Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Tazuko H Hirai"'
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0191033 (2018)
Substantial evidence has accumulated linking epigenome change to alterations in stem cell function during postnatal development and aging. Yet much remains to be learned about causal relationships, and large gaps remain in our understanding of epigen
Externí odkaz:
https://doaj.org/article/dd1433e54cdb447d873a56e6b959fd7e
Autor:
Valya R. Russanova, Thomae G. Sourlingas, Roberto Romero, Jonathan I. Epstein, Kalliope E. Sekeri-Pataryas, Paraskevi Salpea, Bruce H. Howard, Tazuko H. Hirai
Publikováno v:
Nucleic Acids Research
Alterations in DNA methylation have been reported to occur during development and aging; however, much remains to be learned regarding post-natal and age-associated epigenome dynamics, and few if any investigations have compared human methylome patte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5de8a67d52e6df0b71d2aca212c0365a
https://doi.org/10.1093/nar/gks312
https://doi.org/10.1093/nar/gks312
Publikováno v:
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 59:1234-1243
Common to numerous differentiation pathways in vertebrate organisms is the regulation of key genes through epigenetic mechanisms. Less well studied is to what extent cells of a given differentiation state, but examined at different points within the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e8bad6c102941fc5454c3f53fb56046
https://doi.org/10.1093/gerona/59.12.1234
https://doi.org/10.1093/gerona/59.12.1234
Autor:
Tazuko H. Hirai, Bruce H. Howard, Yoshihiro Nakatani, Jun Qin, Yonghong Wang, Glen Humphrey, Valya R. Russanova
Publikováno v:
Journal of Biological Chemistry. 276:6817-6824
Human histone deacetylases I (HDAC1) and II (HDAC2) are homologous proteins (84% identity) that catalyze release of acetyl groups from modified N-terminal lysines of core histones. Histone deacetylation is correlated with both transient and persisten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5894167c5957c1577f276644db4d9f4
https://doi.org/10.1074/jbc.m007372200
https://doi.org/10.1074/jbc.m007372200
Autor:
Roberto Romero, Valya R. Russanova, Nicholas Sammons, Ji Young Kim, Keiko Ozato, Bruce H. Howard, Tazuko H. Hirai, Pooja Mittal, Paraskevi Salpea, Analía Porrás, Sarah Kozar
Publikováno v:
Molecular immunology. 46(1)
The receptor encoded by the human TLR3 gene recognizes double-strand RNAs (dsRNAs) associated with viral infection. TLR3 expression is strongly activated upon differentiation of monocytes to dendritic cells, and can be further stimulated by the dsRNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e67aa5304cb167ced666c0c774f18c5
https://pubmed.ncbi.nlm.nih.gov/18715647
https://pubmed.ncbi.nlm.nih.gov/18715647
Autor:
Laura F. Newell, David M. Panchision, Yonghong Wang, Bruce H. Howard, Raji Padmanabhan, Tazuko H. Hirai, Glen Humphrey, Ronald D.G. McKay
Publikováno v:
Differentiation; research in biological diversity. 76(4)
In eukaryotic cells, covalent modifications to core histones contribute to the establishment and maintenance of cellular phenotype via regulation of gene expression. Histone acetyltransferases (HATs) cooperate with histone deacetylases (HDACs) to est
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9d936b4747e5c8283f0295718cb7745
https://pubmed.ncbi.nlm.nih.gov/18021260
https://pubmed.ncbi.nlm.nih.gov/18021260
Publikováno v:
The journals of gerontology. Series A, Biological sciences and medical sciences. 59(12)
With completion of the human genome project, patterns of higher order chromatin structure can be easily related to other features of genome organization. A well-studied aspect of chromatin, histone H4 acetylation, is examined here on the basis of its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bafead9614e6d58adf21bd31014b3535
https://pubmed.ncbi.nlm.nih.gov/15699521
https://pubmed.ncbi.nlm.nih.gov/15699521
Autor:
Brett E. Fenster, Nancy S. Bae, Victor J. Ferrans, Kazuyo Takeda, Bruce H. Howard, Zu Xi Yu, Toren Finkel, Tazuko H. Hirai, Hideki Ito, Andrew C. Lee
Publikováno v:
The Journal of biological chemistry. 274(12)
Human diploid fibroblasts eventually lose the capacity to replicate in culture and enter a viable but nonproliferative state of senescence. Recently, it has been demonstrated that retroviral-mediated gene transfer into primary fibroblasts of an activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4174bab05b93bd15b6041ef1d75c9c6a
https://pubmed.ncbi.nlm.nih.gov/10075689
https://pubmed.ncbi.nlm.nih.gov/10075689
Publikováno v:
Scopus-Elsevier
Human diploid fibroblasts (HDF) complete a limited number of cell divisions before entering a growth arrest state that is termed replicative senescence. Two histone deacetylase inhibitors, sodium butyrate and trichostatin A, dramatically reduce the H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::415782c963463c10c566011bfbf4806e
http://www.scopus.com/inward/record.url?eid=2-s2.0-0029778901&partnerID=MN8TOARS
http://www.scopus.com/inward/record.url?eid=2-s2.0-0029778901&partnerID=MN8TOARS
Publikováno v:
Scopus-Elsevier
Mitogenic activities of simian virus 40 large T and small t antigens were studied in serum-deprived human diploid fibroblasts. Wild-type large T and small t cooperated in stimulating DNA synthesis and in inducing hyperphosphorylation of the Rb gene p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c71088068272795d9b843e889f9c30a3
http://www.scopus.com/inward/record.url?eid=2-s2.0-0028245347&partnerID=MN8TOARS
http://www.scopus.com/inward/record.url?eid=2-s2.0-0028245347&partnerID=MN8TOARS