
Viruses, Vol 13, Iss 9, p 1798 (2021)
A variety of immunolabeling procedures for both light and electron microscopy were used to examine the cellular origins of the host membranes supporting the SARS-CoV-2 replication complex. The endoplasmic reticulum has long been implicated as a sourc
Externí odkaz:
https://doaj.org/article/da0bb646eddd4b82911ad4eb61c121bb
Autor:
Mary M. Weber, Jennifer L. Lam, Cheryl A. Dooley, Nicholas F. Noriea, Bryan T. Hansen, Forrest H. Hoyt, Aaron B. Carmody, Gail L. Sturdevant, Ted Hackstadt
Publikováno v:
Cell Reports, Vol 19, Iss 7, Pp 1406-1417 (2017)
Chlamydia trachomatis is a human pathogen associated with significant morbidity worldwide. As obligate intracellular parasites, chlamydiae must survive within eukaryotic cells for sufficient time to complete their developmental cycle. To promote host
Externí odkaz:
https://doaj.org/article/f5a3e4432a4a498695a12044bfce22e6
Autor:
Robert Faris, Marlena Merling, Shelby E. Andersen, Cheryl A. Dooley, Ted Hackstadt, Mary M. Weber
Publikováno v:
Cell Reports, Vol 26, Iss 12, Pp 3380-3390.e5 (2019)
Summary: Chlamydial infection requires the formation of a membrane-bound vacuole, termed the inclusion, that undergoes extensive interactions with select host organelles. The importance of the Inc protein CT229 in the formation and maintenance of the
Externí odkaz:
https://doaj.org/article/17e749f4e63d45f8b0ffe4c143627d07
Autor:
Stephanie S. Lehman, Nicholas F. Noriea, Karin Aistleitner, Tina R. Clark, Cheryl A. Dooley, Vinod Nair, Simran Jeet Kaur, M. Sayeedur Rahman, Joseph J. Gillespie, Abdu F. Azad, Ted Hackstadt
Publikováno v:
mBio, Vol 9, Iss 3 (2018)
ABSTRACT Strains of Rickettsia rickettsii, the tick-borne agent of Rocky Mountain spotted fever, vary considerably in virulence. Genomic comparisons of R. rickettsii strains have identified a relatively small number of genes divergent in an avirulent
Externí odkaz:
https://doaj.org/article/3a7f00d69f1140d1819f790ea553bb86
Publikováno v:
PLoS Pathogens, Vol 14, Iss 3, p e1006911 (2018)
Chlamydia trachomatis is an obligate intracellular bacterium that replicates within a vacuole termed an inclusion. At the end of their intracellular developmental cycle, chlamydiae are released either by lysis of the host cell or extrusion of the int
Externí odkaz:
https://doaj.org/article/88c96b023bcd4b179b2d60d8055a7f28