Výsledky vyhledávání - "Taylor Stevens"

Akademický článek

Body‐Wide Inactivation of the Myc‐Like Mlx Transcription Factor Network Accelerates Aging and Increases the Lifetime Cancer Incidence

Autor: Huabo Wang, Taylor Stevens, Jie Lu, Alexander Roberts, Clinton Van't Land, Radhika Muzumdar, Zhenwei Gong, Jerry Vockley, Edward V. Prochownik

Publikováno v: Advanced Science, Vol 11, Iss 34, Pp n/a-n/a (2024)

Abstract The “Mlx” and “Myc” transcription factor networks cross‐communicate and share many common gene targets. Myc's activity depends upon its heterodimerization with Max, whereas the Mlx Network requires that the Max‐like factor Mlx as

Externí odkaz: https://doaj.org/article/21d46c4a8a1c4ee19059c58c19da19c0

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

Premature aging and reduced cancer incidence associated with near-complete body-wide Myc inactivation

Autor: Huabo Wang, Jie Lu, Taylor Stevens, Alexander Roberts, Jordan Mandel, Raghunandan Avula, Bingwei Ma, Yijen Wu, Jinglin Wang, Clinton Van’t Land, Toren Finkel, Jerry E. Vockley, Merlin Airik, Rannar Airik, Radhika Muzumdar, Zhenwei Gong, Michel S. Torbenson, Edward V. Prochownik

Publikováno v: Cell Reports, Vol 42, Iss 8, Pp 112830- (2023)

Summary: MYC proto-oncogene dysregulation alters metabolism, translation, and other functions in ways that support tumor induction and maintenance. Although Myc+/− mice are healthier and longer-lived than control mice, the long-term ramifications o

Externí odkaz: https://doaj.org/article/592f094c57b94e779a6b09c1d1c41fbf

Zobrazit plný text záznamu

Akademický článek

Disruption of Multiple Overlapping Functions Following Stepwise Inactivation of the Extended Myc Network

Autor: Huabo Wang, Taylor Stevens, Jie Lu, Merlin Airik, Rannar Airik, Edward V. Prochownik

Publikováno v: Cells, Vol 11, Iss 24, p 4087 (2022)

Myc, a member of the “Myc Network” of bHLH-ZIP transcription factors, supervises proliferation, metabolism, and translation. It also engages in crosstalk with the related “Mlx Network” to co-regulate overlapping genes and functions. We invest

Externí odkaz: https://doaj.org/article/8f73e5a6de2c4fc8906e9b2509c3f992

Zobrazit plný text záznamu

Plný text ve formátu HTML

Vyhledávací nástroje:

Upřesnit hledání