Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Tebbe de Vries"'
Autor:
Georg Dorn, Christoph Gmeiner, Tebbe de Vries, Emil Dedic, Mihajlo Novakovic, Fred F. Damberger, Christophe Maris, Esteban Finol, Chris P. Sarnowski, Joachim Kohlbrecher, Timothy J. Welsh, Sreenath Bolisetty, Raffaele Mezzenga, Ruedi Aebersold, Alexander Leitner, Maxim Yulikov, Gunnar Jeschke, Frédéric H.-T. Allain
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract RNA-binding proteins (RBPs) are crucial regulators of gene expression, often composed of defined domains interspersed with flexible, intrinsically disordered regions. Determining the structure of ribonucleoprotein (RNP) complexes involving s
Externí odkaz:
https://doaj.org/article/6ecfd082137440199e61e0254d4f1997
Autor:
Anna Knörlein, Chris P. Sarnowski, Tebbe de Vries, Moritz Stoltz, Michael Götze, Ruedi Aebersold, Frédéric H.-T. Allain, Alexander Leitner, Jonathan Hall
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Although UV-induced cross-linking is a widely used method to study RNA-protein complexes, the cross-linking reactions are poorly understood. Here, the authors show that π-stacking interactions between nucleobases and aromatic amino acids play a key
Externí odkaz:
https://doaj.org/article/2cd6d485f0bf4ae2b1dfd7988cfbb5cd
Autor:
Alexander Leitner, Frédéric H.-T. Allain, Michael Götze, Anna Knörlein, Jonathan Hall, Chris P. Sarnowski, Ruedi Aebersold, Tebbe de Vries
Publikováno v:
Analytical Chemistry, 93 (44)
Analytical Chemistry
Analytical Chemistry
RNA-protein interactions mediate many intracellular processes. CLIR-MS (cross-linking of isotope-labeled RNA and tandem mass spectrometry) allows the identification of RNA-protein interaction sites at single nucleotide/amino acid resolution in a sing
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2537
Alternative RNA splicing is an essential part of gene expression that not only increases the protein diversity of metazoan but also provides an additional layer of gene expression regulation. The U1 small ribonucleoparticle (U1 snRNP) plays an essent
Autor:
Tebbe de Vries, William Martelly, Sébastien Campagne, Kevin Sabath, Chris P. Sarnowski, Jason Wong, Alexander Leitner, Stefanie Jonas, Shalini Sharma, Frédéric H.-T. Allain
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 119 (6)
In mammals, the structural basis for the interaction between U1 and U2 small nuclear ribonucleoproteins (snRNPs) during the early steps of splicing is still elusive. The binding of the ubiquitin-like (UBL) domain of SF3A1 to the stem-loop 4 of U1 snR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e958e5739e8aa46d74e94134e00ae7e5
https://hdl.handle.net/20.500.11850/532091
https://hdl.handle.net/20.500.11850/532091
Publikováno v:
Methods in Molecular Biology ISBN: 9781071625200
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57bf641b25e04aa75baeeb52ff32e95e
https://doi.org/10.1007/978-1-0716-2521-7_15
https://doi.org/10.1007/978-1-0716-2521-7_15
Autor:
Ruedi Aebersold, Tebbe de Vries, Anna Knörlein, Jonathan Hall, Alexander Leitner, Frédéric H.-T. Allain, Moritz Stoltz, Chris P. Sarnowski, Michael Götze
Understanding structure-function relationships of RNA-binding proteins requires knowledge of how they bind RNAs in vivo. RNA-protein interactions are studied using light-induced cross-linking at “zero-distance”, yielding nucleotide/amino-acid add
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8eb9446c60573010d39ab422b135e32
https://doi.org/10.26434/chemrxiv-2021-05zhj
https://doi.org/10.26434/chemrxiv-2021-05zhj
Autor:
Gunnar Jeschke, Frédéric H.-T. Allain, Fred F. Damberger, Maxim Yulikov, Cristina K. X. Nguyen, Enrico Klotzsch, Luis Fábregas Ibáñez, Simon Mergenthal, Laura Esteban-Hofer, Tebbe de Vries, Leonidas Emmanouilidis
Publikováno v:
Nature chemical biology. 17(5)
Many RNA-binding proteins undergo liquid-liquid phase separation, which underlies the formation of membraneless organelles, such as stress granules and P-bodies. Studies of the molecular mechanism of phase separation in vitro are hampered by the coal
Autor:
Antoine Cléry, Sébastien Campagne, Frédéric H.-T. Allain, Pavel Afanasyev, Daniel Boehringer, Emil Dedic, Georg Dorn, Joachim Kohlbrecher, Florian Malard, Tebbe de Vries
Publikováno v:
Nucleic Acids Research
U1 small nuclear ribonucleoparticle (U1 snRNP) plays a central role during RNA processing. Previous structures of U1 snRNP revealed how the ribonucleoparticle is organized and recognizes the pre-mRNA substrate at the exon–intron junction. As with m