Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Techniques in genetics"'
Autor:
Francis J.A. Leblanc, Xuexin Jin, Kai Kang, Chang Jie Mick Lee, Juan Xu, Lina Xuan, Wenbo Ma, Hicham Belhaj, Marouane Benzaki, Neelam Mehta, Roger Sik Yin Foo, Svetlana Reilly, Chukwuemeka George Anene-Nzelu, Zhenwei Pan, Stanley Nattel, Baofeng Yang, Guillaume Lettre
Publikováno v:
iScience, Vol 27, Iss 9, Pp 110660- (2024)
Summary: Atrial fibrillation (AF) is the most common arrhythmia in the world. Human genetics can provide strong AF therapeutic candidates, but the identification of the causal genes and their functions remains challenging. Here, we applied an AF fine
Externí odkaz:
https://doaj.org/article/f281466b8091436bb93efc88b9330056
Autor:
Walther Parson, Christina Amory, Turi King, Michaela Preick, Cordula Berger, Anna König, Gabriela Huber, Katja Anslinger, Birgit Bayer, Gottfried Weichhold, Timo Sänger, Sabine Lutz-Bonengel, Heidi Pfeiffer, Michael Hofreiter, Dietmar Pfründer, Carsten Hohoff, Bernd Brinkmann
Publikováno v:
iScience, Vol 27, Iss 9, Pp 110539- (2024)
Summary: Kaspar Hauser’s parentage has been the subject of research and debate for nearly 200 years. As for his possible aristocratic descent through the House of Baden, there is suspicion that he was swapped as a baby, kidnapped, and kept in isola
Externí odkaz:
https://doaj.org/article/e1f47a2019ef40049b9968848d7ba746
Publikováno v:
iScience, Vol 27, Iss 9, Pp 110614- (2024)
Summary: In this study, we assessed the quality of de novo genome assemblies for three species of parasitic nematodes (Brugia malayi, Trichuris trichiura, and Ancylostoma caninum) generated using only Oxford Nanopore Technologies MinION data. Assembl
Externí odkaz:
https://doaj.org/article/c0481e7dbab541e3baf5bda2a6af6bf4
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110373- (2024)
Summary: Homologous recombination is initiated by the nucleolytic degradation (resection) of DNA double-strand breaks (DSBs). DSB resection is a two-step process. In the short-range step, the MRX (Mre11-Rad50-Xrs2) complex, together with Sae2, incise
Externí odkaz:
https://doaj.org/article/005a8cfcaad84c2196cb2a5f63050469
Autor:
Paul C. Lee, In-Hyuk Jung, Shreeya Thussu, Ved Patel, Ryan Wagoner, Kendall H. Burks, Junedh Amrute, Jared S. Elenbaas, Chul Joo Kang, Erica P. Young, Philipp E. Scherer, Nathan O. Stitziel
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110104- (2024)
Summary: Coronary artery disease (CAD) remains a leading cause of disease burden globally, and there is a persistent need for new therapeutic targets. Instrumental variable (IV) and genetic colocalization analyses can help identify novel therapeutic
Externí odkaz:
https://doaj.org/article/f1c5ae12bdf0423691d81d9943e37603
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109602- (2024)
Summary: It is a significant challenge to assess the functions of many uncharacterized genes in human malaria parasites. Here, we present a genetic screening tool to assess the contribution of essential genes from Plasmodium falciparum by the conditi
Externí odkaz:
https://doaj.org/article/bfa4d16cc4b84e758e80338abfbe8415
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109007- (2024)
Summary: Chromosomal instability (CIN) is a hallmark of cancers, and CIN-promoting mutations are not fully understood. Here, we report 141 chromosomal instability aiding variant (CIVa) candidates by assessing the prevalence of loss-of-function (LoF)
Externí odkaz:
https://doaj.org/article/1e0e32715fda4fc48c04d567eae83dec
Autor:
Meiying Bi, Mingkun Li, Jiaxun Wei, Ziwen Meng, Zhaoyang Wang, Ming Ying, Xiurong Yang, Lei Huang
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108983- (2024)
Summary: Rhizosphere dwelling microorganism such as Bacillus spp. are helpful for crop growth. However, these functions are adversely affected by long-term synthetic fertilizer application. We developed a modified CRISPR/Cas9 system using non-specifi
Externí odkaz:
https://doaj.org/article/f0d4d58079b34b859ec6950dbc3a1091
Autor:
Zifang Liu, Mary A. Kishe, Nestory P. Gabagambi, Asilatu H. Shechonge, Benjamin P. Ngatunga, Katie Smith, Andrew D. Saxon, Alan G. Hudson, Tyler Linderoth, George F. Turner, Rupert A. Collins, Martin J. Genner
Publikováno v:
iScience, Vol 27, Iss 1, Pp 108669- (2024)
Summary: There is considerable potential for nuclear genomic material in environmental DNA (eDNA) to inform us of population genetic structure within aquatic species. We tested if nuclear allelic composition data sourced from eDNA can resolve fine sc
Externí odkaz:
https://doaj.org/article/4062208fc4a84bf2ade03d01471fb1a9
Autor:
Romina J. Bevacqua, Weichen Zhao, Emilio Merheb, Seung Hyun Kim, Alexander Marson, Anna L. Gloyn, Seung K. Kim
Publikováno v:
iScience, Vol 27, Iss 1, Pp 108693- (2024)
Summary: Successful genome editing in primary human islets could reveal features of the genetic regulatory landscape underlying β cell function and diabetes risk. Here, we describe a CRISPR-based strategy to interrogate functions of predicted regula
Externí odkaz:
https://doaj.org/article/de99b45ae5104da68c614e2231a5ccff