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The Age-Driven Decline in Neutrophil Function Contributes to the Reduced Efficacy of the Pneumococcal Conjugate Vaccine in Old Hosts

Autor: Simmons, Shaunna R., Tchalla, Essi Y. I., Bhalla, Manmeet, Bou Ghanem, Elsa N.

Publikováno v: Frontiers in cellular and infection microbiology. 12

Despite the availability of vaccines, Streptococcus pneumoniae (pneumococcus) remains a serious cause of infections in the elderly. The efficacy of anti-pneumococcal vaccines declines with age. While age-driven changes in antibody responses are well

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::875106c903a9cbfde9f9e0d0f0c8aba3
https://pubmed.ncbi.nlm.nih.gov/35402289

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Activating A1 adenosine receptor signaling boosts early pulmonary neutrophil recruitment in aged mice in response to Streptococcus pneumoniae infection.

Autor: Simmons SR; Department of Microbiology and Immunology, School of Medicine, University at Buffalo, Buffalo, NY, USA., Herring SE; Department of Microbiology and Immunology, School of Medicine, University at Buffalo, Buffalo, NY, USA., Tchalla EYI; Department of Microbiology and Immunology, School of Medicine, University at Buffalo, Buffalo, NY, USA., Lenhard AP; Department of Microbiology and Immunology, School of Medicine, University at Buffalo, Buffalo, NY, USA., Bhalla M; Department of Microbiology and Immunology, School of Medicine, University at Buffalo, Buffalo, NY, USA., Bou Ghanem EN; Department of Microbiology and Immunology, School of Medicine, University at Buffalo, Buffalo, NY, USA. Elsaboug@buffalo.edu.

Publikováno v: Immunity & ageing : I & A [Immun Ageing] 2024 Jun 05; Vol. 21 (1), pp. 34. Date of Electronic Publication: 2024 Jun 05.