PRTN3 variant correlates with increased autoantigen levels and relapse risk in PR3-ANCA versus MPO-ANCA disease

Autor: Dhruti P. Chen, Claudia P. Aiello, DeMoris McCoy, Taylor Stamey, Jiajin Yang, Susan L. Hogan, Yichun Hu, Vimal K. Derebail, Eveline Y. Wu, J. Charles Jennette, Ronald J. Falk, Dominic J. Ciavatta

Publikováno v: JCI Insight, Vol 8, Iss 4 (2023)

A GWAS of patients with anti-neutrophil cytoplasmic antibodies (ANCAs) found an association between proteinase-3 ANCA (PR3-ANCA) and a single nucleotide polymorphism (rs62132293) upstream of PRTN3, encoding PR3. The variant (G allele) was shown to be

Externí odkaz: https://doaj.org/article/6edfe8f22c0c4cc28e5dfa690c9af7ec

Demographic, Disease, and Treatment Characteristics of Primary Tracheal Cancers.

Autor: Armel K; Brody School of Medicine (BSOM), East Carolina University (ECU), Greenville, NC, USA., Stamey T; Brody School of Medicine (BSOM), East Carolina University (ECU), Greenville, NC, USA., Maitre J; Brody School of Medicine (BSOM), East Carolina University (ECU), Greenville, NC, USA., Cunningham AR; Brody School of Medicine (BSOM), East Carolina University (ECU), Greenville, NC, USA., Ju AW; Department of Radiation Oncology, BSOM, ECU, Greenville, NC, USA., Burke A; Department of Radiation Oncology, BSOM, ECU, Greenville, NC, USA., Speicher JE; Department of Cardiovascular Sciences, BSOM, ECU, Greenville, NC, USA., Navaid M; Division of Hematology/Oncology, Department of Internal Medicine, BSOM, ECU, Greenville, NC, USA., Bhatt A; Brody School of Medicine (BSOM), East Carolina University (ECU), Greenville, NC, USA., Larkins MC; Brody School of Medicine (BSOM), East Carolina University (ECU), Greenville, NC, USA. larkinsm20@students.ecu.edu.; Department of Emergency Medicine, Boonshoft School of Medicine at Wright State University, Fairborn, OH, USA. larkinsm20@students.ecu.edu.

Publikováno v: Annals of surgical oncology [Ann Surg Oncol] 2024 Nov 18. Date of Electronic Publication: 2024 Nov 18.