Zobrazeno 1 - 10
of 260
pro vyhledávání: '"Tdp1 inhibitor"'
Autor:
Dyrkheeva, Nadezhda S.1 (AUTHOR), Malakhova, Anastasia A.1,2 (AUTHOR), Zakharenko, Aleksandra L.1 (AUTHOR), Okorokova, Larisa S.3 (AUTHOR), Shtokalo, Dmitriy N.3,4 (AUTHOR), Pavlova, Sophia V.1,2 (AUTHOR), Medvedev, Sergey P.1,2 (AUTHOR), Zakian, Suren M.1,2 (AUTHOR), Nushtaeva, Anna A.1 (AUTHOR), Tupikin, Alexey E.1 (AUTHOR), Kabilov, Marsel R.1 (AUTHOR), Khodyreva, Svetlana N.1 (AUTHOR), Luzina, Olga A.5 (AUTHOR) luzina@nioch.nsc.ru, Salakhutdinov, Nariman F.5 (AUTHOR), Lavrik, Olga I.1,6 (AUTHOR)
Publikováno v:
International Journal of Molecular Sciences. Mar2023, Vol. 24 Issue 6, p5148. 21p.
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Dean, Richard A. **, Fam, Hok Khim **, An, Jianghong, Choi, Kunho, Shimizu, Yoko, Jones, Steven J.M., Boerkoel, Cornelius F., Interthal, Heidrun, Pfeifer, Tom A. *
Publikováno v:
In SLAS Discovery December 2014 19(10):1372-1382
Autor:
Nadezhda S. Dyrkheeva, Anastasia A. Malakhova, Aleksandra L. Zakharenko, Larisa S. Okorokova, Dmitriy N. Shtokalo, Sophia V. Pavlova, Sergey P. Medvedev, Suren M. Zakian, Anna A. Nushtaeva, Alexey E. Tupikin, Marsel R. Kabilov, Svetlana N. Khodyreva, Olga A. Luzina, Nariman F. Salakhutdinov, Olga I. Lavrik
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 6; Pages: 5148
Topoisomerase 1 (TOP1) is an enzyme that regulates DNA topology and is essential for replication, recombination, and other processes. The normal TOP1 catalytic cycle involves the formation of a short-lived covalent complex with the 3′ end of DNA (T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dff247c50c88d5f3afcf93d39f67a62a
https://doi.org/10.3390/ijms24065148
https://doi.org/10.3390/ijms24065148
Autor:
Chepanova, A. A.1 (AUTHOR), Zakharenko, A. L.1 (AUTHOR), Dyrkheeva, N. S.1 (AUTHOR), Chernyshova, I. A.1 (AUTHOR), Zakharova, O. D.1 (AUTHOR), Ilina, E. S.1 (AUTHOR), Luzina, O. A.2 (AUTHOR), Salakhutdinov, N. F.2 (AUTHOR), Lavrik, O. I.1 (AUTHOR) lavrik@niboch.nsc.ru
Publikováno v:
Doklady Biochemistry & Biophysics. Feb2023, Vol. 508 Issue 1, p25-30. 6p.
Autor:
Jianghong An, Yoko Shimizu, Tom A. Pfeifer, Hok Khim Fam, Cornelius F. Boerkoel, Kunho Choi, Richard A. Dean, Heidrun Interthal, Steven J.M. Jones
Publikováno v:
SLAS Discovery. 19:1372-1382
Mutations of DNA repair pathways contribute to tumorigenesis and provide a therapeutic target for synthetic lethal interactions in tumor cells. Given that tyrosyl-DNA phosphodiesterase 1 (Tdp1) repairs stalled topoisomerase-I DNA complexes, we hypoth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::596166f3c865d45417f928daf8b05d84
https://doi.org/10.1177/1087057114546551
https://doi.org/10.1177/1087057114546551
Autor:
Oksana V. Salomatina, Tatyana E. Kornienko, Alexandra L. Zakharenko, Nina I. Komarova, Chigozie Achara, Jóhannes Reynisson, Nariman F. Salakhutdinov, Olga I. Lavrik, Konstantin P. Volcho
Publikováno v:
Molecules, Vol 29, Iss 3, p 581 (2024)
Deoxycholic acid derivatives containing various heterocyclic functional groups at C-3 on the steroid scaffold were designed and synthesized as promising dual tyrosyl-DNA phosphodiesterase 1 and 2 (TDP1 and TDP2) inhibitors, which are potential target
Externí odkaz:
https://doaj.org/article/f7a6940d786f428597863fdfcc30635e
Publikováno v:
Drug Week; 4/14/2023, p2777-2777, 1p
Autor:
Dyrkheeva, N. S., Zakharenko, A. L., Novoselova, E. S., Chepanova, A. A., Popova, N. A., Nikolin, V. P., Luzina, O. A., Salakhutdinov, N. F., Ryabchikova, E. I., Lavrik, O. I.
Publikováno v:
Molecular Biology; Mar2021, Vol. 55 Issue 2, p273-277, 5p
Autor:
Irina A. Chernyshova, Aleksandra L. Zakharenko, Nikolay N. Kurochkin, Nadezhda S. Dyrkheeva, Tatyana E. Kornienko, Nelly A. Popova, Valeriy P. Nikolin, Ekaterina S. Ilina, Timofey D. Zharkov, Maxim S. Kupryushkin, Vladimir E. Oslovsky, Mikhail S. Drenichev, Olga I. Lavrik
Publikováno v:
Molecules, Vol 28, Iss 1, p 323 (2022)
The use of cancer chemotherapy sensitizers is a promising approach to induce the effect of clinically used anticancer treatments. One of the interesting targets is Tyrosyl-DNA Phosphodiesterase 1 (Tdp1), a DNA-repair enzyme, that may prevent the acti
Externí odkaz:
https://doaj.org/article/1bed77c2f7a94878b8b6b1122def7fc2