Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Tea Gogishvili"'
Autor:
Agnes Banaszek, Thomas G. P. Bumm, Boris Nowotny, Maria Geis, Kim Jacob, Matthias Wölfl, Johannes Trebing, Kirstin Kucka, Dina Kouhestani, Tea Gogishvili, Bastian Krenz, Justina Lutz, Leo Rasche, Dirk Hönemann, Hannes Neuweiler, Julia C. Heiby, Ralf C. Bargou, Harald Wajant, Hermann Einsele, Gert Riethmüller, Gernot Stuhler
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
The restriction of appropriate tumour-specific antigens is a current limitation for T cell-engaging immunotherapy. Here, the authors have designed a new system constituted by two halve antibodies, which engage T cells once binding to two different an
Externí odkaz:
https://doaj.org/article/2c0baf0c95d243a58f06fcb336d652c2
Autor:
Sophia Danhof, Martin Schreder, Stefan Knop, Leo Rasche, Susanne Strifler, Claudia Löffler, Tea Gogishvili, Hermann Einsele, Michael Hudecek
Publikováno v:
Haematologica, Vol 103, Iss 3 (2018)
Externí odkaz:
https://doaj.org/article/40305e8c9d0244548239a44a1e7b0d15
Autor:
Daniela Langenhorst, Tea Gogishvili, Eliana Ribechini, Susanne Kneitz, Kirsty McPherson, Manfred B Lutz, Thomas Hünig
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e50080 (2012)
The ability of CD4(+)Foxp3(+) regulatory T-cells (Treg) to produce interleukin (IL)-10 is important for the limitation of inflammation at environmental interfaces like colon or lung. Under steady state conditions, however, few Tregs produce IL-10 ex
Externí odkaz:
https://doaj.org/article/f7a2af6b1c8f4353bd0e24cac9e33fbf
Autor:
Tea Gogishvili, Daniela Langenhorst, Fred Lühder, Fernando Elias, Karin Elflein, Kevin M Dennehy, Ralf Gold, Thomas Hünig
Publikováno v:
PLoS ONE, Vol 4, Iss 2, p e4643 (2009)
Superagonistic CD28-specific monoclonal antibodies (CD28SA) are highly effective activators of regulatory T-cells (Treg cells) in rats, but a first-in-man trial of the human CD28SA TGN1412 resulted in an unexpected cytokine release syndrome. Using a
Externí odkaz:
https://doaj.org/article/73967c47d22441d8b9794e66560be981
Autor:
Martin Vaeth, Marco A. Ataide, Justus Weber, Hao Wu, Georg Gasteiger, Axel Kallies, Wolfgang Kastenmüller, Sarah Eickhoff, Anika Grafen, Natalio Garbi, Michael Hölzel, Tea Gogishvili, Hermann Einsele, Konrad Knöpper, Michael Hudecek, Karl Komander, Annika E. Peters
Publikováno v:
Nature Immunology
Antiviral CD8+ T cell responses are characterized by an initial activation/priming of T lymphocytes followed by a massive proliferation, subset differentiation, population contraction and the development of a stable memory pool. The transcription fac
Autor:
Ralf C. Bargou, Gert Riethmüller, Kim Jacob, Matthias Wölfl, Thomas Bumm, Gernot Stuhler, Hermann Einsele, Maria Geis, Dina Kouhestani, Julia C. Heiby, Leo Rasche, Johannes Trebing, Tea Gogishvili, Boris Nowotny, Justina Lutz, Harald Wajant, Dirk Hönemann, Bastian Krenz, Hannes Neuweiler, Kirstin Kucka, Agnes Banaszek
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Nature Communications
Nature Communications
T cell-engaging immunotherapies are changing the landscape of current cancer care. However, suitable target antigens are scarce, restricting these strategies to very few tumor types. Here, we report on a T cell-engaging antibody derivative that comes
Autor:
Marco A, Ataide, Karl, Komander, Konrad, Knöpper, Annika E, Peters, Hao, Wu, Sarah, Eickhoff, Tea, Gogishvili, Justus, Weber, Anika, Grafen, Axel, Kallies, Natalio, Garbi, Hermann, Einsele, Michael, Hudecek, Georg, Gasteiger, Michael, Hölzel, Martin, Vaeth, Wolfgang, Kastenmüller
Publikováno v:
Nature immunology. 21(11)
Antiviral CD8
Autor:
Christian Brede, Sophia Danhof, Tea Gogishvili, Julian Rydzek, Michael Hudecek, Hermann Einsele, Sabrina Prommersberger, Martin Schreder
Publikováno v:
Blood. 130:2838-2847
SLAMF7 is under intense investigation as a target for immunotherapy in multiple myeloma. In this study, we redirected the specificity of T cells to SLAMF7 through expression of a chimeric antigen receptor (CAR) derived from the huLuc63 antibody (elot
Autor:
Susanne Strifler, Leo Rasche, Claudia Löffler, Stefan Knop, Tea Gogishvili, Michael Hudecek, Martin Schreder, Hermann Einsele, Sophia Danhof
Publikováno v:
Haematologica. 103(3)
Autor:
Michael Hudecek, Tea Gogishvili, David G. Maloney, Daniel Sommermeyer, Cameron J. Turtle, Stanley R. Riddell, Paula L. Kosasih
Publikováno v:
Leukemia
Adoptive T-cell therapy with gene-modified T cells expressing a tumor-reactive T-cell receptor or chimeric antigen receptor (CAR) is a rapidly growing field of translational medicine and has shown success in the treatment of B-cell malignancies and s