A3.06 Distinct expression pattern of peripheral tissue-restricted antigens in human LYMPH node stromal cells during the earliest phases of rheumatoid arthritis

Autor: TH Ramwadhdoebe, K.P. van Lienden, Tbh Geijtenbeek, J Hähnlein, Paul P. Tak, Lgm van Baarsen, M. Maas, JF Semmelink, M Safy, Danielle M. Gerlag

Publikováno v: Annals of the Rheumatic Diseases. 75:A34.2-A35

Background In mice lymph node stromal cells (LNSCs) maintain peripheral tolerance through the presentation of peripheral tissue-restricted antigens (PTAs) and negative regulation of T-cells. However, little is known about PTA expression in human LNSC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ad62ffa3d5f0959ea189e68e63e11ea3
https://doi.org/10.1136/annrheumdis-2016-209124.83

O13.4 Cervicovaginal microbiome dysbiosis is associated with proteome changes related to alterations of the cervicovaginal mucosal barrier

Autor: Raju Gautam, Jonathan M. Wastling, Gilles Ndayisaba, Hanneke Borgdorff, N H van Teijlingen, Jhhm van de Wijgert, Dong Xia, Tbh Geijtenbeek, Stuart D. Armstrong

Publikováno v: Sexually Transmitted Infections. 91:A54.1-A54

Introduction Vaginal microbiome (VMB) dysbiosis is associated with increased acquisition of HIV and sexually transmitted infections (STIs). Cervicovaginal inflammation and other changes to the mucosal barrier are thought to play important roles but h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d03614db64dbfa344297580f01aaa4e9
https://doi.org/10.1136/sextrans-2015-052270.150

FRI0353 Human Lymph Node Stromal Cells Obtained from Rheumatoid Arthritis Patients as Well as from Healthy Individuals Express the Autoimmune Regulator Aire

Autor: L G M van Baarsen, Tbh Geijtenbeek, IY Choi, M. Maas, Paul P. Tak, TH Ramwadhdoebe, Ferco H. Berger, Nam Smits, J Hähnlein, H.F. Semmelink, KI Maijer, Danielle M. Gerlag

Publikováno v: Annals of the Rheumatic Diseases. 73:515.1-515

Background Rheumatoid arthritis (RA) is an autoimmune disease with unknown etiology. Immune activation in peripheral lymphoid tissues seems to precede synovial tissue inflammation. The stromal compartment of lymph nodes is crucial for the induction a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::066c1054afbdee64153bfb3254e800f3
https://doi.org/10.1136/annrheumdis-2014-eular.5396

Energy demanding RNA and protein metabolism drive dysfunctionality of HIV-specific T cell changes during chronic HIV infection.

Autor: van Pul L; Amsterdam UMC location University of Amsterdam, Laboratory for Viral Immune Pathogenesis, Amsterdam, The Netherlands.; Amsterdam UMC location University of Amsterdam, Department of Experimental Immunology, Amsterdam, The Netherlands.; Amsterdam Institute for Infection and Immunity, Amsterdam, The Netherlands., Stunnenberg M; Amsterdam UMC location University of Amsterdam, Department of Experimental Immunology, Amsterdam, The Netherlands.; Amsterdam Institute for Infection and Immunity, Amsterdam, The Netherlands., Kroeze S; Amsterdam UMC location University of Amsterdam, Laboratory for Viral Immune Pathogenesis, Amsterdam, The Netherlands.; Amsterdam UMC location University of Amsterdam, Department of Experimental Immunology, Amsterdam, The Netherlands.; Amsterdam Institute for Infection and Immunity, Amsterdam, The Netherlands., van Dort KA; Amsterdam UMC location University of Amsterdam, Laboratory for Viral Immune Pathogenesis, Amsterdam, The Netherlands.; Amsterdam UMC location University of Amsterdam, Department of Experimental Immunology, Amsterdam, The Netherlands.; Amsterdam Institute for Infection and Immunity, Amsterdam, The Netherlands., Boeser-Nunnink BDM; Amsterdam UMC location University of Amsterdam, Laboratory for Viral Immune Pathogenesis, Amsterdam, The Netherlands.; Amsterdam UMC location University of Amsterdam, Department of Experimental Immunology, Amsterdam, The Netherlands.; Amsterdam Institute for Infection and Immunity, Amsterdam, The Netherlands., Harskamp AM; Amsterdam UMC location University of Amsterdam, Laboratory for Viral Immune Pathogenesis, Amsterdam, The Netherlands.; Amsterdam UMC location University of Amsterdam, Department of Experimental Immunology, Amsterdam, The Netherlands.; Amsterdam Institute for Infection and Immunity, Amsterdam, The Netherlands., Geijtenbeek TBH; Amsterdam UMC location University of Amsterdam, Department of Experimental Immunology, Amsterdam, The Netherlands.; Amsterdam Institute for Infection and Immunity, Amsterdam, The Netherlands., Kootstra NA; Amsterdam UMC location University of Amsterdam, Laboratory for Viral Immune Pathogenesis, Amsterdam, The Netherlands.; Amsterdam UMC location University of Amsterdam, Department of Experimental Immunology, Amsterdam, The Netherlands.; Amsterdam Institute for Infection and Immunity, Amsterdam, The Netherlands.

Publikováno v: PloS one [PLoS One] 2024 Oct 02; Vol. 19 (10), pp. e0298472. Date of Electronic Publication: 2024 Oct 02 (Print Publication: 2024).

Human CD127 negative ILC2s show immunological memory.

Autor: Mathä L; Microbiology, Tumor and Cell Biology, Karolinska Institute , Stockholm, Sweden.; Terry Fox Laboratory, British Columbia Cancer , Vancouver, Canada., Krabbendam L; Department of Experimental Immunology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands.; Department of Pulmonary Medicine, Erasmus Medical Center, University of Rotterdam, Rotterdam, Netherlands., Martinez Høyer S; Microbiology, Tumor and Cell Biology, Karolinska Institute , Stockholm, Sweden., Heesters BA; Department of Experimental Immunology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands.; Chemical Biology and Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands., Golebski K; Department of Experimental Immunology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands.; Department of Pulmonary Medicine, Amsterdam University Medical Center, Amsterdam, Netherlands., Kradolfer C; Department of Experimental Immunology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands., Ghaedi M; Terry Fox Laboratory, British Columbia Cancer , Vancouver, Canada.; Princess Margaret Cancer Centre, University Health Network , Toronto, Canada., Ma J; Microbiology, Tumor and Cell Biology, Karolinska Institute , Stockholm, Sweden., Stadhouders R; Department of Pulmonary Medicine, Erasmus Medical Center, University of Rotterdam, Rotterdam, Netherlands., Bachert C; Department of Oto-Rhino-Laryngology, Münster University, Münster, Germany.; Sun Yat-sen University, The First Affiliated Hospital , Guangzhou, China.; Upper Airway Research Laboratory, Ghent University , Ghent, Belgium.; ENT-Department, Karolinska University Hospital , Stockholm, Sweden.; Department of Otorhinolaryngology, Karolinska University Hospital, Stockholm, Sweden., Cardell LO; ENT-Department, Karolinska University Hospital , Stockholm, Sweden., Zhang N; Upper Airway Research Laboratory, Ghent University , Ghent, Belgium., Holtappels G; Upper Airway Research Laboratory, Ghent University , Ghent, Belgium., Reitsma S; Department of Otorhinolaryngology and Head/Neck Surgery, University of Amsterdam, Amsterdam University Medical Center, Amsterdam, Netherlands., Helgers LC; Department of Experimental Immunology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands.; Amsterdam Institute for Infection & Immunity, Amsterdam University Medical Center, University of Amsterdam , Amsterdam, Netherlands., Geijtenbeek TBH; Department of Experimental Immunology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands.; Amsterdam Institute for Infection & Immunity, Amsterdam University Medical Center, University of Amsterdam , Amsterdam, Netherlands., Coquet JM; Microbiology, Tumor and Cell Biology, Karolinska Institute , Stockholm, Sweden., Takei F; Terry Fox Laboratory, British Columbia Cancer , Vancouver, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada., Spits H; Department of Experimental Immunology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands., Martinez-Gonzalez I; Microbiology, Tumor and Cell Biology, Karolinska Institute , Stockholm, Sweden.; Department of Experimental Immunology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands.

Publikováno v: The Journal of experimental medicine [J Exp Med] 2024 Aug 05; Vol. 221 (8). Date of Electronic Publication: 2024 Jun 18.