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Rare genetic variation in fibronectin 1 (FN1) protects against APOEε4 in Alzheimer's disease.

Autor: Bhattarai P; Department of Neurology, Columbia University Irving Medical Center, Columbia University New York, New York, NY, USA.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, Columbia University, New York, NY, USA., Gunasekaran TI; Department of Neurology, Columbia University Irving Medical Center, Columbia University New York, New York, NY, USA.; Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA., Belloy ME; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, USA.; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA., Reyes-Dumeyer D; Department of Neurology, Columbia University Irving Medical Center, Columbia University New York, New York, NY, USA.; Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA., Jülich D; Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT, 06520, USA., Tayran H; Department of Neurology, Columbia University Irving Medical Center, Columbia University New York, New York, NY, USA.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, Columbia University, New York, NY, USA., Yilmaz E; Department of Neurology, Columbia University Irving Medical Center, Columbia University New York, New York, NY, USA.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, Columbia University, New York, NY, USA., Flaherty D; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, Columbia University, New York, NY, USA.; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, 10032, USA., Turgutalp B; Department of Neurology, Columbia University Irving Medical Center, Columbia University New York, New York, NY, USA.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, Columbia University, New York, NY, USA., Sukumar G; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, 20817, USA., Alba C; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, 20817, USA., McGrath EM; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, 20817, USA., Hupalo DN; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, 20817, USA., Bacikova D; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, 20817, USA., Le Guen Y; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.; Quantitative Sciences Unit, Department of Medicine, Stanford University, Stanford, CA, USA., Lantigua R; Department of Neurology, Columbia University Irving Medical Center, Columbia University New York, New York, NY, USA.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, Columbia University, New York, NY, USA.; Department of Medicine, College of Physicians and Surgeons, Columbia University New York, New York, USA., Medrano M; School of Medicine, Pontificia Universidad Catolica Madre y Maestra, Santiago, Dominican Republic., Rivera D; Department of Neurology, CEDIMAT, Plaza de la Salud, Santo Domingo, Dominican Republic.; School of Medicine, Universidad Pedro Henriquez Urena (UNPHU), Santo Domingo, Dominican Republic., Recio P; Department of Neurology, CEDIMAT, Plaza de la Salud, Santo Domingo, Dominican Republic., Nuriel T; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, Columbia University, New York, NY, USA.; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, 10032, USA., Ertekin-Taner N; Department of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, 32224, USA.; Department of Neurology, Mayo Clinic Florida, Jacksonville, FL, 32224, USA., Teich AF; Department of Neurology, Columbia University Irving Medical Center, Columbia University New York, New York, NY, USA.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, Columbia University, New York, NY, USA.; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, 10032, USA., Dickson DW; Department of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, 32224, USA., Holley S; Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT, 06520, USA., Greicius M; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA., Dalgard CL; Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, USA.; The American Genome Center, Center for Military Precision Health, Uniformed Services University of the Health Sciences, Bethesda, MD, USA., Zody M; New York Genome Center, New York, NY, 10013, USA., Mayeux R; Department of Neurology, Columbia University Irving Medical Center, Columbia University New York, New York, NY, USA.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, Columbia University, New York, NY, USA.; Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA.; Department of Psychiatry, College of Physicians and Surgeons, Columbia University, 1051 Riverside Drive, New York, NY, 10032, USA.; Department of Epidemiology, Mailman School of Public Health, Columbia University, 722 W 168th St., New York, NY, 10032, USA., Kizil C; Department of Neurology, Columbia University Irving Medical Center, Columbia University New York, New York, NY, USA. ck2893@cumc.columbia.edu.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, Columbia University, New York, NY, USA. ck2893@cumc.columbia.edu.; Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA. ck2893@cumc.columbia.edu., Vardarajan BN; Department of Neurology, Columbia University Irving Medical Center, Columbia University New York, New York, NY, USA. bnv2103@cumc.columbia.edu.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, Columbia University, New York, NY, USA. bnv2103@cumc.columbia.edu.; Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA. bnv2103@cumc.columbia.edu.

Publikováno v: Acta neuropathologica [Acta Neuropathol] 2024 Apr 10; Vol. 147 (1), pp. 70. Date of Electronic Publication: 2024 Apr 10.