Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Tea Lund Laursen"'
Autor:
Ditte Emilie Munk, Tea Lund Laursen, Frederik Teicher Kirk, Hendrik Vilstrup, Aftab Ala, Lars Christian Gormsen, Peter Ott, Thomas Damgaard Sandahl
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Zinc inhibits intestinal copper uptake, an effect utilized for treating Wilson’s disease (WD). We used copper-64 (64Cu) PET/CT to examine how much four weeks of treatment with different zinc regimens reduced the hepatic 64Cu content after
Externí odkaz:
https://doaj.org/article/2e7e1fd3793649e4ac2dd3acc0061b69
Publikováno v:
Journal of Clinical Medicine, Vol 11, Iss 9, p 2271 (2022)
Data concerning non-invasive discrimination of simple steatosis from steatohepatitis in metabolic-associated fatty liver disease (MAFLD) and risk of disease progression in patients with MAFLD are conflicting. We aimed to investigate these factors in
Externí odkaz:
https://doaj.org/article/55b85c0ab1814109a160a35025bb9173
Autor:
Jessica Björklund, Tea Lund Laursen, Thomas Damgaard Sandahl, Holger Jon Møller, Hendrik Vilstrup, Peter Ott, Henning Grønbæk
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 13, Iss 1, Pp 1-6 (2018)
Abstract Background Hepatic macrophage (Kupffer cell) hyperplasia is often described in Wilson’s disease (WD). In many liver diseases, Kupffer cell activation is related to disease severity, liver function, and fibrosis but the importance in WD is
Externí odkaz:
https://doaj.org/article/73ce50f80ce54017a12d6480fbca1dfe
Autor:
Rasmus Hvidbjerg Gantzel, Mikkel Breinholt Kjær, Tea Lund Laursen, Konstantin Kazankov, Jacob George, Holger Jon Møller, Henning Grønbæk
Publikováno v:
Frontiers in Medicine, Vol 7 (2021)
Macrophages are essential components of the human host immune system, which upon activation facilitates a broad pallet of immunomodulatory events including release of pro- or anti-inflammatory cytokines and chemokines, restoration of immune homeostas
Externí odkaz:
https://doaj.org/article/bd5c49cf504f48feb260b58fdb01538b
Autor:
Lotte Lindgreen Eriksen, Morten Aagaard Nielsen, Tea Lund Laursen, Bent Deleuran, Hendrik Vilstrup, Sidsel Støy
Publikováno v:
PLoS ONE, Vol 16, Iss 8 (2021)
Objectives In alcoholic hepatitis (AH), dysfunctional T lymphocytes may contribute to the high mortality from infections. T lymphocyte activation is governed by the expression of co-stimulatory receptors such as 4-1BB balanced by inhibitory receptors
Externí odkaz:
https://doaj.org/article/9ba21ce7cf9448e1b348919ed3c1740a
Autor:
Thomas Damgaard Sandahl, Sidsel Hyldgaard Støy, Tea Lund Laursen, Sidsel Rødgaard-Hansen, Holger Jon Møller, Søren Møller, Hendrik Vilstrup, Henning Grønbæk
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0189345 (2017)
Hepatic macrophages (Kupffer cells) are involved in the immunopathology of alcoholic liver disease (ALD). The mannose receptor (MR, CD206), expressed primarily by macrophages, mediates endocytosis, antigen presentation and T-cell activation. A solubl
Externí odkaz:
https://doaj.org/article/8e6ef5e9a1a044ebadd56fbdf2c8b705
Publikováno v:
Laursen, T L, Mellemkjær, A, Møller, H J, Grønbæk, H & Kazankov, K 2022, ' Spotlight on liver macrophages for halting injury and progression in non-alcoholic fatty liver disease ', Expert Opinion On Therapeutic Targets, vol. 26, no. 8, pp. 697-705 . https://doi.org/10.1080/14728222.2022.2132145
INTRODUCTION: Non-alcoholic fatty liver disease (NAFLD) is considered the hepatic manifestation of the metabolic syndrome and is rapidly emerging as the leading cause of liver-related morbidity and mortality. Macrophages play an essential role in the
Autor:
Tea Lund Laursen, Lars Bossen, Rasmus Pihl, Anne Troldborg, Thomas Damgaard Sandahl, Annette Gudmann Hansen, Trine Folserass, Mette Vesterhus, Henning Grønbæk, Steffen Thiel
Publikováno v:
Laursen, T L, Bossen, L, Pihl, R, Troldborg, A, Sandahl, T D, Hansen, A G, Folserass, T, Vesterhus, M, Gronbaek, H & Thiel, S 2022, ' Highly Increased Levels of Inter-α-inhibitor Heavy Chain 4 (ITIH4) in Autoimmune Cholestatic Liver Diseases ', Journal of clinical and translational hepatology, vol. 10, no. 5, pp. 796–802 . https://doi.org/10.14218/JCTH.2021.00515
Laursen, T L, Bossen, L, Pihl, R, Troldborg, A, Sandahl, T D, Hansen, A G, Folserass, T, Vesterhus, M, Grønbæk, H & Thiel, S 2022, ' Highly Increased Levels of Inter-α-inhibitor Heavy Chain 4 (ITIH4) in Autoimmune Cholestatic Liver Diseases ', Journal of clinical and translational hepatology, vol. 10, no. 5, pp. 796-802 . https://doi.org/10.14218/JCTH.2021.00515
Laursen, T L, Bossen, L, Pihl, R, Troldborg, A, Sandahl, T D, Hansen, A G, Folserass, T, Vesterhus, M, Grønbæk, H & Thiel, S 2022, ' Highly Increased Levels of Inter-α-inhibitor Heavy Chain 4 (ITIH4) in Autoimmune Cholestatic Liver Diseases ', Journal of clinical and translational hepatology, vol. 10, no. 5, pp. 796-802 . https://doi.org/10.14218/JCTH.2021.00515
Background and Aims: There is an unmet need for new biomarkers to improve diagnostics and prognostics in primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC). Inter-α-inhibitor heavy chain 4 (ITIH4) is an abundant, liver-produc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66afbbf2675da9f8bc3c324ddf67cc0b
https://pure.au.dk/portal/da/publications/highly-increased-levels-of-interinhibitor-heavy-chain-4-itih4-in-autoimmune-cholestatic-liver-diseases(49858c08-7851-49f5-b4a4-bec9b387191c).html
https://pure.au.dk/portal/da/publications/highly-increased-levels-of-interinhibitor-heavy-chain-4-itih4-in-autoimmune-cholestatic-liver-diseases(49858c08-7851-49f5-b4a4-bec9b387191c).html
Autor:
Michelle Møhlenberg, Peter Lykke Eriksen, Tea Lund Laursen, Mette Bak Nielsen, Stephen Jacques Hamilton Dutoit, Henning Grønbæk, Rune Hartmann, Karen Louise Thomsen
Publikováno v:
Møhlenberg, M, Eriksen, P L, Laursen, T L, Nielsen, M B, Hamilton-Dutoit, S J, Grønbæk, H, Hartmann, R & Thomsen, K L 2022, ' The presence of interferon affects the progression of non-alcoholic fatty liver disease ', Genes and Immunity, vol. 23, no. 5, pp. 157–165 . https://doi.org/10.1038/s41435-022-00176-6
Inflammation and metabolic dysfunction are hallmarks of the progression of non-alcoholic fatty liver disease (NAFLD), which is the fastest-growing liver disease worldwide. Emerging evidence indicates that innate immune mechanisms are essential driver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e5212ef9ec61f8f3d2e88ebe0894f0b
https://pure.au.dk/portal/da/publications/the-presence-of-interferon-affects-the-progression-of-nonalcoholic-fatty-liver-disease(bdc6285f-2b0a-4fb2-bc61-d4d82f9305d6).html
https://pure.au.dk/portal/da/publications/the-presence-of-interferon-affects-the-progression-of-nonalcoholic-fatty-liver-disease(bdc6285f-2b0a-4fb2-bc61-d4d82f9305d6).html
Autor:
Ditte Emilie Munk, Tea Lund Laursen, Frederik Teicher Kirk, Hendrik Vilstrup, Aftab Ala, Lars Christian Gormsen, Peter Ott, Thomas Damgaard Sandahl
Publikováno v:
Munk, D E, Lund Laursen, T, Teicher Kirk, F, Vilstrup, H, Ala, A, Gormsen, L C, Ott, P & Damgaard Sandahl, T 2022, ' Effect of oral zinc regimens on human hepatic copper content : a randomized intervention study ', Scientific Reports, vol. 12, no. 1, 14714 . https://doi.org/10.1038/s41598-022-18872-8
Zinc inhibits intestinal copper uptake, an effect utilized for treating Wilson’s disease (WD). We used copper-64 (64Cu) PET/CT to examine how much four weeks of treatment with different zinc regimens reduced the hepatic 64Cu content after oral 64Cu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1a4f570f2adac8808e9c4bfe88c0ea8
https://pure.au.dk/portal/da/publications/effect-of-oral-zinc-regimens-on-human-hepatic-copper-content(5fe5f2e6-0e2a-485d-a644-b58d0d928e14).html
https://pure.au.dk/portal/da/publications/effect-of-oral-zinc-regimens-on-human-hepatic-copper-content(5fe5f2e6-0e2a-485d-a644-b58d0d928e14).html