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Inhibition of Janus kinase signaling during controlled mechanical ventilation prevents ventilation-induced diaphragm dysfunction.

Autor: Smith IJ; Rigel Pharmaceuticals, South San Francisco, California, USA; and., Godinez GL; Rigel Pharmaceuticals, South San Francisco, California, USA; and., Singh BK; Rigel Pharmaceuticals, South San Francisco, California, USA; and., McCaughey KM; Rigel Pharmaceuticals, South San Francisco, California, USA; and., Alcantara RR; Rigel Pharmaceuticals, South San Francisco, California, USA; and., Gururaja T; Rigel Pharmaceuticals, South San Francisco, California, USA; and., Ho MS; Rigel Pharmaceuticals, South San Francisco, California, USA; and., Nguyen HN; Rigel Pharmaceuticals, South San Francisco, California, USA; and., Friera AM; Rigel Pharmaceuticals, South San Francisco, California, USA; and., White KA; Rigel Pharmaceuticals, South San Francisco, California, USA; and., McLaughlin JR; Rigel Pharmaceuticals, South San Francisco, California, USA; and., Hansen D; Rigel Pharmaceuticals, South San Francisco, California, USA; and., Romero JM; Rigel Pharmaceuticals, South San Francisco, California, USA; and., Baltgalvis KA; Rigel Pharmaceuticals, South San Francisco, California, USA; and., Claypool MD; Rigel Pharmaceuticals, South San Francisco, California, USA; and., Li W; Rigel Pharmaceuticals, South San Francisco, California, USA; and., Lang W; Rigel Pharmaceuticals, South San Francisco, California, USA; and., Yam GC; Rigel Pharmaceuticals, South San Francisco, California, USA; and., Gelman MS; Rigel Pharmaceuticals, South San Francisco, California, USA; and., Ding R; Rigel Pharmaceuticals, South San Francisco, California, USA; and., Yung SL; Rigel Pharmaceuticals, South San Francisco, California, USA; and., Creger DP; Rigel Pharmaceuticals, South San Francisco, California, USA; and., Chen Y; Rigel Pharmaceuticals, South San Francisco, California, USA; and., Singh R; Rigel Pharmaceuticals, South San Francisco, California, USA; and., Smuder AJ; Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, USA., Wiggs MP; Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, USA., Kwon OS; Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, USA., Sollanek KJ; Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, USA., Powers SK; Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, USA., Masuda ES; Rigel Pharmaceuticals, South San Francisco, California, USA; and., Taylor VC; Rigel Pharmaceuticals, South San Francisco, California, USA; and., Payan DG; Rigel Pharmaceuticals, South San Francisco, California, USA; and., Kinoshita T; Rigel Pharmaceuticals, South San Francisco, California, USA; and., Kinsella TM; Rigel Pharmaceuticals, South San Francisco, California, USA; and tkinsella@rigel.com.

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2014 Jul; Vol. 28 (7), pp. 2790-803. Date of Electronic Publication: 2014 Mar 26.